Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp104 | Cell biology: osteoblasts and bone formation | ECTS2014

Overexpression of Sp7 in osteoblasts inhibits osteoblast maturation but enhances angiogenesis in bone

Komori Hisato , Miyazaki Toshihiro , Yoshida Carolina A , Komori Toshihisa

Sp7 and Runx2 are essential transcription factors for osteoblast differentiation at an early stage, and Runx2 inhibits osteoblast maturation at a late stage. However, the functions of Sp7 in bone development are not fully elucidated. Thus, we pursued the functions of Sp7 in bone development by generating osteoblast-specific Sp7 transgenic (tg) mice using 2.3 kb Col1a1 promoter. Sp7 tg mice showed osteopenia and woven-bone like structure in the cortic...