Searchable abstracts of presentations at key conferences on calcified tissues

ba0002oc9 | Biology | ICCBH2013

EPO signaling and hematopoietic expansion as causes of osteoporosis in a thalassemia mouse model

Vogiatzi Maria , Yang Zhiwei , Oikonomidou Rea , Rivella Stefano , Boskey Adele , Ross F Paddy

Thalassemia is a chronic anemia associate with high rates of osteoporosis. To determine how erythropoiesis leads to bone loss in thalassemia, we used the th3/+ thalassemia mouse to study the role of erythropoietin (EPO) and hematopoietic progenitors (HP), since they are both increased in thalassemia.Methods: Bone marrow mesenchymal stem cells (MSCs) cultures and MSC cocultures with various HP from wild type (wt) and th3/+ mice were diff...