Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp223 | Cell biology: osteoclasts and bone resorption | ECTS2013

Methylation is not involved in repression of ADRA2A in osteocytes

Mlakar Vid , Zupan Janja , Marc Janja , Mlakar Simona Jurkovic

Osteoporosis is an age related disease characterised by a progressive decrease of bone mineral density and loss of bone quality. Twin studies show that genetic component contributes up to 85% of the BMD variability of population. Surprisingly little variability of BMD can be explained by genetic polymorphisms (~2.9%). This highlights the complex genetic architecture and suggests that many other molecular processes and genes have to be involved. Our previous research showed tha...