Searchable abstracts of presentations at key conferences on calcified tissues

ba0006is11 | (1) (1) | ICCBH2017


van Leeuwen Hans

Abstract not submitted...

ba0006is11biog | (1) (1) | ICCBH2017


van Leeuwen Hans

Biographical DetailsHans van LeeuwenHans (J.P.T.M.) van Leeuwen studied biology in Amsterdam, and did his PhD study on the mechanism of action of PTH in Leiden, The Netherlands. Currently he is professor at the Erasmus University Medical Center in Rotterdam, The Netherlands, leading the research program on Calcium and Bone Metabolism. Main research ...

ba0001pp157 | Cancer and bone: basic, translational and clinical | ECTS2013

Bone metastatic prostate cancer cells regulate their growth via impairing osteoblast differentiation

van Driel Marjolein , Robbesom Iris , Koster Ruben , Boers-Sijmons Bianca , Chiba Hideki , van Leeuwen Hans

Metastases to the bone are the incurable final outcomes of cancer, reducing both length and quality of life in an aggressive way. Despite the discoveries of many factors involved, no cure has been found. Metastatic outgrow starts in interaction with the bone micro-environment. The first attachment in bone is with the osteoblasts lining the endosteal surface. Our aim is to study the role of the osteoblasts in metastatic tumor spread and growth.We used an ...

ba0002p120 | (1) | ICCBH2013

Osteoblasts communicate with their neighbouring cells via extracellular vesicles

Morhayim Jess , Demmers Jeroen , de Jong Ton , Braakman Eric , de Peppel Jeroen van , Cornelissen Jan , van Leeuwen Hans

Objectives: Strong coordination between osteoblasts and bone marrow cells is fundamental for the regulation of healthy bone turnover and other (patho)physiological processes. Extracellular vesicles (EVs) mediate communication between cells via horizontal transfer of proteins and nucleic acids. Osteoblasts secrete EVs in the form of matrix vesicles involved in bone mineralization, however, information about a role in intercellular communication is still lacking. In this study, ...

ba0003pp96 | Cancer and bone: basic, translational and clinical | ECTS2014

Osteoblast-secreted extracellular vesicles stimulate the expansion of CD34+ human umbilical cord blood cells

Morhayim Jess , Demmers Jeroen , van Wijnen Andre , Braakman Eric , Cornelissen Jan , de Peppel Jeroen van , van Leeuwen Hans

Introduction: Umbilical cord blood (UCB) is increasingly used in hematopoietic stem cell (HSC) transplantations; however, the low cell numbers are still remaining as a limiting factor for proper engraftment. Osteoblasts are major constituents of HSC niche and play important roles in regulating HSC self-renewal and differentiation. Recently, extracellular vesicles (EVs) have been implicated in stem cell fate regulation via horizontal transfer of proteins and nucleic acids betwe...