Searchable abstracts of presentations at key conferences on calcified tissues

ba0006is16biog | (1) (1) | ICCBH2017

Body composition and physical activity

Specker Bonny

Biographical DetailsBonny SpeckerDr Bonny Specker is currently Director and Chair of the E.A. Martin Program in Human Nutrition at South Dakota State University. Prior to moving to SDSU in 1997, she was at the University of Cincinnati and Cincinnati ChildrenÂ’s Hospital Medical Center where she received her PhD in Epidemiology and spent 15 years...

ba0005ws3.2 | MicroRNA and bone | ECTS2016

miRNA in diabetic bone disease

Heilmeier Ursula

Epidemiological studies have found that patients with Type 2 Diabetes Mellitus (T2D) have a higher incidence of fragility fractures relative to non-diabetic individuals. Given the substantial morbidity, mortality and costs that emanate from T2D-related fractures, proper recognition of T2D individuals at increased fracture risk is indispensable. Although fracture risk in type 2 diabetics is routinely assessed with WHO-FRAX scores or DXA these methods show limitations. This high...

ba0006is16 | (1) (1) | ICCBH2017

Body composition and physical activity

Specker Bonny

Periods of growth are thought to be the best time to improve bone health through increased loading due to the high rates of bone modeling and remodeling. Although numerous observational studies find higher aBMD and greater bone size in physically active children than sedentary children, this may be a result of confounding and publication bias. Randomized trials are the gold standard in determining causality. A meta-analysis of 22 pediatric exercise trials was conducted using M...

ba0003pp257 | Osteoporosis: pathophysiology and epidemiology | ECTS2014

Molecular evidence of osteoblast dysfunction in elderly men with osteoporotic hip fractures

Foger-Samwald Ursula , Afarin Alaghebandan , Patsch Janina , Schamall Doris , Salem Sylvia , Mousavi Mehdi , Pietschmann Peter

Fractures of the hip are serious complications associated with osteoporosis. In previous work we found evidence of osteoblast dysfunction in middle aged men with idiopathic osteoporosis. The aim of this study was to investigate gene expression and bone microarchitecture in bone samples derived from elderly men with osteoporotic hip fractures. Femoral heads and adjacent bone tissue from 12 men with low-trauma hip fractures (mean age 82±7 years) and consecutive surgical hip...

ba0005p261 | Muscle, physical activity and bone | ECTS2016

Bone and muscle metabolism in lung transplant recipients

Foger-Samwald Ursula , Petrikic Aleksandra , Gruther Wolfgang , Ebenbichler Gerold , Kudlacek Stefan , Pietschmann Peter

Although it is well established, that quality of life improves in patients after lung transplantation (LTx), severe musculoskeletal complications may develop. The aim of this study was to evaluate differences in the muscle markers Myostatin and Follistatin and the bone markers Dickkopf-1 (DKK1), Sclerostin (SOST) and Periostin between LuTx recipients and healthy controls. From 38 LTx patients blood samples were taken when discharged from hospital (LTx1) and 6-9 months after di...

ba0002p107 | (1) | ICCBH2013

Bone cross-sectional geometry and volumetric density at the distal radius in female adolescents with anorexia nervosa

Roggen Inge , Vanbesien Jesse , Gies Inge , Van den Eede Ursula , Lampo Annik , Louis Olivia , De Schepper Jean

Introduction: Osteopenia is a well-known complication of anorexia nervosa (AN) in older adolescents and adults, especially in those with a long duration of the disease and a severe underweight.Aim: We investigated whether young premenarchal girls with AN have similar risk factors for a disturbed bone growth and mineralization.Methods: Twenty-four female premenarchal AN patients as well as 24 age and height matched female controls u...

ba0004p25 | (1) | ICCBH2015

Sitting time has a stronger effect on bone than moderate plus vigorous activity

Binkley Teresa , Weidauer Lee , Specker Bonny

Objective: The use of high-impact weight bearing physical activities has been accepted as a means to increase osteogenic effects on bone. Studies in adolescents found that physical activity could counteract the detrimental effects on bone associated with television time in boys and time spent studying in girls. Our aim was to test the effects of the percent of time spent in moderate plus vigorous activities (ModVig) and sitting (SIT) on bone health. We hypothesized that high M...

ba0005oc5.1 | Risk factors for fracture, Pagets disease of bone and musle and bone | ECTS2016

High serum miRNA 550a-5p levels are risk factors for incident fractures in older postmenopausal women with type 2 diabetes

Heilmeier Ursula , Hackl Matthias , Skalicky Susanna , Weilner Sylvia , Schroeder Fabian , Vierlinger Klemens , Lobach Iryna , Eiriksdottir Gudny , Aspelund Thor , Gudmundsson Elias , Grillari Johannes , Harris Tamara , Link Thomas , Gudnasson Vilmundur , Schwartz Ann

Standard DXA measurements, including FRAX scores, are limited in assessing fracture risk in type 2 diabetes (T2D). Novel, general applicable biomarkers are therefore needed. MicroRNAs (miRNAs) are secreted into the circulation from cells of various tissues proportional to local disease severity. Serum miRNA classifiers including miR-550a-5p were recently found to discriminate T2D women without and with prevalent fragility fractures with high specificity and sensitivity (AUC&#6...

ba0004is11biog | (1) (1) | ICCBH2015

Recent advances in limb lengthening and deformity correction

Herzenberg John

Biographical DetailsDr John Herzenberg graduated from Boston University Medical School and trained at Duke University for Orthopaedics and Toronto Sick Kids for Pediatric Orthopaedics. He specializes in the diagnosis and treatment of adult and pediatric patients with congenital abnormalities, joint contractures, neuromuscular disorders, non-unions, malunions, deformity, and bone defects. ...