Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp91 | Bone development/growth and fracture repair | ECTS2013

Pediatric differences in bone mineral density according to ethnic background in children: the Generation R Study

Medina-Gomez Carolina , Heppe Denise H M , Hofman Albert , Jaddoe Vincent , Uitterlinden Andre , Rivadeneira Fernando

Aim: Differences in fracture risk between ethnic groups have been documented. The basis for these differences is yet incomplete and the age at what ethnic differences appear is uncertain. Assessment of bone health in pediatric populations could bring insights on factors compromising bone accrual. We describe here differences in total body bone mineral density (TB-BMD) in a unique setting of children of the same age, measured with the same device (iDXA) different ethnic backgro...

ba0004p171 | (1) | ICCBH2015

Bone-muscle unit assessment with pQCT in children with inflammatory bowel disease following treatment with Infliximab

Altowati Mabrouka , Malik S , Shepherd S , P McGrogan , RK Russell , SF Ahmed , SC Wong

Objective: To evaluate bone and muscle mass in children with inflammatory bowel disease (IBD) following infliximab (IFX) therapy.Methods: Prospective longitudinal study of 19 children (12 males), 17 crohn’s disease (CD), 1 ulcerative colitis (UC), 1 IBD unclassified (IBDU) of bone evaluation commencing treatment with IFX. Bone and muscle parameters were measured by pQCT at the non-dominant distal radius at 4 and 66% at baseline and 6 months. pQCT pa...

ba0004is20biog | (1) (1) | ICCBH2015

Bone morbidity in children with leukemia

Ward Leanne M

Biographical DetailsDr Leanne M Ward is an Associate Professor of Pediatrics at the University of Ottawa where she holds a Research Chair in Pediatric Bone Health. She is the Medical Director of the Pediatric Bone Health Clinical and Research Programs at the Children’s Hospital of Eastern Ontario (CHEO) and a pediatric endocrinologist within the Division of Endocrinology and Metaboli...

ba0002p172 | (1) | ICCBH2013

Longitudinal assessment of spinal bone mineral density in children with neurofibromatosis type 1 using dual energy absorptiometry and quantitative computed tomography

Eelloo Judith , Ward Kate , Huson Susan M , Adams Judith E , Russell Sarah , Wright Naville , Evans Gareth , Mughal M Zulf

Aim: Scoliosis is a common skeletal problem affecting 10–30% of patients with neurofibromatosis type 1 (NF1). NF1 patients have been shown to have reduced bone mineral density (BMD) which may play a role in the pathogenesis or progression of scoliosis. Our centre is one of four international centres currently evaluating the efficacy of various spinal imaging techniques and BMD as predictors for scoliosis in NF1. In our cohort we measured the lumbar spine (LS) BMD both by ...

ba0001pp67 | Bone development/growth and fracture repair | ECTS2013

Hip fracture induces a transient appearance of circulating mesenchymal stem cells

Heino Terhi J , Sederquist Bettina , Aro Hannu T

We have previously demonstrated the presence of circulating mesenchymal stem cells (MSCs) in fracture patients. However, the exact time for their appearance in circulation remains unknown. Nine patients (five females, four males, age 70±12 years, range 55–89 years) with a fresh femoral neck fracture were recruited in the study, which was approved by the local ethical committee. Bone marrow (BM) sample drawn from the iliac crest of all patients served as the individua...

ba0004is24biog | (1) (1) | ICCBH2015

The new histology

Misof Barbara M

Biographical DetailsBarbara M Misof is Staff Scientist at the Ludwig Boltzmann Institute of Osteology, Vienna, Austria. She completed her PhD in Physics and Postgraduate Education in Medical Physics at the University of Vienna in 2000. In 2002, she received the Herbert-Czitober-Research Award of the Austrian Society of Bone and Mineral Research. Her areas of interest are bone material pro...

ba0006p141 | (1) | ICCBH2017

Unique correlation pattern between cortical trabecular bone qualities and standard dynamometer handgrip strength in girls with adolescent idiopathic scoliosis (AIS)?

Tam Elisa M S , Cheuk Ka-Yee , Hung Vivian W Y , Yu Fiona W P , Ng Bobby K W , Guo X Edward , Cheng Jack C Y , Lam Tsz-Ping

Objective: Grip strength is a marker of muscle mass which can optimize bone strength during puberty. While previous studies have shown AIS girls had poor bone qualities and mechanical properties when compared with non-AIS girls, the correlation between bone qualities and handgrip strength in AIS remains undefined. This study aimed to investigate the correlation between handgrip strength and bone qualities including volumetric bone mineral density (vBMD), bone geometry, trabecu...

ba0004p141 | (1) | ICCBH2015

Persistence of musculoskeletal abnormalities in children and adolescents with inflammatory bowel disease: a prospective longitudinal study

S McCarrison , Mason A , SC Wong , Shepherd S , P McGrogan , Russell R , SF Ahmed

Objectives: To evaluate musculoskeletal development using pQCT and DXA in childhood onset inflammatory bowel disease (IBD).Methods: Prospective longitudinal study with 12 months follow-up in 43 children (23 males) with IBD: 30 crohn’s disease(CD), 13 ulcerative colitis (UC) and inflammatory bowel disease unclassified (IBDU). pQCT at 4% and 66% radius, DXA for total body (TB), lumbar spine (LS) bone mineral content were assessed at baseline and 12 mo...

ba0004p59 | (1) | ICCBH2015

Vibration treatment can enhance the bioactive response of osteoblasts to vitamin D in adolescent idiopathic scoliosis patients

Zhang Jiajun , Lee WayneY W , Shi Benlong , Tam Elisa M S , Chen Huanxiong , Lee Simon K M , Ng Bobby K W , Cheng Jack C Y , Lam Tsz Ping

Objectives: Adolescent idiopathic scoliosis (AIS) is a complex three-dimensional spinal deformity associated with low bone mass. Our previous clinical trial demonstrated the anabolic bone effect of vibration treatment (VT) at the femoral neck in AIS subjects. The therapeutic effect was more pronounced in those with optimal serum 25(OH) Vit-D level (>40 nmol/l). To investigate possible factor interaction between Vit-D and VT on their anabolic bone effects, this in-vitro...

ba0004p187 | (1) | ICCBH2015

TBS increases over time in pre-teen girls

Libber J , Winzenrieth R , Krueger D , Scarpella T , Binkley N

Muscle and loading force application alters bone structure and increases bone mineral density (BMD), particularly during growth. However, bone microarchitectural texture, as assessed by the trabecular bone score (TBS), changes during growth is unknown. We hypothesized that TBS would be positively correlated with growth and higher in growing girls participating in regular physical exercise.68 girls (mean age 12±0.3 years; BMI 18±2.8 kg/m2</...