Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p464 | Other diseases of bone and mineral metabolism | ECTS2016

The course and management of craniofacial fibrous dysplasia: a case series

Majoor Bas , Appelman-Dijkstra Natasha , Bruggemann Jens , van de Sande Michiel , Dijkstra Sander , Hamdy Neveen

Introduction: Cranialfacial fibrous dysplasia (CFD) presents with pain, facial asymmetry and/or neurological complications. It has been suggested that patients with CFD respond favourably to treatment with bisphosphonates, by a decrease in pain and arrest of progression. Therefore, we performed a retrospective study of 56 patients with CFD in our center.Methods: We assessed clinical characteristics and disease course. Furthermore, clinical and biochemica...

ba0006p171 | (1) | ICCBH2017

Review of lower limb range of movement following intramedullary fixation in children with Osteogensis Imperfecta

Marr Caroline

Osteogenesis Imperfecta (OI) is a genetic condition which alters collagen biosynthesis(1). Prevalence is estimated at 1 in every 15, 000 births. It is a disorder with a wide spectrum of severity, with cases ranging from the extremely mild to those of perinatal mortality. Typical features include bone fragility; short stature; long bone deformity and persistent blue sclera(2). Although currently there is no cure for OI, with the input of a multidisciplinar...

ba0007p166 | (1) | ICCBH2019

The ketogenic diet and bone density: a retrospective longitudinal cohort study

Draaisma Jos , Hampsink Brieke , Willemsen Michel , Linders Miel , van Houdt Nicole

Background: The Ketogenic Diet Treatment (KDT) is a well-established intervention for intractable childhood epilepsy and the first choice treatment for Gluccose-1-transporter-deficiency-syndrome and Pyruvate-dehydrogenase-complex deficiency. During long-term follow up of children treated with KDT an increased incidence of bone fractures has been found. However, the exact contribution of KDT to a decreased BMD remains unclear. Prophylactic supplementation with calcium and vitam...

ba0002p54 | (1) | ICCBH2013

Association of calcium and dairy intake with growth in Indian children

Ekbote Veena , Khadilkar Anuradha , Chiplonkar Shashi , Mughal M Zulf , Khadilkar Vaman

Objective: Optimal intakes of calcium and milk are necessary in children and adolescents to facilitate not only mineralization but also growth in stature. Low intakes of calcium and also, of milk and milk products in Indian children have been reported. Hence, the objective was to study Indian children’s growth with respect to their calcium and dairy intakes.Methods: We studied 220 children (boys 104, age range 2–16 years). Data on their height,...

ba0002p107 | (1) | ICCBH2013

Bone cross-sectional geometry and volumetric density at the distal radius in female adolescents with anorexia nervosa

Roggen Inge , Vanbesien Jesse , Gies Inge , Van den Eede Ursula , Lampo Annik , Louis Olivia , De Schepper Jean

Introduction: Osteopenia is a well-known complication of anorexia nervosa (AN) in older adolescents and adults, especially in those with a long duration of the disease and a severe underweight.Aim: We investigated whether young premenarchal girls with AN have similar risk factors for a disturbed bone growth and mineralization.Methods: Twenty-four female premenarchal AN patients as well as 24 age and height matched female controls u...

ba0003cc4 | (1) | ECTS2014

Two novel compound heterozygous mutations in LRP5 cause osteoporosis pseudoglioma syndrome

Alonso N , Soares D C , Kabir D , Summers G D , Ralston S H , Gregson C L

Osteoporosis pseudoglioma syndrome (OPPGS) is a rare autosomal recessive disorder characterised by congenital or juvenile-onset blindness, severe juvenile-onset osteoporosis, and skeletal fragility. OPPGS is caused by loss-of-function mutations in the LRP5 gene, a member of the LDL receptor family. It activates the canonical Wnt/β-catenin pathway, regulating osteoblastic bone formation. We investigated a 40-year-old Caucasian male presenting with congenital blind...

ba0003oc2.1 | Osteoporosis epidemiology | ECTS2014

Low serum thyrotropin level and duration of suppression as a predictor of major osteoporotic fractures – the openthyro register cohort

Abrahamsen Bo , Jorgensen Henrik L , Laulund Anne S , Nybo Mads , Brix Thomas H , Hegedus Laszlo

Objective: To assess the relationship between thyrotoxicosis and osteoporotic fractures in men and women.Design: Register-based cohort study in patients with a TSH measurement in the region of Funen 1996–2010. All determinations were done in the same lab serving all hospitals and GP practices. Persons with raised TSH or a history of thyroid/pituitary disease were not included.Results: The study population consisted of 222 138 ...