Searchable abstracts of presentations at key conferences on calcified tissues

ba0004p31 | (1) | ICCBH2015

Mineral metabolism in children with autosomal dominant polycystic kidney disease

De Rechter Stephanie , Bacchetta Justine , Dubourg Laurence , Cochat Pierre , Van Dyck Mieke , Evenepoel Pieter , Levtchenko Elena , Mekahli Djalila

Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic cause of renal failure. Data from adult ADPKD population show increased fibroblast growth factor 23 (FGF23) levels while circulating Klotho levels decrease, with a low TmP/GFR even in patients with normal renal function. Moreover, in ADPKD animal models, cyst lining renal cells were demonstrated to produce FGF23, although the animals displayed FGF23 resistance. No data are available in a paediatr...

ba0005p431 | Other diseases of bone and mineral metabolism | ECTS2016

Bisphosphonate therapy in Langerhans cell histiocytosis: an international retrospective descriptive study

Chellapandian Deepak , Makras Polyzois , Kaltsas Gregory , van den Bos Cor , Carret Anne-Sophie , Weitzman Sheila , Egeler Maarten , Abla Oussama

Introduction: Langerhans cell histiocytosis (LCH) is a monoclonal disorder characterized by proliferation and accumulation of atypical Langerhans cells. Bone involvement is particularly destructive and to date, no standard of care exists. Bisphosphonates are osteoclast inhibitors that could target the multinucleated giant cells within the LCH lesions and might be used to alleviate bone pain and the progression of disease.Objective: To evaluate the effica...

ba0004oc15 | (1) | ICCBH2015

Osseous side effects on the growing skeleton exerted by tyrosine kinase inhibitor treatment: data observed in pediatric patients with chronic myeloid leukemia in comparison to a juvenile rat model

Tauer Josephine T , Hofbauer Lorenz C , Erben Reinhold G , Suttorp Meinolf

Background: The tyrosine kinase inhibitor (TKI) imatinib is applied as front-line treatment in adult and pediatric patients with chronic myeloid leukemia (CML) in order to selectively inhibit the causative oncogenic BCR-ABL1 tyrosine kinase. However, TKIs exhibit off-target effects on further kinases involved in the regulation of bone metabolism. As consequence, pediatric patients display longitudinal growth retardation while on imatinib treatment. As CML is a rare disease in ...

ba0003ht5 | (1) | ECTS2014

Skin inflammation causes bone loss with reduced bone formation through systemic IL-17A release

Uluckan Ozge , Keller Johannes , Karbach Susanne , Croxford Andrew , Finzel Stephanie , Koenders Marije , Berg Wim Van Den , Amling Michael , Waisman Ari , Schett Georg , Wagner Erwin

Patients with chronic inflammatory diseases such as psoriasis are at high risk for developing osteoporosis. Psoriatic arthritis patients exhibit bone loss caused by increased bone resorption through activation of osteoclasts. However, it is not clear whether psoriasis can lead to bone loss in the absence of arthritis. Using mouse models with skin inflammation as well as psoriasis patient samples, we show that increased circulating IL-17A from the inflamed skin triggers bone lo...

ba0006p104 | (1) | ICCBH2017

Dietary calcium deficiency contributes to the causation of nutritional rickets (NR) in the United Kingdom (UK): data from the British Paediatric Surveillance Unit (BPSU) NR survey

Zulf Mughal M. , Calder Alistair , Blair Mitch , Julies Priscilla , Pall Karina , Lynn Richard , McDonnell Ciara , McDevitt Helen , Shaw Nick J.

Background: Rickets is a disorder of the growing child arising from impaired mineralisation of the growth plate and osteoid. The most common cause of NR in the UK is thought to be secondary to vitamin D deficiency [VDD; serum 25-hydroxyvitamin D (25OHD) <25 nmol/l], although in some African & South Asian countries dietary calcium deficiency (DCaD) by itself, or together with VDD is an important cause of NR (Ann Trop Paediatr. 2006;26:1–16). Currently, the data on ...

ba0003pp255 | Osteoporosis: evaluation and imaging | ECTS2014

Dynamic changes in bone marrow adiposity during the menstrual cycle

Veldhuis-Vlug Annegreet , Limonard Eelkje , van Dussen Laura , Runge Jurgen , Tanck Michael , Endert Erik , Heijboer Annemieke , Fliers Eric , Hollak Carla , Akkerman Erik , Bisschop Peter

Background: Bone marrow (BM) adiposity is inversely related to bone mineral density and increases with ageing and menopause. We previously observed that the variation in BM fat fraction was more pronounced in premenopausal women compared to men and postmenopausal women. We hypothesized that the variation in BM fat fraction in premenopausal women is associated with hormonal variations during the menstrual cycle.Objective: To investigate the dynamic change...

ba0001pp383 | Osteoporosis: pathophysiology and epidemiology | ECTS2013

Detection of autoantibodies to osteoprotegerin in patients with rheumatoid arthritis and their association with disease activity

Hauser Barbara , Riches Philip , Gilchrist Tamara , Wilson Jim F , Fraser William D , Ralston Stuart H

Introduction: Osteoporosis and fragility fractures are recognized complications of rheumatoid arthritis (RA). Previously Riches et al. described a patient with celiac disease and severe osteoporosis in whom neutralizing antibodies to osteoprotegerin (OPG) were present. The aim of this study was to determine if OPG autoantibodies were present in patients with RA and other rheumatic diseases and to relate these to clinical features.Methods: We dev...

ba0002p47 | (1) | ICCBH2013

Vitamin D deficiency and structural and functional state of bone tissue in schoolchildren of Ukraine

Povoroznyuk Vladyslav , Tyazhka O , Balatska Nataliya , Budnik T , Kubey I , Haliyash N

Introduction: Vitamin D is an essential material in bone metabolism, and regulation of body minerals. Vitamin D deficiency has various causes, including limitations in sunlight exposure (type of clothing, sunscreen usage, indoor activity), seasonal geographic latitude and altitude, atmospheric pollution, diet, and ageing.The aim of the work was to determine the frequency of vitamin D deficiency among Ukrainian schoolchildren and its influence on bone min...

ba0003pp356 | Osteoporosis: treatment | ECTS2014

Changes in lumbar spine QCT, DXA and TBS with denosumab, alendronate or placebo in postmenopausal women with low bone mass

Thomas Thierry , Cheung Angela M , Shane Elizabeth , Zanchetta Jose R , Kearns Ann , Hans Didier , Lin Celia J F , Austin Matthew , Libanati Cesar

Patients with osteoporosis require treatment with therapies that reduce the risk of fracture which at the spine is significantly influenced by bone microarchitecture. Quantitative computed tomography (QCT) and dual X-ray absorptiometry (DXA) allow measurement of bone mineral density (BMD), a known indicator of fracture risk. Trabecular bone score (TBS) is a novel gray-level measurement derived from spine DXA image texture that is related to microarchitecture and associates wit...

ba0005p241 | Genetics and Epigenetics | ECTS2016

Identification of a novel locus on 2q13 of large effect size which predisposes to clinical vertebral fractures independently of BMD: the GEFOS consortium

Alonso Nerea , The Clinical Vertebral Fracture Consortium Nerea , Uitterlinden Andre , Rivadeneira Fernando , Ralston Stuart H

Vertebral fractures are the most common complication of osteoporosis, but little is known about the genetic determinants of susceptibility. Here we present the results of a genome wide association study in 1553 postmenopausal women with clinical vertebral fractures and 4340 controls, with replication in 667 cases and 2105 controls. A locus tagged by a less frequent variant (rs10190845, A-allele MAF=0.05) was identified on chromosome 2q13 as a strong predictor of clinical verte...