Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp231 | Osteoporosis: evaluation and imaging | ECTS2014

The impact of physical activity on estimated bone stiffness as assessed by multisite quantitative ultrasound: the Canadian Multicentre Osteoporosis study

Brown Jacques , Adachi Jonathan , Hanley David , Davison Kenneth , Olszynski Wojciech

This investigation sought to assess the relationship between physical activity (PA) and estimated bone stiffness as assessed by multisite quantitative ultrasound (mQUS) in a large cohort. A total of 1177 men and 2949 women were assessed with mQUS (Beam-Med Omnisense quantitative ultrasound; Isreal) at the distal radius, tibia, and phalanx sites as part of the Canadian Multicentre Osteoporosis Study (clinical sites included Saskatoon, Calgary, Hamilton, Quebec City, Halifax and...

ba0004p84 | (1) | ICCBH2015

Different causes of infantile hypercalcemia

Kutilek Stepan , Plasilova Ivana , Gut Josef , Konrad Martin , Schlingman Karl P , Machata-Hanulikova Kristyna , Teterova-Cerna Hana

Background: Hypercalcemia in childhood is rare, can be of various origin and might go unrecognized until severe signs appear. We demonstrate hypercalcemia of different causes in two infants.Case no 1.: 5-month old girl with failure to thrive, constipation, muscle hypotonia, dehydration, where total calcaemia peaked to 4.25 mmol/l. Low calcium diet, application of glucocorticoids and furosemide resulted in a drop in calcaemia to values below 3 mmol/l and ...

ba0002p143 | (1) | ICCBH2013

Fractures in juvenile idiopathic arthritis children: role of disease activity and genetic factors

Mikhail Mikhail , Demin Grigoriy , Smirnov Arseniy , Klyushina Alexandra , Scheplyagina Larisa , Larionova Valentina

Objectives: We evaluated role of disease activity and genetic factors in fractures predisposing among juvenile idiopathic arthritis (JIA) children.Methods: Bone mineralization parameters were detected by dual-energy X-ray absorptiometry of lumbar spine L1–L4 in 197 (81 boys and 116 girls) JIA children. Bone biochemical markers included osteocalcin, C-terminal telopeptides, parathyroid hormone (PTH), Ca, Ca++, P, tota...

ba0001pp435 | Osteoporosis: treatment | ECTS2013

Denosumab's dynamic CTX profile is maintained over 6 years of treatment: first 3 years of the FREEDOM extension study

Roux C , McClung MR , Franchimont N , Adami S , Ebeling PR , Reid IR , Resch H , Weryha G , Daizadeh N , Wang A , Wagman RB , Eastell R

Denosumab (DMAb) has a unique profile of bone resorption inhibition: CTX decreases rapidly by 3 days and inhibition is released at the end of the 6-month dosing interval, when DMAb serum levels decrease (McClung NEJM 2006). The dynamic CTX inhibition profile is not curtailed by continued treatment. In the 3-year FREEDOM study, CTX values at 6 months were influenced by baseline CTX values and days since the 1st injection (Eastell JBMR 2011). With 3 additional ...

ba0007p177 | (1) | ICCBH2019

Feasibility of a 13-week targeted exercise intervention on tibial bone mineral density in adolescents with Developmental Coordination Disorder

Tan Jocelyn , Siafarikas Aris , Hands Beth , McIntyre Fleur , Hart Nicolas , Rantalainen Timo , Chivers Paola

Objectives: Adolescents with Developmental Coordination Disorder (DCD) have significantly lower bone mineral density (BMD) compared to their non-affected peers. Their difficulty in performing weight bearing movement skills is hypothesised to explain poorer bone characteristics. This feasibility study examined the impact of a 13-week exercise intervention on tibial bone parameters in adolescents with DCD.Methods: Twenty-eight adolescents with DCD particip...

ba0005p458 | Other diseases of bone and mineral metabolism | ECTS2016

Colony-stimulating factor 1 receptor a (Csf1ra)-deficient zebrafish as a model of unbalanced bone remodeling

Caetano-Lopes Joana , Urso Katia , Henke Katrin , Aliprantis Antonios O , Charles Julia F , Warman Matthew L , Harris Matthew P

Osteoclasts are multinucleated giant cells derived from the monocyte/macrophage lineage in the presence of receptor activator of nuclear factor kappa-B ligand (RANKL) and colony-stimulating factor 1 (CSF1). The bone remodeling process in zebrafish is incompletely understood. Here we describe several methods to quantify bone formation and resorption using a zebrafish mutant that lacks functional colony stimulating factor 1a receptor (csf1ramh5/mh5). Mice deficient in...

ba0005p77 | Bone development/growth and fracture repair | ECTS2016

The high bone volume phenotype of female nNOS KO mice is not maintained with ageing

van't Hof Rob , Rose Lorraine , Charlesworth Gemma , Prior Amanda , Daroszewska Anna

We have previously shown that female neuronal nitric oxide synthase knockout (nNOS KO) mice have increased trabecular bone volume. However, this study was performed in mice at 10 weeks of age only. To investigate whether the high bone volume is maintained during ageing, we compared 3-month- and 12-month-old wild type (WT) and nNOS KO mice using μCT. The tibias from 8 WT and 8 nNOS KO mice at each age were dissected, fixed for 24 h in buffered formalin, stored in 70% ethan...

ba0002p39 | (1) | ICCBH2013

Prevalence of vitamin D deficiency in adolescent Muslim girls attending a school in the UK, which adheres to a conservative dress code

Lukman S , Syahanee R , Berry J L , Mughal M Z

Aim: To determine the prevalence of vitamin D deficiency among adolescent Muslim girls attending a school in the UK, which adheres to a conservative dress code.Methods: Fifty-six (31%) out of 180 girls attending a Muslim High School for Girls (median age 13.2years, (IQR 12.5–13.8 years)) took part in this cross-sectional study. Seventy-nine percent (n=45) were of South Asian origin, 3.5% were Black African origin (n=2), 1.8% was Mi...

ba0003pp26 | Bone biomechanics and quality | ECTS2014

Structural analysis of tooth and jawbone in a type 2 diabetes mouse model

Pabisch Silvia , Yamaguchi Tsuguno , Koike Yasushi , Egashira Kenji , Kataoka Shinsuke , Wagermaier Wolfgang , Weinkamer Richard , Murakoshi Michiaki , Fratzl Peter

In type 2 diabetes mellitus (T2DM) patients, an increased fracture risk is observed, although the bone mineral density is even higher than in non-diabetic patients, which raises the question of the quality of the organic and inorganic matrix in bone1,2. T2DM is also known to favor inflammation of the gingiva and paradontosis in general. However, little is known about the mineral nano-architecture in the mandible and about the possible influence of diabetes. Using sy...

ba0001pp283 | Genetics | ECTS2013

Discovery and replication of several loci significantly associated with lean body mass: a large meta-analysis of genome wide association studies (GWAS) from the ‘charge’ and ‘gefos’ consortia

Kiel Douglas P , Yerges-Armstrong Laura M , Hsu Yi-Hsiang , Stolk Lisette , Karasik David , Loos Ruth J F , Gudnason Vilmundar , Smith Albert , O'Connell Jeffrey R , Fu Amish , Fu Mao , Streeten Elizabeth A , Cauley Jane A , Robbins John A , Psaty Bruce , Johnson Toby , Kutalik Zoltan , Mitchell Braxton D , Livshits Gregory , Harris Tamara B , Ohlsson Claes , Zillikens M Carola

Introduction: The creatine kinase (CK) is a dimeric enzyme, involved in energetical metabolism. It is present in many tissues, but higher concentration in skeletal and cardiac muscle.Therefore, conditions that involve muscle tissue may increase this serum enzyme. Such enzyme elevation is usually observed in inflammatory myopathies and others autoimmune diseases.Sometimes some elevation in CK is not fully understood out off these co...