Searchable abstracts of presentations at key conferences on calcified tissues

ba0005oc3.2 | Clinical trials, FGF-23 and focal osteoporosis | ECTS2016

Effects of Denosumab (Dmab) on bone matrix mineralization: results from the phase 3 FREEDOM trial

Dempster David W , Brown Jacques P , Yue Susan , Farlay Delphine , Rizzo Sebastien , Song Jenny , Wang Andrea , Wagman Rachel B , Boivin Georges

Low fracture (FX) incidence has been demonstrated in women with postmenopausal osteoporosis (PMO) treated with DMAb for up to 10 years in the FREEDOM extension [Bone ASBMR 2015]. Bone biopsy-based assessment of DMAb’s effects at the tissue level has demonstrated a low remodelling rate consistent with DMAb’s mechanism of action (Reid JBMR 2010; Brown JBMR 2014). From FREEDOM, we report the effects of DMAb on bone matrix mineralization in women who un...

ba0005p240 | Genetics and Epigenetics | ECTS2016

Analysis of the polyalanine repeat polymorphism in the RUNX2 gene in relation to bone mineral density and fracture risk in Maltese postmenopausal women

Formosa Melissa M , Sladden Andre J , Scerri Daniel , Xuereb-Anastasi Angela

Introduction: Runt-related transcription factor 2 (RUNX2) is a major transcription factor essential for the regulation of osteoblast and chondrocyte differentiation, hence affecting skeletogenesis, bone and cartilage formation. The RUNX2 protein has unique consecutive polyglutamine and polyalanine repeats (Q/A) which are important for its transactivation function. Several variants within the RUNX2 gene have been implicated in osteoporosis and fracture susceptibility.<...

ba0007p105 | (1) | ICCBH2019

Respiratory health impacts quality of life for adults with OI

Yonko Elizabeth , Carter Erin , Sandhaus Robert , Raggio Cathleen

Objectives: Respiratory insufficiency is the leading cause of mortality for individuals diagnosed with Osteogenesis Imperfecta (OI), a skeletal dysplasia clinically characterized by fractures, bone fragility, and scoliosis. The objective of this study is to explore respiratory function and its relation to quality of life, type of OI, presence of scoliosis, stature, and other factors such as age or co-existing co-morbidities.Methods: Adults with OI comple...

ba0003pp162 | Cell biology: osteoclasts and bone resorption | ECTS2014

The role of IL-6 as a modulator of osteoclastic resorption in vitro in acute Charcot osteoarthropathy

Petrova Nina , Petrov Peter , Edmonds Michael , Shanahan Catherine

Aims: To investigate the role of interleukin-6 (IL-6) as a modulator of osteoclastic resorption in vitro in acute Charcot osteoarthropathy.Material and methods: Peripheral blood mononuclear cells were isolated from six patients with acute Charcot osteoarthropathy, five diabetic and five healthy controls and cultured in vitro on bovine bone disks for 21 days in the presence of i) macrophage-colony stimulating factor (M-CSF) and receptor ...

ba0003pp243 | Osteoporosis: evaluation and imaging | ECTS2014

Trabecular bone score, bone mineral density and body composistion in men of different ages

Povoroznyuk Vladyslav , Musiienko Anna , Povoroznyuk Roksolana , Dzerovych Nataliia , Hans Didier

The aim of this study was to evaluate the trabecular bone score (TBS), bone mineral density (BMD) and body composition in men of various ages.Materials and methods: 300 men aged 40–87 years (mean age – 60.5±0.6 years; mean height – 1.61±0.003 m; mean weight – 84.1±0.9 kg) were examined. The patients were divided into the following age-dependent groups: 40–49 years (n=52), 50–59 years (n=90), ...

ba0001pp52 | Bone biomechanics and quality | ECTS2013

Bone morphometry from human peripheral quantitative computer tomography scans is preserved by virtual high-resolution image reconstruction

Schulte Friederike , Badilatti Sandro , Parkinson Ian , Goldhahn Jorg , Muller Ralph

Peripheral quantitative computed tomography (pQCT) is receiving considerable attention in the diagnosis and monitoring of human bone diseases. It is well accepted that lower image resolution compared to micro-computed tomography (micro-CT) affects bone morphometry. With advances in micro-CT evaluation techniques such as sample-specific remodeling simulations or dynamic bone morphometry, there is the potential to also allow the application of such techniques to clinical pQCT sc...

ba0001pp294 | Muscle, physical activity and bone | ECTS2013

Influence of mechanical loading and skeleton geometry in bone mass at the proximal femur in 10–12 years old children: a longitudinal study

Cardadeiro Graca , Baptista Fatima , Rosati Nicolleta , Zymbal Vera , Rebocho Lurdes , Bruno Paula M , Janz Kathleen F , Sardinha Luis B

Using a longitudinal observational study with two evaluations and a 1 year follow-up interval, we investigated the influence of everyday physical activity (PA) and skeletal geometry in bone mineral density (BMD) and bone mass distribution at the proximal femur (PF) in 96 girls and 81 boys (10–12 years). Whole body and left hip DXA scans were used to derive geometric measures of the pelvis (inter acetabular distance – IAD) and PF (abductor lever arm – ALA). BMD w...

ba0006p013 | (1) | ICCBH2017

Longitudinal evaluation of bone mass, geometry and metabolism in adolescent male athletes. The PRO-BONE study

Swolin-Eide Diana , Hansson Sverker , Magnusson Per , Ronne Maria , Heideman Malene , Schou Anders , Laursen Jens Ole , Wedderkopp Niels , Husby Steffen , Molgaard Christian , Ubago-Guisado Esther , Vlachopoulos Dimitris , de Moraes Augusto Cesar , Torres-Costoso Ana , Wilkinson Kelly , Metcalf Brad , Sanchez-Sanchez Javier , Gallardo Leonor , Gracia-Marco Luis Tseretopoulou Xanthippi , Amin Nadia , Mushtaq Talat , Chaplais Elodie , Naughton Geraldine , Greene David , Duclos Martine , Masurier Julie , Dutheil Frederic , Thivel David , Courteix Daniel , Ubago-Guisado Esther , Vlachopoulos Dimitris , de Moraes Augusto Cesar , Torres-Costoso Ana , Wilkinson Kelly , Metcalf Brad , Sanchez-Sanchez Javier , Gallardo Leonor , Gracia-Marco Luis Cheuk Ka-Yee , Wang Xiaofang , Yu Fiona W P , Tam Elisa M S , Ng Bobby K W , Ghasem-Zadeh Ali , Zebaze Roger , Seeman Ego , Cheng Jack C Y , Lam Tsz-Ping , Kutilek Stepan , Formanova Daniela , Senkerik Marian , Skalova Sylva , Markova Daniela , Langer Jan , Kutilek Stepan , Vracovska Martina , Pikner Richard , Fejfarkova Zlatka , Gracia-Marco Luis Vlachopoulos Dimitris , Ubago-Guisado Esther , Barker Alan R , Fatouros Ioannis G , Avlotini Alexandra , Knapp Karen K , Moreno Luis A , Williams Craig A , Vlachopoulos Dimitris , Barker Alan R , Williams Craig A , Ubago-Guisado Esther , Ortega Francisco B , Ruiz Jonathan R , Moreno Luis A , Fatouros Ioannis G , Avloniti Alexandra , Gracia-Marco Luis

Objectives: Cross-sectional studies show that exercise may have positive effects on bone outcomes in youth. However, there is no evidence from longitudinal studies, which type of sports can induce improvements in bone acquisition in adolescent athletes. Therefore, this study aimed to investigate the longitudinal differences in bone acquisition and bone metabolism between adolescent males participating in osteogenic (football) and non-osteogenic (swimming, cycling) sports compa...

ba0002p81 | (1) | ICCBH2013

Reference point indentation testing detects age-related changes in tissue mechanical properties in mice

Forbes Mhairi , Bishop Nick , Grabowski Peter

Objectives: The ability to discriminate bone fractures that result from non-accidental injuries and those that result from underlying bone fragility is limited by the lack of clinical instrumentation to directly measure bone mechanical properties. The BioDent Hfc (Active Life Scientific) is an experimental device that has been validated for measuring cortical bone fracture resistance in adults. We are currently developing protocols to test the feasibility of its use in infants...

ba0002op1 | (1) | ICCBH2013

Skeletal effects of hypothyroidism are mediated by thyroid hormone receptor α

Cheung Moira , Boyde Alan , Evans Holly , Bassett Duncan , Williams Graham

Childhood hypothyroidism results in delayed skeletal maturation and impaired growth. Thyroid hormones act via temporo-spatially regulated thyroid hormone receptors α (TRα) and (TRβ).In the skeleton, TRα is the predominant receptor and we hypothesise that the skeletal effects of hypothyroidism are mediated by TRα.To investigate this we assessed the response of wild-type (WT), TRα knockout (TRα...