Searchable abstracts of presentations at key conferences on calcified tissues

ba0002p76 | (1) | ICCBH2013

Final height and bone health in young adults, transplanted in childhood

Dyck Maria Van , Herman Jean , Lombaerts Rita

: This study analyses the long-term effect of rhGH on final height (FH) and bone health in renal transplanted patients.Twenty-one young adult patients, aged 17–26 years, were studied. Group A consisted of 15 patients (12 boys) who received rhGH during 3.0 years before transplantation. After transplantation three boys needed rhGH again for 3.5 years. In group B six patients (three boys) didn’t need rhGH before transplantation, three girls receiv...

ba0002oc26 | Chronic diseases | ICCBH2013

Vertebral fractures in the 3-year period following steroid initiation among children with chronic illnesses

Miettunen P M , Taljaard M , Alos N , Atkinson S , Cabral D , Clarson C , Couch R , Cummings E A , Feber J , Grant R M , Lentle B , Matzinger M , Nadel H , Rodd C , Shenouda N , Stein R , Stephure D , Taback S , Rauch F , Siminoski K , Ward L M , the Canadian STOPP Consortium

Objectives: To describe the incidence of vertebral fractures in steroid-treated children.Methods: Fractures were assessed prospectively each year for 3 years according to the Genant semi-quantitative method. Proportions of children with incident fractures were determined annually over the study period. To examine associations with baseline clinical factors, the 3-year total number of incident fractures was analyzed using multivariable Poisson regression....

ba0003oc2.6 | Osteoporosis epidemiology | ECTS2014

Absolute fracture and mortality risk in patients with a recent non-vertebral fracture: the contribution of secondary osteoporosis or other metabolic bone disease (SECOB)

van Geel Tineke , Geusens Piet , Bours Sandrine , Wyers Caroline , van den Bergh Joop

Objective: To investigate whether patients with secondary osteoporosis or other metabolic bone disease (SECOB) have a higher re-fracture or mortality risk.Method: Patients with a recent non-vertebral fracture who visited the Fracture Liaison Service (FLS) of a hospital were prospectively followed for 2 years. Pearson Chi-square, Fisher’s Exact test, independent samples T-test, and Cox regression models were used.Results: In to...

ba0001pp37 | Bone biomechanics and quality | ECTS2013

Microarchitectural decay and microdamage accumulation in vertebral trabecular bone: a comparative analysis of the iliac crest, proximal femur, and vertebral body in the aged postmenopausal skeleton

Carpentier Vincent T , Muratovic Dzenita , Parkinson Ian H , Fazzalari Nick L , Kuliwaba Julia S

Study aim: The general assumption that changes in bone microstructure and material properties at the iliac crest are representative of skeletal sites that are susceptible to osteoporotic fracture has not yet been addressed. Therefore, our study aim was to perform a comparative analysis of bone microarchitecture, accumulated microdamage and osteocyte morphology between the iliac crest, proximal femur and vertebral body.Methods: Trabecular bone cores were ...

ba0001pp129 | Calciotropic and phosphotropic hormones and mineral metabolism | ECTS2013

The Ellsworth-Howard test revisited

Tang J C Y , Washbourne C J , Galitzer H , Hiemstra T , Meek C , Chipchase A , Fraser W D

Background: Pseudohypoparathyroidism (PHP) is a group of heterogeneous endocrine disorders characterised by hormone resistance, primarily to parathyroid hormone (PTH). The resistance is caused by defects in the GNAS gene, which encodes the Gsα protein that activates the cAMP pathway. PHP patients demonstrate elevated plasma PTH, hypocalcaemia, hyperphosphataemia with normal renal function. PTH resistance can be confirmed by Ellsworth-Howard test (PTH s...

ba0005p374 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Long term follow-up of fracture incidence and fracture prediction from bone mineral density

Trajanoska Katerina , de Jonge Ester A L , Kieboom Brenda C T , Mulder Marlies , Stricker Bruno H C , Franco Oscar H , Uitterlinden Andre G , Rivadeneira Fernando

Introduction: Due to the ‘greying’ of (industrialized) societies the incidence of osteoporosis and fragility fractures is expected to be increasing. Our aim was to investigate in an elderly population if the incidence of non-vertebral fractures (overall and site specific) has changed after a longer follow-up, and its relation with osteoporosis or osteopenia assessed by bone mineral density (BMD) at baseline.Methods: Incident non-vertebral fract...

ba0006is20 | (1) (1) | ICCBH2017

Canonical Wnt signaling in bone health and disease

Van Hul Wim

About two decades ago, evidence was generated that canonical Wnt signaling plays an important role in bone accrual mainly based on the identification of mutations in genes from the Wnt pathway resulting in extremely low or high bone mass. Since then, it became clear that genetic variation in a lot of genes from this pathway have an influence on bone mass both in a number of skeletal dysplasias as well as in the general population. This is the case for a number of wnt ligands (...

ba0005p35 | Bone biomechanics and quality | ECTS2016

Bone material properties as measured by Reference Point Indentation are low in subjects with acromegaly

Malgo Frank , Hamdy Neveen A T , Pereira Alberto M , Biermasz Nienke R , Appelman-Dijkstra Natasha M

Introduction: Acromegaly is a rare disease caused by excess growth hormone (GH) production by an adenoma of the anterior pituitary gland. The skeletal complications of GH and IGF-1 excess include increased bone turnover, increased cortical bone mass and deteriorated microarchitecture of trabecular bone, associated with a high risk of vertebral fractures in the presence of a relatively normal Bone Mineral Density (BMD). There are no data on bone material properties in patients ...

ba0002p114 | (1) | ICCBH2013

Association between parameters of bone mass measured by dual energy X-ray absorptiometry and quantitative ultrasound of proximal phalanges in children and adolescents with congenital adrenal hyperplasia

Goncalves Ezequiel M , Barbeta Vinicius J O , Bertapelli Fabio , Krahenbuhl Tathyane , Luiz Carlos B Ramalho , Martin Juan Eduardo Samur-San , Lemos-Marini Sofia H V , Guerra-Junior Gil

The chronic use of glucocorticoids in patients with congenital adrenal hyperplasia (CAH) may result in decreased bone mass. Therefore, using simple and accurate methods for assessing bone status in these patients could facilitate the treatment of disease. The purpose of this study was to verify the association between parameters of bone mass measured by dual energy X-ray absorptiometry (DXA) and quantitative ultrasound (QUS) of proximal phalanges in children adolescents with c...

ba0001pp237 | Cell biology: osteocytes | ECTS2013

Nucleotide and mechanically induced ATP release pathways in osteocytes

Kringelbach Tina M , Novak Ivana , Schwarz Peter , Jorgensen Niklas Rye

Background: We have previously shown that MLO-Y4 osteocytes express a number of P2 receptors, respond to a broad range of nucleotides (e.g. UTP) by increasing intracellular calcium concentration and release ATP upon both mechanical and UTP stimulation. The aim of this study therefore is to investigate how the osteocytes release ATP and whether there is a difference in release pathway depending on the type of stimulus.Methods: ATP release was investigated...