Bone Abstracts

Introduction: Vitamin D is essential for calcium metabolism as well as for fracture prevention. In children, low levels can cause rickets. A high prevalence of inadequacy in children has been reported in many studies. It is entirely prevalent in Lebanese children. There are different ways to detect cut-off points for vitamin D deficiency, The aim of this study was to describe the distribution of serum 25(OH)D levels in Lebanese children, males and females, to evaluate and prop...

Aim: The aim of this study was to assess the calcium daily food intake in Lebanese women living in South Lebanon, an under privileged area.Subjects and methods: Assessment of calcium food intake was performed with a validated questionnaire in 290 female patients attending clinics in two main referral health centers in South Lebanon.Results: The mean age of patients was 54.76 years and the mean BMI was 30.07 kg/sqm (S.D.</sma...

Despite the improvement in bone’s molecular, metabolic and live-cell imaging, histological investigation remains most crucial in bone biology for diagnostic and research purposes. Therefore, fixation of bone samples – especially for electron microscopy investigation – is critical to the ultrastructural analysis. Up to date, chemical fixation of bone tissue is performed at room temperature resulting in a compromised ultrastructure of bone sample. In this study, w...

Aims and background: Osteoporosis is a growing public health problem in developing countries. Awareness can lead to reduction in the incidence of the disease and consequently the fragility fractures.Osteoporosis knowledge is an important contributor to improving management and treatment of patients. The aim of this study was to measure osteoporosis knowledge among Lebanese physicians.Subjects and methods: Representative random samp...

Introduction: Vitamin D is essential for calcium metabolism as well as for fracture prevention. It plays a major role in bone health. A high prevalence of inadequacy has been reported in many studies. A serum 25-hydroxy vitamin D level of 30 ng/ml (75 nmol/l) has been proposed as the minimum for adequate vitamin D nutrition. The prevalence of inadequacy in different regions of the world has not been well characterized. The aim of this study was to evaluate and propose new base...

Aim: Low serum vitamin D levels are common in sunny Lebanon. Vitamin D is essential component of osteoporosis management strategies. This study surveys the referral rate of Lebanese males for vitamin D testing.Subjects and methods: A 13 000 Lebanese subjects included in this study were coming for routine check-ups. Patients on renal dialysis and cancer patients on chemotherapy were excluded. Serum 25-hydroxy vitamin D is considered the best indicator of ...

Introduction and aim: Vitamin D plays an important role in bone growth. In children, low levels can cause rickets. In adults, low levels can lead to osteoporosis and fragility fractures. The aim of this survey was to get information about vitamin D levels in Lebanese population.Subjects and methods: Serum 25-hydroxy vitamin D level is considered to be the best indicator of vitamin D status. 13 000 subjects included in this study were coming for routine c...

The healing of skeletal fractures involves a cascade of overlapping cellular events. This study aims to deepen the understanding of molecular networks orchestrating these events.Standard closed fracture in the left femur of male 8–10 weeks old C57BL/6N mice were analyzed at (day=D) D3, D7, D10, D14, D21 & D28 post fracture (N=5/time point). Total RNA was prepared for whole genome expression profiling using Illumina μ-array kit. Dat...

Purpose: The aim of our study is a micro-CT-based, longitudinal characterisation of ovariectomy, multideficient diet and corticoid therapy impact on the ossal microarchitecture.Materials and methods: Four randomized groups were formed out of 32 adult female merino land sheep:1. control2. ovariectomized (OVX)3. OVX+multideficient diet (OVX-D)4. OVX-D+320 mg methylp...

FDA guidelines recommend the sheep as large animal model for osteoporosis. Studies of osteoporosis induction use dual energy x-ray absorptiometry (DEXA) to evaluate bone status. Experimentally, the T-score is calculated based on reference bone mineral density (BMD) values of animals before treatment (0 M). Whereas clinically the reference BMD represents values of an independent group of patients around 30 years old. The study hypothesize that the use of additional ind...