Searchable abstracts of presentations at key conferences on calcified tissues

Bone Abstracts

Published by BioScientifica

Page 23 of about 3069 results

ba0001pp62 | Bone development/growth and fracture repair | ECTS2013

Intermittent administration of parathyroid hormone (1–34) may induce the formation of cementum and bone: a histological study in rats

Vasconcelos Daniel , Marques Marcelo , Barros Silvana , Vasconcelos Any Carolina , Benatti Bruno , Novaes Pedro

The aim of this study was to evaluate the effect of anabolic PTH on periodontal repair and mandibular bone defect in rats. Fenestration defects were created unilaterally of lower first molars in Wistar rats (n=32), and both periodontal ligament and cementum were removed. Animals were treated 3 times a week and then assigned to four groups (n=8): i) C14 – placebo administration for 14 days; ii) P14 – PTH administration for 14 days; iii) C21 – pl...
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ba0001pp63 | Bone development/growth and fracture repair | ECTS2013

Microtomography analysis of bone formation in calvarial defects filled with gelatin sponge or fibrin glue

de Santana Santos Thiago , Lopes Helena Bacha , Almeida Adriana Luiza , Beloti Marcio Mateus , Rosa Adalberto Luiz

Bone tissue engineering relies on the combination of scaffolds and cells aiming to heal bone defects. Among the many candidates for scaffolds, gelatin sponge (Gelfoam®) and fibrin glue (Tissucol®) are of interest due to the well-established biocompatibility and the ability to be loaded with cells. Here, we evaluated their potential to stimulate bone formation by microtomography analysis. For this, 5-mm unilateral calvarial defect was created in rats deeply anesthetiz...
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ba0001pp64 | Bone development/growth and fracture repair | ECTS2013

Abstract withdrawn....
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ba0001pp65 | Bone development/growth and fracture repair | ECTS2013

A novel biocompatible BMP6 carrier device for bone regeneration

Grgurevic Lovorka , Erjavec Igor , Jankolija Morana , Popek Irena , Olic Anamarija , Topic Smiljka Vikic , Verbanac Donatella , Peric Mihaela , Oppermann Hermann , Vukicevic Slobodan

Bone morphogenetic protein 6 (BMP6) is a member of TGF-β superfamily with a high potential to induce new bone and cartilage. Here we demonstrate that BMP6 compared to the BMP7 paralog has unique biological properties. Previously, we showed that BMP6 is more active at lower amounts then BMP7 because of increased resistance to noggin due to lysine in position 60. Next, we discovered that BMP6 binds to blood coagulum components, which when modified with calcium salt and a fi...
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ba0001pp66 | Bone development/growth and fracture repair | ECTS2013

The P2Y2 receptor restrains BMD during development

Syberg Susanne , Ellegaard Maria , Schwarz Peter , Jorgensen Niklas Rye

The P2Y2 receptor is a G-protein-coupled receptor and the natural ligands (ATP/UTP) strongly inhibit mineralized bone nodule formation by osteoblasts in vitro. We have earlier shown that overexpression of the P2Y2 receptor in vivo resulted in decreased bone mineral density (BMD), partially due to increased bone resorption, but also decreased formation (detected by serum bone markers and bone histomorphometry).This ...
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ba0001pp67 | Bone development/growth and fracture repair | ECTS2013

Hip fracture induces a transient appearance of circulating mesenchymal stem cells

Heino Terhi J , Sederquist Bettina , Aro Hannu T

We have previously demonstrated the presence of circulating mesenchymal stem cells (MSCs) in fracture patients. However, the exact time for their appearance in circulation remains unknown. Nine patients (five females, four males, age 70±12 years, range 55–89 years) with a fresh femoral neck fracture were recruited in the study, which was approved by the local ethical committee. Bone marrow (BM) sample drawn from the iliac crest of all patients served as the individua...
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ba0001pp68 | Bone development/growth and fracture repair | ECTS2013

Long bone phenotypic analyzes of a RANK transgenic mouse line

Baaroun Vanessa , Coudert Amelie , Marty Caroline , Castaneda Beatriz , Berdal Ariane , Descroix Vianney

Introduction: Bone metastasis pathophysiology is currently defined as a vicious circle. Indeed, tumor cells co-express RANK-L and its receptor, RANK, allowing their own proliferation and peritumoral bone resorption necessary to the lesion expansion. Odontogenic tumors, which occur within the jaw, seem to present the same pathophysiological characteristics. Thus, studying the impact on bone of RANK over-expression by the osteoclasts would permit a better understanding of those ...
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ba0001pp69 | Bone development/growth and fracture repair | ECTS2013

The sealing zone is not required for mineralized cartilage resorption during endochondral ossification and growth of long bone

Touaitahuata Heiani , Cres Gaelle , Blangy Anne

Introduction: Osteoclasts are the only cells with the capacity to degrade mineralized matrices, such as bone and calcified cartilage. During bone remodeling, osteoclasts secrete protons to achieve the acidic dissolution of hydroxyapatite to make bone collagen amenable to digestion by the proteases they produce. This requires the sealing zone, a ring of densely packed podosomes that surrounds the ruffled border, which is the secretion apparatus of the bone resorbing osteoclasts...
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ba0001pp70 | Bone development/growth and fracture repair | ECTS2013

A casein-based diet leads to a better bone status than a soy protein-based diet during moderate protein restriction in growing mice

Rouy Emilien , Laroche Norbert , Blachier Francois , Tome Daniel , Vico Laurence , Blais Anne

This study aims at determining if casein would lead to a better bone status than soy in the context of a moderate protein restriction (6% of total energy intake) in growing mice.Ten-week-old female Balb/C mice were divided in four groups of 15 animals. Two groups received 6% of their energy intake as protein, one as casein and the other as soy protein. The third group was a normal-protein control receiving 20% soy protein. The last group (positive contro...
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ba0001pp71 | Bone development/growth and fracture repair | ECTS2013

Accuracy errors in longitudinal QCT measurements of cortical thickness bone mineral density and bone mineral content using different segmentation techniques: a simulation study

Gerner Bastian , Museyko Oleg , Topfer Dominique , Engelke Klaus

Introduction: The quantification of cortical BMD and thickness in QCT images remains challenging due to the limited spatial resolution of CT scanners. We simulated the impact of longitudinal cortical BMD and thickness changes on accuracy of cortical measurements using three different segmentation algorithms.Methods: A step function of varying width d (cortical thickness) and height (cortical BMD) and an additional step representing trabecular BMD was con...
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Bone Abstracts
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