ECTS2013 Poster Presentations Calciotropic and phosphotropic hormones and mineral metabolism (33 abstracts)
Vitamin D in fragile elderly women with severe osteoporosis and uncontrolled hypertension
Ferdinando D’Amico 1, , Francesco Caronzolo 1 , Giovanni Gaglio 1 , Antonino Granata 1 , Giuseppina Lombardo 1 , Tiziana Pipicella 1 , Pippo Spatola 1 , Enzo Russo 1 & Alessandro Grippa 1
1Department of Geriatrics Hospital of Patti, Patti, Messina, Italy; 2School of Medicine University of Messina, Messina, Italy.
Introduction: Aim of this study was to evaluate connections between Blood Pressure values and hypovitaminosis D states in elderly women with severe osteoporosis.
Design and methods: The subjects were all >80: 63 women (mean age 84+3) affected by severe osteoporosis. In 26 women we discovered a new spinal fracture after treatment. Thirty-seven women had multiple spinal fractures (>3). Among subjects with severe osteoporosis we selected 37 patients affected by hypertension treated with RAS non-interfering drugs. The design of the study included the evaluation of: i) clinical measurement of blood pressure; ii) renin; iii) 25 hydroxycolecalciferol; and iv) parathormone (PHT). Blood Pressure (BP) control was considered for BP levels <130/85 mmHg. Renin normal value was 2.8–40 μlU/ml. 25 Hydroxycolecalciferol normal value was 10–30 ng/ml. The normal parathormone range was 10–65 ng/ml.
Results: In the women examined we detected: mean systolic blood pressure (SBP) 134 mmHg, mean diastolic blood pressure 92 mmHg. In 31 women with hypovitaminosis we detected secondary hyperparathyroidism. Thirty-four women had uncontrolled hypertension with mean values of SBP 141 and of DBP 93 mmHg. Subjects with hypovitaminosis D and hyperparathyroidism showed an increase of renin values compared to women with normal levels of parathormone. Consequently we detected that there was a connection in elderly patients with severe osteoporosis between variable factors like age, blood pressure, vitamin D, and PTH (P<0.001).
Conclusions: Through this study we can state that in subjects affected by severe osteoporosis there is a direct pathogenic link between parathormone and regulative mechanism of blood pressure. The clinic situation of secondary hyperparathyroidism and hypovitaminosis D also shows an increase in rennin values. A correction in treatment for hypovitaminosis D can influence the RAS systemic activity and con also influence the secondary hyparathyroidism treatment.
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