Searchable abstracts of presentations at key conferences on calcified tissues
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European Calcified Tissue Society Congress 2013

Lisbon, Portugal
18 May 2013 - 22 May 2013

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European Calcified Tissue Society Congress 2013, 18 - 22 May 2013; Lisbon, Portugal

Poster Presentations

Paediatric bone disease

ba0001pp502 | Paediatric bone disease | ECTS2013

Craniofacial consequences of high-dose zoledronic acid injections in onco-pediatric patients

Lezot Frederic , Chesneau Julie , Battaglia Severine , Brion Regis , Farges Jean-Christophe , Lescaille Geraldine , Castaneda Beatriz , Marec-Berard Perrine , Brugieres Laurence , Corradini Nadege , Heymann Dominique , Redini Francoise

Background: High zoledronic acid (ZOL) dose protocol, one of the most potent inhibitors of bone resorption, is currently evaluated in a phase III clinical trial in Europe for the treatment of malignant pediatric primary bone tumors. The impact of such an intensive treatment on the craniofacial skeleton growth is a critical question in the context of patients with actively growing skeleton, in the light of our previous studies evidencing that endochondral bone formation was tra...

ba0001pp503 | Paediatric bone disease | ECTS2013

High dickkopf-1 levels in sera and leukocytes from children with 21-hydroxylase deficiency on chronic glucocorticoid treatment

Brunetti Giacomina , Maria Felicia Faienza , Piacente Laura , Ventura Annamaria , Oranger Angela , Carbone Claudia , Benedetto Adriana Di , Colaianni Graziana , Mori Giorgio , Colucci Silvia , Cavallo Luciano , Grano Maria

Children with 21-hydroxylase deficiency (21-OHD) need chronic glucocorticoid (cGC) therapy to replace congenital deficit of cortisol synthesis, and this therapy is the most frequent and severe form of drug-induced osteoporosis. In the study we enrolled 18 patients (9 females) and 18 sex- and age-matched controls. We found in 21-OHD patients high serum and leukocyte levels of dickkopf-1 (DKK1), a secreted antagonist of the Wnt/β-catenin signaling pathway, known to be a key...

ba0001pp504 | Paediatric bone disease | ECTS2013

The serum levels of carboxylated and undercarboxylated osteocalcin in children with cystic fibrosis

Ambroszkiewicz Jadwiga , Sands Dorota , Gajewska Joanna , Chelchowska Magdalena , Laskowska-Klita Teresa

Introduction: Osteocalcin (OC) is the noncollagenous protein of bone matrix produced by osteoblasts which play an important role in bone metabolism. In its carboxylated form (c-OC) osteocalcin binds to hydroxyapatite in bone and plays a regulatory role in bone formation and mineralization. In contrast, undercarboxylated OC (uc-OC) binds less effectively to hydroxyapatite and a significant association has been found between fracture incidence and uc-OC in elderly subjects. Unde...

ba0001pp505 | Paediatric bone disease | ECTS2013

Associations between leptin, growth factors and bone turnover markers in prepubertal obese children

Gajewska Joanna , Ambroszkiewicz Jadwiga , Chelchowska Magdalena , Klemarczyk Witold , Kurpinska Patrycja , Weker Halina , Laskowska-Klita Teresa

Introduction: Obesity is the direct cause of a number of immediate problems during childhood. Among them the high prevalence of fractures and joint problems in obese children was observed. Leptin may influence the development and bone remodeling in children, but this phenomenon is not well understood. Therefore, we studied the relationships between leptin and bone turnover markers, growth factors and anthropometric parameters in obese children.Descriptio...

ba0001pp506 | Paediatric bone disease | ECTS2013

Body composition in 3- and 4-year-old preterm and full-term infants – preliminary data

Karczmarewicz Elzbieta , Czekuc-Kryskiewicz Edyta , Czech-Kowalska Justyna , Jaworski Maciej , Pludowski Pawel , Bulsiewicz Dorota , Kornacka Maria , Niezgoda Anna , Pleskaczynska Agata , Nowakowska-Rysz Monika , Dobrzanska Anna , Lorenc Roman

Introduction: The body composition at term equivalent age of infants born preterm is different than that of infants born at term.Aim: The aim of the study was to compare the body composition in preterm and full-term infants at age 3 and 4 years.Patients and methods: Total body bone mineral content (TBBMC, g), density (TBBMD, g/cm2), and body composition (fat mass – FM, g; lean body mass – LBM, g) were measured ...

ba0001pp507 | Paediatric bone disease | ECTS2013

Perceived activity capability in children and adolescents with osteogenesis imperfecta

Hagberg Maud , Lowing Kristina , Astrom Eva

Introduction: Osteogenesis imperfecta (OI) is a genetic disorder which mainly affects the collagen in the bone mass with fractures and deformities as the main symptoms. In OI there is a great variation in dysfunction related to the disease. Mobility and activities related to mobility are often most difficult. The objective for this study was to find a relevant, valid and reliable instrument to assess the children’s activity capability.Method and par...

ba0001pp508 | Paediatric bone disease | ECTS2013

Comparison of the bone densitometry and anthropometric parameters between the Ukrainian, Indian and Nigerian young male students, graduated in Lugansk State Medical University

Luzin V , Stklyanina L , Ushko Y , Ignatyev A

Objectives: To establish the average bone mineral density (BMD) and bone mineral content (BMC) in young male population from the different ethno-geographical groupsMaterials and methods: Estimations of the calcaneal BMD (g/cm2) and BMC (r), using on ALOKA-5.0 DXA machine among Indian (n=58) and Nigerian (n=72) male students (17–20 years), were done. The anthropometric program included body weight, height, shoulder and th...