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Bone Abstracts (2013) 1 PP445 | DOI: 10.1530/boneabs.1.PP445

ECTS2013 Poster Presentations Osteoporosis: treatment (64 abstracts)

Effectiveness of the active metabolite of vitamin D in the treatment of postmenopausal osteoporosis

Fedir Klimovitskiy 1 , Vladyslav Povoroznyuk 2 & Nataliya Balatska 2

1M. Gorky Donetsky National Medical University, Donetsk, Ukraine; 2D.F. Chebotarev Institute of Gerontology NAMS Ukraine, Kyiv, Ukraine.

The aim of the research was to determine the efficacy of alfacalcidol (Alpha D3 Teva) in the treatment of women with postmenopausal osteoporosis and vitamin D deficiency.

Methods: 20 women with systemic postmenopausal osteoporosis were examined. All patients had vitamin D deficiency (the average level of 25(OH)D in blood serum was (37.16 (24.9, 45.1)) nmol/l). Alfacalcidol was prescribed for 12 month in doses 1 μg. duration of observation was 12 months. Bone mineral density was examined by dual-energy X-ray absorptiometry ‘Prodigy’ (GE Medical systems, Lunar). 25(OH)D, iPTH and bone turnover markers were evaluated by Elecsys 2010 analyzer (Roche Diagnostics, Germany).

Results: Alfacalcidol therapy leads to significant decreasing of iPTH level (from (49.42 (35.16, 65.87)) to (38.85 (21.91, 54.98)) pg/ml (P<0.05). Markers of bone formation (Osteocalcin, P1NP) during treatment did not change. At baseline β-CTx level was (0.430 (0.271, 45.12)) and decreased to (0.383 (0.228, 0.589)) ng/ml in 12 month (P>0.05). During treatment BMD increased on 1.5% at the lumbar spine, on 5.2% at proximal femur, on 4.0% at the forearm, and on 10.3% at total body.

Conclusions: Alfacalcidol therapy leads to a significant reduction of iPTH level, inhibits bone resorption and leads to improvement of bone mineral density.

Volume 1

European Calcified Tissue Society Congress 2013

Lisbon, Portugal
18 May 2013 - 22 May 2013

European Calcified Tissue Society 

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