ECTS2013 Poster Presentations Other diseases of bone and mineral metabolism (48 abstracts)
Evidence of increased bone resorption in early post menopausal women with idiopathic hypercalciuria: study with biochemical markers and pQCT of the Tibia
Konstantinos Stathopoulos 1 , Ilias Bournazos 1 , Pelagia Katsimbri 2 , Andonios Partsinevelos 1 , Aristeides B Zoubos 1 , Panagiotis Papaggelopoulos 1 , Erato Atsali 1 & Grigoris Skarandavos 1
1Bone Metabolic Unit, 1st Department of Orthopedics, School of Medicine, University of Athens, ‘Attikon’ University General Hospital, Athens, Greece; 24th Department of Internal Medicine, ‘Attikon’ University General Hospital, Athens, Greece.
Aim: We explored the hypothesis that idiopathic hypercalciuria (IH) causes increased bone loss in early post-menopausal women.
Materials and methods: We studied 41 postmenopausal women with IH. Inclusion criteria: i) recently (<6 months) diagnosed and untreated IH, ii) postmenopausal status >2 years, and iii) normal renal function. Exclusion criteria: i) all causes of hypercalciuria other than IH and ii) use of any medication for osteoporosis 1-year prior study. All patients were assessed for serum and urine 24 h calcium, phosphorus, 25(OH) vit D, PTH, bone ALP, serum NTX, and CTX. We studied three age groups: 48–59 years (n=15), 60–69 years (n=21), and 70–79 years (n=5). Patients underwent tibia pQCT (XCT 2000 scanner, Stratec), three slices obtained at the 4% (trabecular bone), 14% (subcortical), and 38% (cortical) of tibia length. For each site we estimated bone mineral content, bone areas, cortical thickness, periostal and endosteal circumference, then compared results with our published tibia pQCT database of 219 age-matched healthy postmenopausal women. We performed statistical analysis: data expressed as mean±S.D.
Results: 73% of patients in the 48–59 years group (11/15) showed evidence of increased bone turnover (≥1 bone marker). They also had lower cortical bone mineral mass (256.54±39.95 vs 282.63±38.63 mg/cm, P=0.019), cortical area (220.4±33.34 vs 246.85±32.85 mm2, P=0.005), cortical thickness (3.90±0.81 vs 4.53±0.57 mm, P=0.0005), and greater endosteal circumference (45.27±8.11 vs 40.34±4.51 mm, P=0.001) than age-matched individuals.
Conclusions: Our results suggest that early post menopausal women with IH present increased bone resorption and bone loss than healthy age-matched women. These effects of IH on bone appear to be lost later in life.
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