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Bone Abstracts (2013) 1 PP487 | DOI: 10.1530/boneabs.1.PP487

ECTS2013 Poster Presentations Other diseases of bone and mineral metabolism (48 abstracts)

Preliminary study for the effect of PDGF or mesenchymal stem cells on tissue repair of cutaneous radiation injury

Soon Jung Hwang 1, , Tae Hyung Cho 3 , Beomseok Lee 3 , Ji Hye Oh 3 & In Sook Kim 3


1Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University, Seoul, Republic of Korea; 2Brain Korea 21 2nd Program for Craniomaxillofacial Life Science, Seoul National University, Seoul, Republic of Korea; 3Dental Research Institute, Seoul National University, Seoul, Republic of Korea.


Purpose: Osteoradionecrosis (ORN) of the mandible is a serious complication of radiation therapy, and preceded by soft tissue damage before bone loss appears. However, there is still no adequate treatment to heal the soft tissue damage of ORN. This study investigated the effect of PDGF-BB or mesenchymal stem cells (rMSCs) on radiation-induced soft tissue injury.

Methods: Rat model was designed to irradiate the skin of SD rats while sparing the body and internal organs by utilizing a non-occlusive skin clamp along with an X-ray image guided stereotactic irradiator. All wounds were created using the 50 Gy dose level both on the right and the left flank at a 100 cm source-to-surface distance. Next day, experimental groups were randomly divided into three groups (n=3–4, each group). Left side in a subject was administered by 8 μg PDGF-BB, rMSCs and combination of PDGF and rMSCs, while the right side was used as vehicle control. Each wound was analyzed by defining the percentage of the irradiated area ulcerated at given time points and histological observation.

Results: No systemic or lethal sequelae occurred in any animals, and all irradiated skin areas in the multi-dose trial underwent ulceration. Greater than 60% of skin within each irradiated zone underwent ulceration within 16 days. PDGF-BB treatment groups (only PDFG group or PDGF and rMSCs mixed group) improved healing quality more highly organized collagen fiber deposition in full-thickness compared with control group.

Experimental groups were all reached peak ulceration above 50%, with all healing significantly but incompletely by the 56-day endpoint compared with control group.

Conclusions: These results suggest that PDGF-BB or MSCs are an alternative as a treatment to heal soft tissue injury, highlighting future therapeutic options, particularly for patients suffering from an impaired capacity for ORN.

Volume 1

European Calcified Tissue Society Congress 2013

Lisbon, Portugal
18 May 2013 - 22 May 2013

European Calcified Tissue Society 

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