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Bone Abstracts (2013) 1 W4.2 | DOI: 10.1530/boneabs.1.W4.2

ECTS2013 Workshops Osteoclast activity and haematopoiesis (3 abstracts)

Are osteoclasts dispensable for haematopoietic stem cell maintenance and mobilization?

Claudine Blin-Wakkach


LP2M, CNRS, University of Nice Sophia-Antipolis, Nice, France.


Haematopoietic stem cell (HSC) niches are complex structures located in the trabecular regions of the bone in association with bone-lining osteoblasts (endosteal niches) or with perivascular primitive mesenchymal cells (perivascular niches). These cells provide molecular signals that control HSC fate in terms of self-renewal, proliferation, apoptosis, differentiation, homing, quiescence, etc. Osteoclasts have been implicated in HSC mobilization in response to stress or pharmacological treatments. The mechanisms involved are poorly characterized and raise some controversy, essentially because other monocytic cells have also been implicated in HSC mobilization. However, our results and those from the literature showed that modulation of osteoclast activity alters the interaction between HSCs and their niches. Moreover, we have demonstrated that functional osteoclasts are required for the formation of the HSC niche by controlling the maturation of osteoblasts that participate in this niche. Lastly, our recent data revealed that osteoclasts also control other cell types involved in the regulation of HSC niches.

In conclusion, osteoclasts are not only required for carving space for HSCs in the BM but they also regulate mesenchymal cells for their niche function. These data and more recent ones will be discussed during the presentation.

Volume 1

European Calcified Tissue Society Congress 2013

Lisbon, Portugal
18 May 2013 - 22 May 2013

European Calcified Tissue Society 

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