Searchable abstracts of presentations at key conferences on calcified tissues
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6th International Conference on Children's Bone Health

Rotterdam, The Netherlands
22 Jun 2013 - 25 Jun 2013

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6th International Conference on Children's Bone Health , 22 - 25 June 2013; Rotterdam, The Netherlands

Oral Communications

Chronic diseases

ba0002oc25 | Chronic diseases | ICCBH2013

Wnt/β-catenin: a candidate pathway for bone repair in neurofibromatosis type-1

Ghadakzadeh Saber , Nik Saeid Amini , Baht Gurpreet , Whetstone Heather , Alman Benjamin

Objectives: Skeletal abnormalities occur in half of the individuals with neurofibromatosis type-1 (NF1), usually in the first 2 years of life; the most difficult to manage is congenital pseudarthrosis of tibia (CPT, tibial non-union) which may lead to the amputation of the limb. Previous work in our lab identified that high levels of β-catenin early in fracture repair, result in a phenotype similar to CPT. There is data showing higher than normal β-catenin levels in ...

ba0002oc26 | Chronic diseases | ICCBH2013

Vertebral fractures in the 3-year period following steroid initiation among children with chronic illnesses

Miettunen P M , Taljaard M , Alos N , Atkinson S , Cabral D , Clarson C , Couch R , Cummings E A , Feber J , Grant R M , Lentle B , Matzinger M , Nadel H , Rodd C , Shenouda N , Stein R , Stephure D , Taback S , Rauch F , Siminoski K , Ward L M , the Canadian STOPP Consortium

Objectives: To describe the incidence of vertebral fractures in steroid-treated children.Methods: Fractures were assessed prospectively each year for 3 years according to the Genant semi-quantitative method. Proportions of children with incident fractures were determined annually over the study period. To examine associations with baseline clinical factors, the 3-year total number of incident fractures was analyzed using multivariable Poisson regression....

ba0002oc27 | Chronic diseases | ICCBH2013

Serum vitamin D level can affect the treatment outcome of whole-body vibration for low bone mass in girls with adolescent idiopathic scoliosis

Lam Tsz Ping , Cheung Franco Tsz Fung , Mak Queenie Wah Yan , Yu Fiona Wai Ping , Lee Kwong Man , Ng Bobby Kin Wah , Cheng Jack Chun Yiu

Objectives: Adolescent idiopathic scoliosis (AIS) was associated with low bone mass which, apart from being an important health issue that could persist into adulthood, was also a significant prognostic factor for curve progression in AIS. We have performed a randomized controlled trial on whole-body vibration (WBV) and reported its effect on increasing femoral neck areal bone mineral density (aBMD) mainly at the dominant leg. The objective of this study was to evaluate the ro...

ba0002oc28 | Chronic diseases | ICCBH2013

Bone mineral density at diagnosis determines fracture rate in children-treated according to the DCOG-ALL9 protocol

te Winkel Mariel Lizet , Pieters Rob , Hop Wim C J , Roos Jan C , van der Sluis Inge M , Bokkerink Jos P M , Leeuw Jan A , Bruin Marrie C A , Kollen Wouter J W , Veerman Anjo J P , de Groot-Kruseman Hester A , van den Heuvel-Eibrink Marry M

Objectives: To elucidate the incidence and risk factors of skeletal toxicity in children with ALL treated with the dexamethasone-based DCOG-ALL9 protocol.Methods: Prospectively, the cumulative incidence of fractures was assessed in 672 patients and compared between different subgroups using the log-rank test. Serial measurements of bone mineral density of the lumbar spine (BMDLS) were performed in 399 ALL patients using dual energy X-ray absor...

ba0002oc29 | Chronic diseases | ICCBH2013

Mineral metabolism, cortical volumetric bone mineral density and fracture risk in childhood chronic kidney disease

Denburg Michelle , Tsampalieros Anne , de Boer Ian , Shults Justine , Kalkwarf Heidi , Zemel Babette , Foerster Debbie , Stokes David , Leonard Mary

Background and Objectives: The relations among cortical volumetric bone mineral density (CortBMD) and comprehensive measures of mineral metabolism have not been addressed in chronic kidney disease (CKD). The aim was to identify determinants of CortBMD in childhood CKD. A secondary objective was to assess if CortBMD was associated with subsequent fracture.Design/participants: This prospective cohort study in children, adolescents and young adults (ages 5&...

ba0002oc30 | Chronic diseases | ICCBH2013

Alteration of wnt/β-catenin signaling in HIV-infected youths: a mechanism leading to impaired bone health?

Mora Stefano , Giacomet Vania , Puzzovio Maria , Maruca Katia , Stucchi Sara , Erba Paola , Capelli Silvia , Vigano Alessandra , Zuccotti Gian Vincenzo

Objectives: Impairment of bone mass accrual and alterations of bone metabolism is a common finding in HIV-infected youths. In particular, previous studies demonstrated higher bone formation and bone resorption rates in HIV-infected children and adolescents. Wnt ligands promote bone formation by stimulating osteoblast differentiation and their survival. Recent studies demonstrated that sclerostin (Scl) and dickkopf factor 1 (DKK-1), Wnt antagonists, are important negative regul...