Searchable abstracts of presentations at key conferences on calcified tissues
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6th International Conference on Children's Bone Health

Rotterdam, The Netherlands
22 Jun 2013 - 25 Jun 2013

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6th International Conference on Children's Bone Health , 22 - 25 June 2013; Rotterdam, The Netherlands

Oral Communications


ba0002oc13 | Diagnostics | ICCBH2013

Level of calcium intake modifies the correlation between parathyroid hormone and 25-hydroxyvitamin D: a proposal of adequate 25-hydroxyvitamin D levels in children

Reyes Maria Loreto , Molina Marcela , Escobar Raul , Hernandez Maria Isabel , Cavada Gabriel , Jr Camargo Carlos Arturo

Background: The ‘adequate’ level of 25-hydroxyvitamin D (25OHD) in children remains unclear. For bone outcomes, parathyroid hormone (PTH) is an important functional biomarker. Prior studies have shown too weak a correlation between 25OHD and PTH levels to determine adequate 25OHD level.Objective: To determine adequate 25OHD level(s) in children using a normal PTH value of 65 pg/ml while adjusting for calcium intake.Design...

ba0002oc14 | Diagnostics | ICCBH2013

What DXA measurement sites are best for bone health assessment in children? Effect of inter-machine differences on bone outcomes from the Bone Mineral Density in Childhood Study

Zemel Babette , Kalkwarf Heidi , Leonard Mary , Gilsanz Vicente , Lappe Joan , Shults Justine , Shepherd John , Oberfield Sharon , Winer Karen

Objective: Total body less head (TBLH) and spine are the recommended DXA sites for bone health assessment in children and adolescents. However, inter-machine differences will affect use and interpretation of results in clinical care and research applications. We examined BMC and areal-BMD (aBMD) at 4 skeletal sites among healthy children to identify the magnitude of inter-machine differences in Z-scores.Methods: BMDCS evaluated healthy participa...

ba0002oc15 | Diagnostics | ICCBH2013

Bone health index: Swiss children have less in the bank than a generation ago

Thodberg Hans Henrik , Martin David D , Caflisch Jon , Jenni Oskar

Objective: The aim of this study is to compare the bone health index (BHI) for healthy Swiss children born in 1955 with healthy Swiss children born a generation later.Method: BHI is derived from the cortical thickness in the three middle metacarpals. It is determined with the BoneXpert medical device, which automatically analyses a standard bone age hand radiograph. The measurement result is independent of the sharpness of the image. The image data are f...

ba0002oc16 | Diagnostics | ICCBH2013

Longitudinal analysis of volumetric density, size and strength towards the end of skeletal maturation in Gambian males habituated to low calcium intake

Schoenbuchner Simon , Prentice Ann , Sawo Yankuba , Ceesay Mustapha , Mendy Michael , Ward Kate

To understand differences in bone health between and within populations, it is crucial to characterise bone development during childhood and adolescence. Peak height velocity at age 16 and young adult height at age 23.5 years were recently reported in Gambian males accustomed to low calcium intake1. Our study aims to describe bone accrual after peak height velocity in the same population.We used peripheral quantitative computed tomography to m...

ba0002oc17 | Diagnostics | ICCBH2013

Determinants of bone mineral density in long-term adult survivors of childhood cancer

Klap B C , te Winkel M L , den Hoed M , van Waas M , Neggers S J C M M , Boot A M , Pieters R , Pluijm S M F , van den Heuvel-Eibrink M M

Objectives: Osteopenia is a complication of childhood cancer treatment but it is unknown to which extend this occurs in adult survivors, and which subgroups are at risk. We examined bone mineral density (BMD) and assed the relative importance of potential determinants of low BMD in very long-term adult survivors of childhood cancer.Methods: The single-center cohort study included 410 adult CCSs (median age at diagnosis: 6.6 years (range: 0–17 years)...

ba0002oc18 | Diagnostics | ICCBH2013

Trabecular bone score applied to normal children's lumbar spine DXA scans

Adams Judith , Marjanovic Elizabeth , Roberts Stephen , Mughal Zulf , Ward Kate

Trabecular bone score (TBS) extracts a texture parameter from pixel grey-level variations in DXA lumbar spine images. The TBS is claimed to be a measure of trabecular structure and was validated in an in-vitro study of vertebral bodies with micro-CT1. TBS has shown the potential for fracture pre-diction in adults2. However, data are sparse regarding the reliability and usefulness of TBS3 and the method has not previously been applied i...