Searchable abstracts of presentations at key conferences on calcified tissues
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6th International Conference on Children's Bone Health

Rotterdam, The Netherlands
22 Jun 2013 - 25 Jun 2013

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6th International Conference on Children's Bone Health , 22 - 25 June 2013; Rotterdam, The Netherlands

Oral Communications


ba0002oc1 | Epidemiology | ICCBH2013

The Amalgamated Paediatric Bone Density Study (The ALPHABET Study): the collation and generation of UK based reference data for paediatric bone densitometry

Crabtree Nicola , Machin Mike , Bebbington Natalie , Adams Judith , Ahmed Faisal , Arundel Paul , Bishop Nicholas , Fewtrell Mary , Hogler Wolgang , Mughal M Zulf , Rhodes Laura , Shaw Nicholas , Ward Kate

Understanding normal patterns of bone growth is important for optimising bone health in children and reducing osteoporotic fractures in later life. Recently published guidelines for bone assessment in children state that to predict fractures a technique should identify children at risk of clinically significant fractures and that dual-energy absorptiometry (DXA) is the preferred method of assessment. Despite these guidelines there is still inconsistency and lack of consensus r...

ba0002oc2 | Epidemiology | ICCBH2013

Fracture patterns and bone mass in South African adolescent–mother pairs: the Birth to Twenty Cohort

Thandrayen Kebashni , Norris Shane , Micklesfield Lisa , Pettifor John

Differences in fracture rates and bone mass in families and individuals of different ethnic origins may be due to differing lifestyles and/or genetic backgrounds. This study aimed to assess the associations of bone mass and fracture prevalence in adolescents with maternal bone mass and fracture history, and sibling fracture history.Data from 1389 adolescent-biological mother pairs from the Birth to Twenty (Bt20) longitudinal study were obtained. Question...

ba0002oc3 | Epidemiology | ICCBH2013

Pediatric differences in bone mineral density according to ethnic background in children: The Generation R Study

Medina-Gomez Carolina , Heppe Denise , Hofman Albert , Uitterlinden Andre G , Jaddoe Vincent , Rivadeneira Fernando

Aim: Differences in fracture risk between ethnic groups have been documented. The basis for these differences is yet incomplete and the age at what ethnic differences appear is uncertain. Assessment of bone health in pediatric populations could bring insights on factors compromising bone accrual. We describe here differences in total body bone mineral density (TB-BMD) in a unique setting of children of the same age, measured with the same device (iDXA) different ethnic backgro...

ba0002oc4 | Epidemiology | ICCBH2013

Maternal antenatal 25(OH)-vitamin D status is associated with offspring muscle strength at 4 years of age

Moon Rebecca , Sayer Avan A , Ntani Georgia , Davies Justin , Robinson Sian , Godfrey Keith , Inskip Hazel , Cooper Cyrus , Harvey Nicholas

Objectives: Serum 25(OH)-vitamin D (25(OH)D) concentration is known to influence muscle function in postnatal life. Maternal 25(OH)D status during pregnancy has been implicated in the fetal programming of bone and fat mass, but little is known about its role in determining offspring muscle development. We investigated the associations between maternal serum 25(OH)D concentration in pregnancy and offspring muscle mass and strength at 4 years.Materials and...

ba0002oc5 | Epidemiology | ICCBH2013

Novel musculoskeletal phenotypes during childhood for epidemiological studies

Batra Rajbir N , Harvey Nicholas C , Cole Zoe A , Taylor Pat , Cooper Cyrus C , Javaid M Kassim , The Southampton Women's Survey Study Group

Objectives: Bone, muscle and fat share common mesenchymal origins yet current methods separately examine lean, fat and/or bone content. We hypothesized specific musculoskeletal phenotypes derived from relative contributions of each tissue.Methods: Design: We obtained information from the 6-year follow-up of mother–offspring pairs within the Southampton Women’s Survey, a prospective population-based cohort study of 12 583 initially non-pregnant ...

ba0002oc6 | Epidemiology | ICCBH2013

Role of bone-associated loci identified in GWAS meta-analyses in the context of longitudinal pediatric BMD in European Americans

Zemel Babette , Kalkwarf Heidi , Li Mingyao , Deliard Sandra , Kim Celia , Qu Liming , Chiavacci Rosetta , Paulhamus Donna , Lappe Joan , Gilsanz Vicente , Hakonarson Hakon , Oberfield Sharon , Shepherd John , Voight Ben , Kelly Andrea , Grant Struan

Objective: With recent genome wide association studies (GWAS), ~70 loci have been robustly and reproducibly associated with adult bone density and/or osteoporosis. However, to date no systematic effort has investigated which of these loci operate early in life. We investigated whether these single nucleotide polymorphisms (SNPs) are associated with childhood areal bone mineral density (aBMD). In addition we determined if any of the associations were age dependent.<p class=...