Objective: Insuficient vitamin D supply defined as serum hydroxyvitamin D (25OHD) <20 ng/ml is considered as one of possibile cardiovascular risk factors among adults with hypertension. Furthermore, some data also suggest an independent association between vitamin D deficits and hypertension and obesity during growth. The aim of the study was to assess vitamin D status in children and adolescents with hypertension.
Methods: The cross sectional study was performed on a group of 99 subjects (43 girls and 56 boys) aged 8.417.6 years (mean: 12.1), stratified according to their values of blood pressure (BP). Blood samples were taken to determine 25OHD; anthropometric traits and BP measurements were carried out using standard methods and equipment. The study was performed after winter time i.e. in March 2012.
Results: Only 8% of all studied children and adolescents demonstrated vitamin D level above 20 ng/ml, whereas predominantly severe deficits were found (92%). Significant correlations were observed between 25OHD and systolic BP (r=−0.37, P=0.0003) and mean BP (r=−0.3, P=0.002). Children and adolescents with normal systolic BP had better supply with vitamin D compared with age- and sex-matched hypertensive pairs i.e. subjects with critically increased systolic BP (>90th percentile). The association (P=0.03) was independent of age, BMI and anthropometric parameters.
Figure 1 Correlation between mean blood pressure (Mean BP) and serum concentration of 25(OH)D in subjects aged 8–17 years.
Conclusions: Our findings show associations between decreased levels of serum 25OHD and hypertension in adolescents suggesting potential role of vitamin D deficits in the development of this condition. However, these relationships and possible causal links need to be investigated in further prospective studies including larger groups of pediatric patients.
22 Jun 2013 - 25 Jun 2013