Bone Abstracts

Blood vessels and bone display spatial and functional relationships. While the coupling of angiogenesis to bone formation during modeling situations is well documented, the vessels roles in bone remodeling, although widely acknowledged, remain poorly explored. In order to image and quantify the bone vessel network in rodents, we contrasted the vascular bed with barium sulfate, followed by histology or either conventional or synchrotron radiation micro-computed tomography. We s...

Angiogenesis is the main process mediating the expansion of the blood vessel network during development, tissue regeneration or in pathological conditions such as cancer. The formation of new endothelial sprouts, a key step in the angiogenic growth program, involves the selection of endothelial tip cells, which lead new sprouts. Angiogenic sprouting is induced by tissue-derived signals such as vascular endothelial growth factor (VEGF), which activates signaling by endothelial ...

All biological tissues, including bone, require vascular support to survive. In fact, bone is a highly vascularized tissue, although this aspect of bone is often overlooked. Extensive work has demonstrated that the blood vessels in bone are necessary for nearly all skeletal functions, including development, homeostasis, and repair. In addition, blood vessels lost due to trauma regenerate, and new bone tissue formed in response to injury is aggressively vascularized. As a conse...