Searchable abstracts of presentations at key conferences on calcified tissues
Bone Abstracts (2014) 3 PP160 | DOI: 10.1530/boneabs.3.PP160

ECTS2014 Poster Presentations Cell biology: osteoclasts and bone resorption (22 abstracts)

EEIG1 interacts with RANK receptor and positively regulates osteoclastogenesis

Eutteum Jung , Jin Hee Park , Han Kyung Choi & Soo Young Lee

Ewha Womans University, Seoul, Republic of Korea.

The receptor activator of NF-kB (RANK) and ITAM-containing adaptors have been identified as essential factors involved in osteoclast formation and bone remodeling, but their mechanisms and interacting factors have not yet been fully identified. Here we report that early estrogen-induced gene 1 (EEIG1), a novel RANK ligand (RANKL)-inducible protein, physically interacts with RANK and further associates with Gab2, PLCg2, and Tec/Btk kinases by RANKL stimulation. Overexpression of EEIG1 enhances osteoclastogenesis, whereas small hairpin RNA (shRNA)-mediated EEIG1 silencing inhibits osteoclast formation, which results from impaired RANKL-mediated PLCg2 phosphorylation and NFATc1 induction. In addition, the inhibitory peptide designed to block RANK–EEIG1 interaction showed decreased RANKL-induced bone destruction by reducing the numbers of osteoclasts. Hence, we have identified a novel RANK signaling component, which controls RANK-mediated osteoclast formation and which may provide the molecular target for a new therapeutic strategy.

Volume 3

European Calcified Tissue Society Congress 2014

Prague, Czech Republic
17 May 2014 - 20 May 2014

European Calcified Tissue Society 

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