Searchable abstracts of presentations at key conferences on calcified tissues
Bone Abstracts (2014) 3 PP171 | DOI: 10.1530/boneabs.3.PP171

ECTS2014 Poster Presentations Cell biology: osteoclasts and bone resorption (22 abstracts)

The purinergenic receptor P2Y14 is essential for RANKL-induced osteoclastogenesis

Jin Hee Park , Eutteum Jung & Soo Young Lee

Ewha Womans University, Seoul, Republic of Korea.

The P2Y14 (purinergic receptor P2Y, G protein coupled, 14) receptor for UDP-glucose and other UDP-sugars has been implicated in the regulation of the stem cell compartment as well as neuroimmune function. However, the role of P2Y14 in osteoclast formation is completely unknown. We found that RANKL selectively induced P2Y14 among seven mammalian P2Y receptors when analysed at both the mRNA and protein level, but inhibitors of the MAP pathway suppressed induction of P2Y14 proteins. Extracellular addition of UDP-sugars such as UDP-glucose, UDP-galactose, UDP-glucuronic acid, and UDP-N-acetyl glucosamine promoted RANKL-induced osteoclastogenesis, while P2Y14 downregulation by RNA interference inhibited osteoclast formation. Taken together, these results suggest that P2Y14 may act as the receptor for UDP-sugars in osteoclast precusors and may regulate RANKL-induced osteoclastogenesis.

Volume 3

European Calcified Tissue Society Congress 2014

Prague, Czech Republic
17 May 2014 - 20 May 2014

European Calcified Tissue Society 

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