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Bone Abstracts (2014) 3 PP203 | DOI: 10.1530/boneabs.3.PP203

Muscle, physical activity and bone

Sarcopenic obesity worsens bone strength: hip strength analysis in post-menopausal women

Antimo Moretti, Maria Teresa Giamattei, Alessandro de Sire, Giovanni Cannaviello, Francesca Gimigliano, Raffaele Gimigliano & Giovanni Iolascon


Department of Medical and Surgical Specialties and Dentistry, Second University of Naples, Naples, Campania, Italy.

Background: Among body composition phenotypes there is no consensus on definition and consequences of sarcopenic obese phenotype. The recommended method to quantify the muscle mass is the dual energy X-ray absorptiometry (DXA), based on measurement of total fat mass and appendicular lean mass. A high BMI may provide a great bone mineral density (BMD) in many individuals, but it does not guarantee optimal bone strength. The aim of our study is to investigate the influence of sarcopenic obesity on hip bone strength indices: femoral strength index (FSI), Cross-Sectional Moment of Inertia (CSMI), cross-sectional area (CSA), section modulus (Z) and buckling ratio (BR).

Methods: In this retrospective case–control study, participants were recruited among patients who were assessed for osteoporosis, using DXA method, from January 2011 to December 2013. Inclusion criteria were: post-menopausal women aged 50 years or older; BMI≥30 kg/m2. We classified all the included patients in sarcopenic obeses and non sarcopenic obeses following Newman’s criteria, based on appendicular lean mass adjusted for height and body fat mass (residuals). We performed a hip structural analysis (HSA) from hip DXA images to measure FSI, CSMI, CSA, Z and BR.

Results: We evaluated 127 women mean aged 63.50 years±8.69 S.D. (min. 50 years and max. 84 years) with a mean BMI of 34.27 kg/m2±4.01 S.D. (min. 30.04 and max. 53.97). Forty-five sarcopenic obeses patients (35.43%) had a mean FSI of 1.17±0.33 S.D., a mean CSMI of 9613 mm4±2403 S.D., a mean CSA of 134 mm2±23 S.D., a mean Z of 556 mm3±113 S.D. and a mean BR of 9.11±4.23 S.D. Eighty-two non sarcopenic obeses (64.57%) had a mean FSI of 1.30±0.30 S.D., a mean CSMI of 9886 mm4±1970 S.D. and a mean CSA of 135 mm2±21 S.D., a mean Z of 571 mm3±102 S.D. and a mean BR of 7.11±2.67 S.D.

Conclusions: In our cohort of post-menopausal women, sarcopenic obeses had worse bone quality and strength.

Volume 3

European Calcified Tissue Society Congress 2014

Prague, Czech Republic
17 May 2014 - 20 May 2014

European Calcified Tissue Society 

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