Bone Abstracts

Background: Patients with type 2 diabetes (T2DM) have an increased risk of osteoporotic fracture than controls without diabetes. The aim of this study was to compare the 10-year probability of hip fracture and a major osteoporotic fracture using the FRAX algorithm between Postmenopausal Korean women with and without type 2 diabetes mellitus.

Methods: We used data from the Fourth Korea National Health and Nutrition Examination Survey 2008–2009. The measurements of anthropometric parameters and bone mass were obtained using dual energy X-ray absorptiometry (DXA) (Discovery-W, Hologic, Inc., USA). Data was available for a total of 1687 postmenopausal women (1584 without T2DM and 103 with T2DM) aged 40–90 years old. The FRAX 10-year probability was computed using the algorithm available online at http://www.shef.ac.uk/FRAX (South Korea version). To compare the 10-year probability of osteoporotic fracture between the groups with and without adjustment for age and weight, a complex-Sample general linear model was used.

Results: Mean 10-year probabilities of fracture were similar between groups for major fractures (diabetic 8.9 (8.0, 9.9, 95% CI) vs non-diabetic 8.1 (7.8, 8.4, 95% CI), P=0.105) and hip fractures (diabetic 3.5 (2.7, 4.2, 95% CI) vs non-diabetic 2.9 (2.7, 3.1, 95% CI), P=0.161). After adjustment for confounding factors (age and weight), there was also no significant difference between the diabetic and non-diabetic group (major osteoporotic fracture: 8.4 vs 8.1, P=0.485 and hip fracture: 3.2 vs 2.9, P=0.346).

Conclusion: FRAX did not reflect higher major osteoporotic and hip fracture risk in Korean T2DM patients. T2DM might be considered for inclusion in future iterations of FRAX.