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Bone Abstracts (2014) 3 PP3 | DOI: 10.1530/boneabs.3.PP3

Arthritis and other joint diseases: translational and clinical

Bone loss in patients with early axial spondyloarthritis

Elena Gubar, Anna Bochkova, Alexander Smirnov, Tatiana Dubinina, Anastasia Diomina, Oksana Rumiantseva, Sergey Shubin, Svetlana Glukhova & Shander Erdes

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V.A. Nasonova Reserch Institute of Rheumatology, Moscow, Russia.


Objective: To examine bone mineral density (BMD) at the femoral neck (FN) and lumbar spine (LS) in patients (pts) with early axial spondyloarthritis (axSpA).

Methods: 73 pts (33 men and 40 women) with early axSpA were included in this study. Pts fulfilled ASAS criteria. Pts enrolled in the study had inflammatory back pain for < 5 years: mean disease duration 19.9±14.4 months. Mean age 28.3±6.4 years, mean BASDAI 4.1±1.9; mean ASDAS-CRP 2.7±1.3; 66 (90.4%) pts were HLA-B27 positive. Clinical data were collected and BMD was measured using dual energy X-ray absorptiometry (DXA) of the FN and LS (L2–4). Low BMD was defined as Z-score ≤−2 (at one site at least). High disease activity was assumed in cases where BASDAI ≥4, ASDAS-CRP ≥2.1.

Results: In all 73 pts mean Z-score was −0.9±0.75 for the FN and −0.9±0.95 for the LS. Low BMD (at one site at least) was found in 13 (17.8%) pts. 11 (15.1%) pts had BMD reduction of the LS, five (6.8%) pts had BMD reduction of the FN, bone loss in both LS and FN was found in three (4.1%) pts. There has been found an association between low BMD (at one site at least) and disease duration. There was a statistically significant difference (P=0.04) between the two groups of pts (disease duration 18.3±14.2 and 27.4±13.7 months). No association has been found between low BMD and age, gender, high disease activity (BASDAI, ADSAS), ESR, CRP.

Conclusions: 17.8% of young adults with early axSpA have low BMD. Bone loss was found to be associated with disease duration. This emphasizes the need for early intervention in axSpA.

Volume 3

European Calcified Tissue Society Congress 2014

Prague, Czech Republic
17 May 2014 - 20 May 2014

European Calcified Tissue Society 

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