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Bone Abstracts (2014) 3 PP303 | DOI: 10.1530/boneabs.3.PP303

Osteoporosis: treatment

Gastrointestinal issues and osteoporosis treatment: the medication use patterns, treatment satisfaction, and inadequate control of osteoporosis study (MUSIC-OS)

Jonathan Adachi1, Silvano Adami2, Bernard Cortet3, Alun Cooper4, Piet Geusens5,7, Dan Mellström6, Ankita Modi8, Shiva Sajjan8, Shuvayu Sen8 & Joop van den Bergh5,7


1St. Joseph’s Healthcare, McMaster University, Hamilton, Ontario, Canada; 2Rheumatology Section, Department of Medicine, University of Verona, Verona, Italy; 3Department of Rheumatology, University Hospital of Lille, Lille, France; 4Bridge Medical Center, Crawley, West Sussex, UK; 5Department of Rheumatology, Maastricht University, Maastricht, The Netherlands; 6Departments of Internal Medicine and Geriatrics, Gothenburg University, Göteborg, Sweden; 7Biomedical Research Institute, University Hasselt, Diepenbeek, Belgium; 8Merck & Co., Inc., Whitehouse Station, New Jersey, USA.


Objective: This multi-objective prospective observational study is intended to examine treatment patterns, occurrence of gastrointestinal (GI) complications and clinical and health outcomes in post-menopausal women with osteoporosis (OP) in Europe and Canada. This abstract presents the baseline results of the treated population.

Materials and methods: Post-menopausal osteoporotic women currently on treatment completed surveys intended to measure the incidence and prevalence of GI problems; the associations between GI problems and medication adherence, discontinuation or switching; the impact of GI problems on quality of life, treatment satisfaction and healthcare resource utilization; and estimate the proportion of participants with inadequately controlled osteoporosis. This survey was administered at study enrolment (baseline), and 3, 6 and 12 months after enrolment. The results of the baseline data are presented here.

Results: A total of 2959 patients were enrolled in the treated participant cohort. GI problems were prevalent in 69.4% of patients at baseline. 68.1% of participants reported any GI problem in the past 6 months. Patients with GI problems reported lower medication adherence than those without GI problems, with ADEOS scores of 18.6 and 19.1 respectively (≥20 indicates adherence). Patients with GI problems also reported lower quality of life than those without GI problems, with EQ-5D summary scores of 71 and 77.3 respectively (score of 100 indicating the highest quality of life). Additionally, patients with GI problems reported lower treatment satisfaction than those without GI problems, with OPSAT-Q scores of 78.6 and 84.6 respectively (score of 100 indicating highest treatment satisfaction). Finally, two-thirds of patients with fractures in the past three months utilized the emergency room, indicating high healthcare resource use.

Conclusion: Participants with GI problems have poorer treatment adherence to osteoporosis medications, lower treatment satisfaction and quality of life than those without GI problems. Fractures correlate with higher resource utilization.

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