Searchable abstracts of presentations at key conferences on calcified tissues
Bone Abstracts (2014) 3 PP82 | DOI: 10.1530/boneabs.3.PP82

Bone development/growth and fracture repair

Comparison of proportions of T lymphocyte subsets according to serum 25(OH) vitamin D levels in postmenopausal women

Byung Yeon Yu & Seon Yong Bang

20 views


Konyang University Hospital, Daejeon, Republic of Korea.


Many reports have proposed significant role of vitamin D on immune mediated disease. This study analyzed lymphocyte subsets according to serum 25(OH) vitamin D levels in postmenopausal women to determine the potential effect of vitamin D on immune-mediated disease.

On a prospective observational basis, we enrolled 31 postmenopausal women who underwent health checkup in our hospital. Peripheral blood drawn for the estimation of total T, B cell, NK cell count, proportion of CD3+, CD4+,CD8+, Th1, Th2, Th17 and Treg subsets of T lymphocyte after fasting on the morning. We also measured BMI, estrogen, fasting glucose, hs-CRP, lipid profile, serum 25(OH)D, calcium, phosphate.

The subjects were divided into three groups according to serum vitamin D levels. Proportion of CD4+(P=0.024) T cells were significantly decreased in three tertile group compared with one tertile group. Proportion of CD8+(P=0.004) T cells in three tertile group were significantly increased than that of the one tertile group and three tertile group. Also, CD4+/CD8+T cell ratio in one tertile group was significantly increased than that of the two tertile group and three tertile group. However there was no differences in total T, B, NK cell count, Th1, Th2 cytokine producing T cell population, Th17 and Treg cells according to vitamin D levels.

In this study, serum vitamin D levels in postmenopausal women is associated with changes in the peripheral CD4+, CD8+T cell compartment.

Volume 3

European Calcified Tissue Society Congress 2014

Prague, Czech Republic
17 May 2014 - 20 May 2014

European Calcified Tissue Society 

Browse other volumes

Article tools

My recent searches

No recent searches.

My recently viewed abstracts

No recent abstracts.