ISSN 2052-1219 (online)

Bone Abstracts (2015) 4 P64 | DOI: 10.1530/boneabs.4.P64

Peripubertal bone quality and density profile of Chinese adolescents in Hong Kong

Ka Yee Cheuk2, Franco Cheung1,2, WayneY W Lee1,2, Vivian Hung1,2, Elisa Tam1,2, Tsz Ping Lam1,2, Bobby K W Ng1,2, Simon K M Lee3 & Jack C Y Cheng1,2

1Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong, Hong Kong; 2Joint Scoliosis Research Center of the Chinese University of Hong Kong and Nanjing University, Hong Kong, Hong Kong; 3Lee Hysan Clinical Research Laboratories, The Chinese University of Hong Kong, Hong Kong, Hong Kong.

Objectives: This study aimed to evaluate detailed bone profiles during puberty for Chinese adolescents in Hong Kong using high-resolution peripheral quantitative computed tomography (HR-pQCT) and dual-energy x-ray absorptiometry (DXA).

Methods: 333 healthy girls and 231 healthy boys (12–16-years-old) were recruited from secondary schools. Areal bone mineral density (aBMD) of bilateral femoral necks were measured by DXA while bone quality parameters were measured by HR-pQCT at the non-dominant distal radius. Maturity was assessed by Tanner staging.

Results: While a general increasing trend in bone density across puberty was found in girls, no difference on aBMD and vBMD between Tanner 3 and 4 was noted in boys. aBMD were numerically higher in boys at Tanner 1–3 while the reverse was noted at Tanner 4–5 with the difference reaching statistical significance at Tanner 4 (Default 1). Trabecular vBMD was higher in boys whereas girls had higher cortical and total vBMD especially at Tanner 4–5. Total area, cortical perimeter and trabecular area were higher in boys than girls across all Tanner stages. In contrast, cortical area and thickness were higher in girls especially at Tanner 4–5. Trabecular bone volume fraction and number were higher in boys while trabecular separation was higher in girls at Tanner 3–5.

Conclusion: There were differences on bone quality and density profiles across puberty between genders. A general increasing trend in aBMD and vBMD was only found in girls. Gender differences in bone parameters at the cortical and trabecular compartment were notably detected. Whether these were due to discrepancy in linear growth that outpaces mineral accretion in boys and whether estrogenic effect on endosteal apposition was responsible for these findings warrant further studies.

The project was supported by General Research Fund (468411, 468809).

Disclosure: The authors declared no competing interests.

Figure 1 Dominant femoral neck aBMD in chinese boys and girls across puberty.

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