Searchable abstracts of presentations at key conferences on calcified tissues
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43rd Annual European Calcified Tissue Society Congress

Rome, Italy
14 May 2016 - 17 May 2016

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New Investigator Oral Communications

Abstract Presentations

ba0005ni1 | Abstract Presentations | ECTS2016

Rictor plays a critical role in bone mass and strength with the involvement of Mtorc2 pathway in osteoblasts

Liu Dong-mei , Zhao Lin , Liu Ting-ting , Jiao Pei-lin , Zhao Dian-dian , Shi Mei-Shu , Tao Bei , Sun Li-hao , Zhao Hong-Yan , Liu Jian-min

Mammalian target of rapamycin (mTOR) functions mainly in the form of two complexes, namely mTORC1 and mTORC2, which are distinct in their unique components, raptor and rictor. Here, we focused on bone phenotypes in mice with a specific deletion of rictor using a Cre recombinase gene whose expression was driven by the promoter of osteocalcin. All procedures involving mice were approved by the Institutional Animal Care and Use Committee of the local admin. DXA analysis showed a ...

ba0005ni2 | Abstract Presentations | ECTS2016

Circulating microRNAs in postmenopausal women with osteoporosis and vertebral fractures

Yavropoulou Maria , Anastasilakis Athanasios , Makras Polizois , Grammatiki Maria , Kotsa Kalliopi , Yovos John

Circulating microRNAs (miRNAs) are currently being investigated as novel biomarkers for osteoporosis and osteoporotic fractures. The aim of the present study was to investigate the differential expression of specific circulating micro RNAs known to regulate bone metabolism and homeostasis in postmenopausal osteoporotic women with and without vertebral fractures. For the analysis, miRNAs were isolated from the serum of 24 osteoporotic patients with at least one moderate vertebr...

ba0005ni3 | Abstract Presentations | ECTS2016

Tumor necrosis factor superfamily members in bone loss in men with end-stage chronic obstructive lung disease

Kochetkova Evgenia , Ugay Ludmila , Maistrovskaia Yuliya

Aim: To assess the relationships of serum osteoprotegerin (OPG), receptor-activator of nuclear factor-κB ligand (RANKL) and tumor necrosis factor-alpha (TNF-α) superfamily with bone composition in end-stage COPD.Methods: Body and bone composition, serum OPG, RANKL, TNF-α and its receptors (sTNFR I, sTNFR II), TNF-related apoptosis-inducing ligand (sTRAIL) levels were measured in 48 men end-stage COPD accepted for lung transplantation, and ...

ba0005ni4 | Abstract Presentations | ECTS2016

The correlation between number and population of bone marrow endothelial progenitor cells with bone mass and bone metabolism in the elderly

Cheng Qun , Lin Shangjin , Bi Bo , Fan Yongqian , Lin Weilong

Objective: Endothelial progenitor cells (EPCs) have the potential ability to differentiate into vascular endothelial cells and osteoblasts for angiogenesis and osteogenesis, however, the correlation between number and population of bone marrow EPCs with bone mass and bone metabolism in elderly is unknown.Methods: Trabecular bone were extracted from 11 patients with fragility fracture and eight patients with osteoarthritis during artificial hip replacemen...

ba0005ni5 | Abstract Presentations | ECTS2016

Altered bone metabolism after high fat diet and exercise: role of Wnt signaling and insulin resistance

Picke Ann-Kristin , Sylow Lykke , Moller Lisbeth L V , Kjobsted Rasmus , Richter Erik , Rauner Martina , Hofbauer Christine , Hofbauer Lorenz C

High fat diet (HFD), obesity, and physical inactivity characterize the modern lifestyle. This can lead to coronary heart diseases and type 2 diabetes mellitus. Recent studies have shown that these conditions frequently are associated with poor bone quality. However, the molecular mechanisms are poorly understood. To analyze the effect of HFD and exercise (EX) on bone homeostasis, we fed 6-week-old C57BL/6 mice a high fat (60% fat) or standard chow diet for 10 weeks (10–20...

ba0005ni6 | Abstract Presentations | ECTS2016

Multi-potency and immunosuppressive activity of mesenchymal stromal cells derived from human induced pluripotent stem cells

Roux Clemence , Saviane Gaelle , Pini Jonathan , Dihib Gihen , Nourhene Belhaid , Wakkach Abdel , Blin-Wakkach Claudine , Rouleau Matthieu

Tissue healing/reconstruction as well as exacerbated inflammatory diseases may benefit from stem cell based therapies. Ex vivo isolated tissue mesenchymal stromal cells (MSCs) displaying multi-potent activity and immune-regulatory functions were long ago proposed as therapeutic cells and already tested in many clinical assays. Nevertheless, their use may be restricted because of the few number that can be recovered from adult tissues, their limited in vitro e...

ba0005ni7 | Abstract Presentations | ECTS2016

Exposure to chronic stress induces bone loss via glucocorticoid signalling in osteoblasts

Henneicke Holger , Li Jing-Bao , Gasparini Sylvia J , Seibel Markus J , Zhou Hong

Chronic stress and depression are associated with alterations in the hypothalamic–pituitary–adrenal signalling cascade and considered a risk factor for bone loss and fractures. However, the mechanisms underlying the association between stress and poor bone health are unclear. Utilising a transgenic (tg) mouse model in which glucocorticoid signalling is selectively disrupted in mature osteoblasts and osteocytes (HSD2OB-tg mice), the current study examines t...

ba0005ni8 | Abstract Presentations | ECTS2016

Bone marrow adipose tissue and bone turnover in postmenopausal osteoporotic women and the effects of raloxifene

Beekman Kerensa , Heijer Martin den , Maas Mario , Bisschop Peter , Bravenboer Nathalie

Background: In postmenopausal osteoporosis, a loss of bone volume due to increased bone turnover is accompanied by a higher volume of bone marrow adipose tissue (BMAT). If this static relationship is based on a functional relationship, BMAT is a potential target for treating osteoporosis. While it is known that estrogen can reduce BMAT, it is still unknown whether raloxifene – a selective estrogen receptor modulator – can also reduce BMAT.Objec...

ba0005ni9 | Abstract Presentations | ECTS2016

Inflammatory conditions induces a new subset of osteoclasts that prime TNFα-producing CD4+ T cells

Ibanez Lidia , Abou-Ezzi Grazia , Ciucci Thomas , Amiot Vanessa , Mansour Anna , Roleau Matthieu , Wakkach Abdelilah , Blin-Wakkach Claudine

Chronic inflammatory diseases are characterized by a bone destruction mediated by an increased osteoclast (OCL) activity. OCLs are phagocytic cells arising from the myeloid lineage. Indeed, OCLs derive from monocytes (MN-OCLs) and, in an inflammatory context, they also derive from dendritic cells (DC-OCLs). Despite this origin, their role in the immune responses is still unclear. OCLs in steady state have been reported to act as antigen-presenting cells that activate CD8+...