Bone Abstracts

The main cause of the bone destruction in rheumatoid arthritis (RA) is a destructive act of aggressively growing pannus, growth and angiogenesis of which are caused by the proliferation of fibroblasts in the synovium (S) due to the activation of fibroblast growth factor (FGF).Objectives: To reveal relationships of FGF with ultrasonic and arthroscopic and proliferative-destructive histological figures in RA.Methods: Complete compreh...

Background: Osteoarthritis (OA), the prevalent joint-affecting disease characterized by cartilage damage, is the leading cause of disability in adults and contributes to the excess of morbidity and healthcare costs. We performed the current trial to evaluate biomarkers, specifically adiponectin in serum and synovial fluid, associated with cartilage damage severity assessed by arthroscopy, in patients with symptomatic knee osteoarthritis.Methods: The 40 s...

Objectives: Prospective case-controlled study assessing whether the incidence of loosening of implants in patients undergoing Total Knee Arthroplasty (TKA) is higher among those with Secondary Hyperparathyroidism (SP) at the time of index operation.Material and methods: Caucasian female patients with knee osteoarthritis who underwent TKA between November 2004 and March 2007 were enrolled. Exclusion criteria: endocrinopathies, rheumatoid or secondary arth...

Rheumatoid arthritis (RA) is an immune-mediated disease characterized by T cells activation and bone erosions that severely reduces patients quality of life; however a clear role for different T helper (Th) cells has not been established yet.This work aims to evaluate Th phenotypes, osteoclast (OCs) precursors cells and cytokines in peripheral blood of women affected by early RA (eRA) compared to healthy women matched for age. The study was approved by o...

Introduction: We recently showed that patients with primary Sjögren Syndrome (pSS) have significantly higher bone mineral density (BMD) in the lumbar spine and femoral neck compared with healthy controls. The majority of those patients (69%) were using hydroxychloroquine (HCQ), which may have favourable effects on BMD.Aim: To evaluate whether HCQ modulates human bone cells in vitro.Methods: Osteoblasts were differenti...

Objectives: Sex hormones and mechanical overload have been regarded as main causative factors in the pathogenesis of temporomandibular joint (TMJ) osteoarthritis. However, there was no report regarding the relevance of mechanical overload on the mandibular condyle with serum estrogen level. This study aimed to investigate changes of the mandibular condyle of TMJ in ovariectomized rat under increased loading, and to evaluate the inhibitory effect of systemic administration of 1...

Introduction: Low level of estrogen has regarded as a main contributing factor of temporomandibular joint (TMJ) arthritis in young women patients. However, there is lack of evidence about the occurrence of arthritis in knee joint (KJ) related with estrogen deficiency. This study aimed to investigate the effect of estrogen deficiency on the loaded and non-loaded bone area of TMJ or KJ.Method and materials: Total of 28 SD rats were allocated into two group...

Objective: Osteoarthritis (OA) is a degenerative, slowly developing joint disease. Although clinical indications of OA can vary among different definitions there is a general agreement that the disease is associated with cartilage narrowing. However, there is no general consensus about the threshold below which the joint space width (JSW)/joint space area (JSA) can be certain indicators for the state of OA. Therefore this study evaluates these limits to reveal quantitative inf...

Background and Objectives: Rheumatoid arthritis (RA) is a chronic disease characterized by severe bone destruction which has been associated with altered lipid metabolism. Apolipoprotein E (Apo E) is a lipoprotein mainly produced by macrophages. ApoE has been described as crucial in lipid metabolism but also as an important anti-inflammatory mediator regulating innate immunity and bone turnover. In the present study we investigated the role of Apo E in bone destruction during ...

Rheumatoid arthritis (RA) is characterised by periarticular bone destruction leading to permanent disability. Some other forms of arthritis, such as arthritis in systemic lupus erythematosus (SLE), rarely produce bone lesions. Corresponding to that, inactivation of Fas produces a murine SLE-like phenotype, but alleviates bone loss during antigen-induced arthritis (AIA). Aim of this study was to identify cell populations differentially regulated in non-resorptive vs. resorptive...

Introduction: Collagen induced arthritis (CIA) is a mouse model of rheumatoid arthritis marked by persistent inflammation and enhanced osteoresorption at the affected joints as well as systemic osteopenia due to increased activation of osteoclast progenitors (OCP). Abundantly secreted chemokines presumably attract OCPs to the inflamed sites. Our goal was to identify chemotactic signals important for OCPs recruitment in CIA.Methods: After obtaining approv...