ECTS2016 Poster Presentations Muscle, physical activity and bone (14 abstracts)
Bone and muscle metabolism in lung transplant recipients
Ursula Föger-Samwald 1 , Aleksandra Petrikic 1 , Wolfgang Gruther 2 , Gerold Ebenbichler 3 , Stefan Kudlacek 4 & Peter Pietschmann 1
1Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria; 2HealthPi, Vienna, Austria; 3Department of Physical Medicine & Rehabilitation, Medical Unversity of Vienna, Vienna, Austria; 4Department of Internal Medicine, Krankenhaus der Barmherzigen Brüder, Vienna, Austria.
Although it is well established, that quality of life improves in patients after lung transplantation (LTx), severe musculoskeletal complications may develop. The aim of this study was to evaluate differences in the muscle markers Myostatin and Follistatin and the bone markers Dickkopf-1 (DKK1), Sclerostin (SOST) and Periostin between LuTx recipients and healthy controls. From 38 LTx patients blood samples were taken when discharged from hospital (LTx1) and 6-9 months after discharge (LTx2). Moreover, serum samples from 30 age and gender matched control subjects were obtained. Serum levels of DKK1 and of Myostatin were significantly increased (DKK1: LTX1+152.8%, LTx2+100.3%; Myostatin: LTx1+22.7%, LTx2+28.1%) and SOST levels were significantly decreased (LTx1 −33.1%, LTx2 −26.3%) in LuTx patients compared to controls. Serum levels of Periostin were significantly increased after discharge (LTx1+90.4%). In conclusion, our data give evidence for impaired muscle and bone metabolism in patients after LuTx. Elevated levels of Myostatin in LTx patients likely indicate a catabolic state of muscle metabolism. High serum levels of DKK1 correspond to reduced bone formation, whereas low SOST levels might be due to low bone mass and consequently a low number of osteocytes.
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ISSN 2052-1219 (online)
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