Searchable abstracts of presentations at key conferences on calcified tissues
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43rd Annual European Calcified Tissue Society Congress

Rome, Italy
14 May 2016 - 17 May 2016

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Poster Presentations

Muscle, physical activity and bone

ba0005p258 | Muscle, physical activity and bone | ECTS2016

Pamidronate may prevent muscle protein breakdown in burns by indirectly affecting cytokines

Jay Jason W. , Herndon David N. , Finnerty Celeste C. , Andersen Clark R. , Klein Gordon L.

We have shown that the bisphosphonate pamidronate (P) given to children <10d post-burn prevents resorptive bone loss and muscle protein breakdown. We have also shown in vitro that Ca modulates the inflammatory response by altering mononuclear cell chemokine production. We hypothesized that P affects muscle protein breakdown by altering cytokine or chemokine concentration directly or indirectly by lowering blood ionized (i) Ca. We retrospectively analysed biomarker...

ba0005p259 | Muscle, physical activity and bone | ECTS2016

Myths and truths on dietary supplements and nutraceuticals for musculoskeletal health: a scoping review

de Sire Alessandro , Moretti Antimo , Teresa Giamattei Maria , Gimigliano Francesca , Iolascon Giovanni

Background: An inadequate intake of nutrients, low levels of physical activity, and chronic diseases contribute to reduce muscle mass and physical performance in elderly. WHO reported that number of individuals aged ≥60 years will triple in 2050, with the sub-population aged >85 years that will grow faster than the others. Market of nutraceuticals and dietary supplements is growing in Italy, in particular aimed to improve health in elderly. Objective of this scoping ...

ba0005p260 | Muscle, physical activity and bone | ECTS2016

Effects of calcifediol versus cholecalciferol on 25(OH)D3 serum levels, appendicular muscle strength, and physical performance in post-menopausal women

Moretti Antimo , de Sire Alessandro , Calafiore Dario , Gimigliano Raffaele , Gimigliano Francesca , Iolascon Giovanni

Background: Post-menopausal women generally present reduced serum levels of vitamin D, reduced VDR expression in skeletal muscle cells, and a gradual loss of muscle mass and muscle function. The relationship between serum 25-hydroxyvitamin D [25(OH)D3] levels and muscle strength has been extensively investigated, even though there is no agreement in literature. Therefore, aim of our study was to evaluate the effects of vitamin D on 25(OH)D3 levels, muscle strength, and physica...

ba0005p261 | Muscle, physical activity and bone | ECTS2016

Bone and muscle metabolism in lung transplant recipients

Foger-Samwald Ursula , Petrikic Aleksandra , Gruther Wolfgang , Ebenbichler Gerold , Kudlacek Stefan , Pietschmann Peter

Although it is well established, that quality of life improves in patients after lung transplantation (LTx), severe musculoskeletal complications may develop. The aim of this study was to evaluate differences in the muscle markers Myostatin and Follistatin and the bone markers Dickkopf-1 (DKK1), Sclerostin (SOST) and Periostin between LuTx recipients and healthy controls. From 38 LTx patients blood samples were taken when discharged from hospital (LTx1) and 6-9 months after di...

ba0005p262 | Muscle, physical activity and bone | ECTS2016

The role of vitamin D and exercises in correction of age-related skeletal muscle changes in postmenopausal women

Povoroznyuk Vladyslav , Dzerovych Nataliia , Povoroznyuk Roksolana

The aim of the study was to evaluate the role of vitamin D and exercises in correction of age-related skeletal muscle changes in postmenopausal women.Materials and methods: 38 postmenopausal women aged 53–82 years (mean age – 67.00±7.08 yrs) were examined. The women were divided into the following groups: A – control group (n=10), B – women who took an individually-targeted vitamin D therapy (n=11), C – wom...

ba0005p263 | Muscle, physical activity and bone | ECTS2016

Vitamin D level and hand grip strength as risk factors of actual fall in patients with lumbar spinal stenosis

Yang Jae-Ho , Kim Tae-Hyun , Hong Seong-Hwan , Kim Ji-Hye , Kang Young-Mi , Suk Kyung-Soo , Kim Hak-Sun , Moon Seong-Hwan , Lee Hwan-Mo

Study design: Prospective study.Objectives: The risk factors correlated with actual falls were assessed in patients with lumbar spinal stenosis.Materials and methods: In 201 patients (M:F 65:136) with symptomatic lumbar spinal stenosis, falls history within recent one year was investigated. The factors which were expected correlation with actual falls were evaluated together. Blood chemistry was performed to evaluate serum Vitamin ...

ba0005p264 | Muscle, physical activity and bone | ECTS2016

UK popular sports and hip differences on bone outcomes in adolescent male athletes: The PRO-BONE study

Vlachopoulos Dimitris , Barker Alan , Williams Craig , Knapp Karen , Metcalf Brad , Arngrimsson Sigurbjorn , Fatouros Ioannis , Gracia-Marco Luis

Sports specific training may have different impact on bone outcomes, and adolescence is a key period to optimize bone health. The aim was to examine hip differences on bone outcomes between osteogenic (football) and non-osteogenic (swimming and cycling) sports in adolescent males.One hundred twenty one males (13.1±0.1 years) volunteered to partake in this study that received ethics approval from the UK National Research Ethics Service. Participants ...

ba0005p265 | Muscle, physical activity and bone | ECTS2016

Effect of pinealectomy and resistance exercise on rats tibiae morphology, mineral quantification and mechanical parameters

Benites Mariana , Ueno Melise , Scaramele Natalia , Tsosura Thais , Oliveira Amanda , Chiba Fernando , Louzada Mario Jefferson , Sumida Doris

The exposition of shift workers to light at night supresses the melatonin (ME) production. ME supression may contribute to the development of osteoporosis, which can be prevented and treated by resistance exercise (RE). This study evaluated the effect of ME release supression by pineal gland (pinealectomy) and the RE on rats tibiae morphology, mineral quantification and mechanical parameters. The project was approved by the local ethics committee (protocol 2014-00939). Fourty ...

ba0005p266 | Muscle, physical activity and bone | ECTS2016

Inhibition of Cyclooxygenase 2 pathway modulates collagen synthesis of cytokine-stimulated fibroblasts from Ligamentum flavum

Kang Young-Mi , Kim Ji-Hye , Yang Jae-Ho , Lee Hwan-Mo , Moon Seong-Hwan

Introduction: Hypertrophy of ligamentum flavum (LF) induces narrowing of spinal canal which develops neurogenic claudication. Several mechanisms of LF hypertrophy have been suggested. Among them inflammatory cytokine play a crucial role in LF hypertrophy by increasing collagen synthesis. Cyclooxygenase-2 (COX-2) pathway shares inflammatory reaction from infection and arthritis. Selective COX-2 inhibitor (COX-2si) might modulates collagen synthesis via suppressing inflammatory ...

ba0005p267 | Muscle, physical activity and bone | ECTS2016

Altered bone metabolism after high fat diet and exercise: role of Wnt signaling and insulin resistance

Picke Ann-Kristin , Sylow Lykke , Moller Lisbeth L V , Kjobsted Rasmus , Richter Erik , Rauner Martina , Hofbauer Christine , Hofbauer Lorenz C

High fat diet (HFD), obesity, and physical inactivity characterize the modern lifestyle. This can lead to coronary heart diseases and type 2 diabetes mellitus. Recent studies have shown that these conditions frequently are associated with poor bone quality. However, the molecular mechanisms are poorly understood. To analyze the effect of HFD and exercise (EX) on bone homeostasis, we fed 6 week-old C57BL/6 mice a high fat (60% fat) or standard chow diet for 10 weeks (10-20 mice...

ba0005p268 | Muscle, physical activity and bone | ECTS2016

Association of frailty with vitamin D in elderly women

Alekna Vidmantas , Mastaviciute Asta , Kilaite Justina , Tamulaitiene Marija

Objective: To investigate the relationship of frailty with vitamin D in community dwelling elderly women.Materials and methods: A retrospective cross-sectional study was performed on women over 60 years who were not using vitamin D supplementations. Frailty status was defined using Fried’s criteria: weakness, low walking speed, low physical activity, weight loss, exhaustion. Participants were classified as robust, prefrail and frail if they scored 0...

ba0005p269 | Muscle, physical activity and bone | ECTS2016

Effects of inorganic phosphate and FGF23 on C2C12 myoblast cells

Raimann Adalbert , Dangl Alexander , Javanmardi Alireza , Ertl Alexandra , Egerbacher Monika , Greber-Platzer Susanne , Haeusler Gabriele

Background: Disturbance of systemic phosphate homeostasis is often associated with musculoskeletal dysfunction. Multiple factors related to the underlying condition such as calcium levels and endocrine mechanisms are thought to contribute. Distinct effects of inorganic phosphate itself as well as its main regulator FGF23 by activation of similar pathways have been shown in several cell types. We are not aware of any detailed investigations into their effect on the differentiat...

ba0005p270 | Muscle, physical activity and bone | ECTS2016

A new tapping screw design for anterior cruciate ligament reconstruction

El Khassawna Thaqif , Engelhardt Markus , Eldin Daghma Diaa , Malhan Deeksha , Kern Stefanie , Tushtev Kamen , Rezwan Kurosch , Hein Sebastian , Haack Janne , Morino Sergio , Wagner Ulrich , Heiss Christian

Interference fit fixation of soft-tissue grafts is in clinical focus to allow anatomic graft fixation which increases stability and graft isometry. Although clinical data show promising results with different screw materials, the issue of biodegradability, handling and stability in the first weeks remain under demand. The purpose of the present study was to investigate anterior cruciate ligament (ACL) reconstruction radiologically, biomechanically and histologically using dire...

ba0005p271 | Muscle, physical activity and bone | ECTS2016

Skeletal muscle mass is strongly correlated with total Hip BMD in premenopausal women

Lee Sara , Youm Hyun Sik , Song Hye-Kyung , Jeong Kyung-Ah , Kim Joung Sook , Chung Hyewon , Choi Hoon , Kang Byung-moon

Introduction: The significance of sarcopenia and low muscle mass are especially emphasized in these days. Sarcopenia is well known to highly correlate with fragility and increases the risk of falling in the elderly and an important risk factor for disability and mortality. Evidence of inter-relaionship of muscle with bone metabolism is increasing. Therefore we investigated the relationship between BMD and muscle mass among healthy Korean premenopausal women.<p class="abste...