Searchable abstracts of presentations at key conferences on calcified tissues
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43rd Annual European Calcified Tissue Society Congress

Rome, Italy
14 May 2016 - 17 May 2016

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Poster Presentations

Osteoporosis: evaluation and imaging

ba0005p285 | Osteoporosis: evaluation and imaging | ECTS2016

Postmenopausal osteoporosis: clinical and biological profile, about 70 cases

Janani Saadia , Nassar Kawtar , Rachidi Wafae , Mkinsi Ouafa

Introduction: Osteoporosis is a systemic skeletal disease characterized by low bone mass and micro-architectural deterioration of bone tissue leading to an increase in bone fragility and susceptibility to fracture. Bone is subject to the influence of exogenous and endogenous hormonal factors capable of modulating the activity of bone cells and mineralization, and also the mechanical stresses. Postmenopausal osteoporosis is the most common primitive osteoporosis. Its diagnosis ...

ba0005p286 | Osteoporosis: evaluation and imaging | ECTS2016

Trabecular bone score (TBS) and TBS adjusted FRAX are better indicators for morphometric vertebral fractures than bone mineral density in type 2 diabetic postmenopausal women

Choi Yong Jun , Ock So Young , Ji Hyung-Min , Won Ye-Yeon , Suh Chang-Hee , Kim Bom-Taeck , Lee Duk-Joo , Chung Yoon-Sok

Type 2 diabetes is associated with fracture risk but, paradoxically, greater bone mineral density. The trabecular bone score (TBS) has been proposed as an index of bone microarchitecture associated with bone quality. This study compared the performance of TBS, bone mineral density (BMD), original and TBS adjusted FRAX scores in the prediction of vertebral fractures (VFs) in diabetic patients. This cross-sectional study enrolled 169 Korean postmenopausal diabetic women. Lateral...

ba0005p287 | Osteoporosis: evaluation and imaging | ECTS2016

Indentification of the lumbar 1-4 and lumbar 2-4 bone mineral density in women

Shao Hongyu , Yu Wei , Sun Pengtao , Du Guiying

Introduction: Osteoporosis is a major bone disease among postmenopausal women. Measurement of BMD in the spine and hip is used as gold standard for the diagnosis of osteoporosis. ISCD recommended that posteroanterior L1-4 as the spine region of interest for BMD measurement. However, both L1-4 and L2-4 are used in the clinical and epidemiological studies. The aim of our study was to evaluate whether the differences of BMD between L1-4 and L2-4 would exist.<p class="abstext"...

ba0005p288 | Osteoporosis: evaluation and imaging | ECTS2016

Underreporting of vertebral fractures with and without edema on spinal magnetic resonance imaging in adult patients

Du Gui-Ying , Yu Wei , Sun Peng-Tao , Guan Wen-Min

Objective: To emphasize the clinical importance, and quantify the degree of underreporting of vertebral fractures (VF) with and without edema on spinal magnetic resonance (MR) imaging.Methods: All spinal MR images obtained for patients ≥45 years, hospitalized from 1/6/2014 to 31/12/2015 at a single tertiary-care institution, were retrospectively reviewed to identify prevalent VFs. VF and fracture severity were classified using Genant’s method....

ba0005p289 | Osteoporosis: evaluation and imaging | ECTS2016

Sleep apnea and bone mineral density

Monova Daniela , Monov Simeon , Stambolova Maria , Peneva Evgenya , Shumnalieva Ruska , Sichanova Ljuboslava

Introduction: Obstructive sleep apnea (OSA) is a common sleep-related respiratory disorder characterized by repeated episodes of apnea and hypopnea resulting in sleep fragmentation, nocturnal hypoxia and hypercapnia, and excessive daytime sleepiness. OSA has recently become a well-recognized problem in view of its high prevalence in the general population. OSA is associated with many endocrine disorders (hypogonadotropic hypogonadism, hypercortisolism, glucose intolerance). Th...

ba0005p290 | Osteoporosis: evaluation and imaging | ECTS2016

Gender similarities and differences in cross-sectional cortical and trabecular bone of femoral neck in elderly Chinese population

Wang Ling , Cheng Xiaoguang , Yu Aihong

Objective: We aim to investigate gender similarities and differences in femoral neck (FN) structure of elderly population by bone investigational tookit (BIT) of quantitative computed tomography (QCT).Material and methods: This cross-sectional study was part of China Action on Spine and Hip Status study, including 207 males aged 55–87 years and 400 females aged 55–96 years. QCT scans were performed in the hip for the subjects, and we used BIT s...

ba0005p291 | Osteoporosis: evaluation and imaging | ECTS2016

Prevalence of vertebral fractures kept constant in postmenopausal women in Beijing, China: peking vertebral fracture (PK-VF) study, 2007–2012

Jiajue Ruizhi , Jiang Yan , Wang Qiuping , Wang Wenbo , Pei Yu , Wang Xiran , Huang Wei , Zheng Xin , Ning Zhiwei , Wang Ou , Li Mei , Xing Xiaoping , Yu Wei , Xu Ling , Xia Weibo

Purpose: PK-VF study, being conducted in 2007–2008 and 2012–2013, was aimed to investigate the prevalence and 5-year incidence of vertebral fractures (VFs) in postmenopausal women aged 50 years or older in Beijing, China.Methods: In the 2007–2008 survey, we randomly selected a community-based population of 1825 postmenopausal women, of whom 952 women also participated in the 2012–2013 survey. Adopting the same sampling strategies as 2...

ba0005p292 | Osteoporosis: evaluation and imaging | ECTS2016

Association between plasma sphingosine 1-phophate levels and incident fractures in postmenopausal women: a 3-year follow-up observation study

Hun Lee Seung , Jin Bae Sung , Hee Ahn Seong , Kim Hyeon-Mok , Kim Beom-Jun , Koh Jung-Min

Sphingosine-1-phosphate (S1P) is a significant regulator of bone metabolism. Recently, we found that a high plasma S1P level is associated with low bone mineral density (BMD), high levels of bone resorption markers, and a high risk of prevalent vertebral fracture in postmenopausal women. We investigated the possibility that S1P is a predictor of incident fracture. A total of 263 postmenopausal women participated in this longitudinal study and received follow-up for a mean dura...

ba0005p293 | Osteoporosis: evaluation and imaging | ECTS2016

DXA in clinical practice: invest in quality to improve accuracy and clinical relevance

Cagnoni Carlo , Gandolfi Stefano , Bibbo Patrizia , Iofrida Mariana , Occhipinti Maria

Introduction: Dual X-ray Absorptiometry (DXA) is currently the best technique available to evaluate bone mass, enabling the diagnosis of osteoporosis, the prediction of fracture risk and monitoring.Clinical good practices consider as preferred measuring sites the lumbar (L1–L4) and proximal femur (neck and total). The vertebral morphometry is a quantitative method for the diagnosis of vertebral fractures based on measuring vertebral heights.<p...

ba0005p294 | Osteoporosis: evaluation and imaging | ECTS2016

Establishing an LRP5 mutant zebrafish (D. Rerio) model of bone acquisition

Shochat Chen , Harari Ram , Karasik David

Aim & background: Evidence from genetic studies of osteoporosis and fracture risk indicate that bone mineral density (BMD) is genetically controlled. The low-density-lipoprotein-related receptor 5 (lrp5) gene is a known co-receptor in the canonical Wnt bone formation regulatory pathway. Although mutations found in this gene have been shown to regulate BMD in humans, and Lrp5 knockout mice had reduced bone mass, its role in the bone development/bone acquis...

ba0005p295 | Osteoporosis: evaluation and imaging | ECTS2016

Risk factors for subsequent vertebral compression fracture following osteoporotic compression fracture

Soo Kim Sung , Hwan Kim Jin , Hoon Kim Jung , Wan Choi Byung , Hyun Lee Dong

Objectives: To evaluate risk factors of subsequent vertebral fracture following acute osteoporotic vertebral compression fracture.Methods: As a multicenter retrospective study, we recruited 135 patients treated for acute osteoporotic compression fracture with available spine image taken at 1-year follow-up in three hospitals. The patients were divided into two groups according to occurrence of subsequent vertebral fracture. Two groups were analyzed with ...

ba0005p296 | Osteoporosis: evaluation and imaging | ECTS2016

Predicting hip fracture type of elderly Asian patients with low-energy fall by volumetric BMD and femoral morphology from QCT

Su Yong-Bin , Cheng Xiao-Guang , Wang Ling , Ma Yi-Min

Introduction: Femoral neck fractures and trochanteric fractures are two major types of hip fractures. The BMD changing or hip strength analysis (HSA) of the two type fractures may be different. No research had focused on a large sample of Asian people. This study investigated the differences in BMD and morphologic features of the two type hip fractures of elderly Asian people from QCT.Methods: A total of 279 elderly Chinese patients with hip fractures du...

ba0005p297 | Osteoporosis: evaluation and imaging | ECTS2016

Dexamethasone produces both bone-loss and bone-spare effects in OPG−/− mice

Sheng Zhifeng , Zhang Yan , Zhou Yinhui , Wu Xiyu , Yuan Linqing , Ou Yangna , Liao Eryuan , Zhou Houde

The effects of dexamethasone on trabecular and cortical bone in OPG−/− mice were investigated in present study. Forty 6-month-old C57BL/6J female mice, including wt (n=20) and OPG knockout (OPG−/−, n=20), were randomdly divided into four groups and treated with either sterile normal saline or dexamethasone at 1 mg/kg by intramuscular injection 3 days per week. All mice were sacrificed at 4 weeks after these treatm...

ba0005p298 | Osteoporosis: evaluation and imaging | ECTS2016

Bone mass density, yes or no: the effectiveness of BMD test in decreasing the risk for hip fractures in different demographic groups in Israel

Steier Miriam , Shefer Galit , Hoshen Moshe , Feldman Becka , Balicer Ran

Background: Bone mass density (BMD) test is used for diagnosing osteoporosis and identifying patients at high risk for fractures. Hip fractures are one of the possible negative outcomes of osteoporosis. Previous studies have examined demographic variations in osteoporotic hip fractures in ethnic groups, but the predictive value of BMD for future fracture is unknown.Objective: To determine whether a BMD test is associated with a lower risk of first hip fr...

ba0005p299 | Osteoporosis: evaluation and imaging | ECTS2016

Bone geometry and microarchitecture in patients with anorexia nervosa: a possible role of mechanical loading on cortical bone structure

Frolich Jacob , Hansen Stinus , Al-Dakhiel Winkler Laura , Andresen Andreas , Hermann Anne Pernille , Stoving Rene K.

Objective: To assess the effect of mechanical loading in anorexia nervosa (AN) in vivo, by comparing bone geometry and microarchitecture in weight bearing versus non-weight bearing bone.Subjects and methods: A total of 26 female patients with AN, and 26 female controls matched on age and height were included. Bone geometry, volumetric bone mineral density (vBMD) and microarchitecture were assessed using HR-pQCT (Scanco Medical, Brütisellen,...

ba0005p300 | Osteoporosis: evaluation and imaging | ECTS2016

Bio-impedance and quantitative ultrasound to measure bone mineral density in post-menopausal women from a rural Mexican community

Blanco-Rodriguez Fernando , Ellis-Infante Nicole , Lopez-Rivas Victor , May-Kim Sherlin , Pickett Charlotte , Pacheco-Pantoja Elda

It is widely accepted that the “gold” standard method for diagnosis of osteoporosis is dual energy X-ray absorptiometry, to measure bone mineral content and bone mineral density (BMD). However in the last decades other less harmful and cheaper methods were developed. Among them bioelectrical impedance analysis (BIA) is one of most commonly used and is used in analysis of body composition as well. On its side, quantitative ultrasound (QUS) is a noninvasive method of e...

ba0005p301 | Osteoporosis: evaluation and imaging | ECTS2016

Association of serum vitamin D with bone mineral density and breastfeeding in post-menopausal women from a Mexican rural community

Ellis-Infante Nicole , Blanco-Rodriguez Fernando , Lopez-Rivas Victor , May-Kim Sherlin , Pickett Charlotte , Pacheco-Pantoja Elda

Vitamin D plays an important role for bone health, and is associated to the risk of osteoporosis development.The aim of the present work was to determine the association between serum vitamin D concentration and the bone mineral density (BMD) in post-menopausal women living in a Mexican rural community (this study was approved by the Institutional Ethics Committee). The BMD was assessed by ultrasound and vitamin D was evaluated using a specific immunoass...

ba0005p302 | Osteoporosis: evaluation and imaging | ECTS2016

A novel feature selection algorithm based on bone micro architecture analysis to identify osteoarthritis

Ljuhar Richard , Norman Benjamin , Ljuhar Davul , Haftner Tobias , Hladuvka Jiri , Bui Thi Mai Mary , Canhao Helena , MariaRodrigues Ana , Gouveia Nelia , Branco Jaime , Nehrer Stefan , Fahrleitner-Pammer Astrid , Dimai Hans-Peter

Objective: Texture information of the subchondral bone area (SBA) of 2D radiographs represents a promising possibility for evaluating the state of osteoarthritis (OA). However such features are likely to vary within the SBA and therefore the selection of the region of interest (ROI) plays a crucial role. Thus, a feature selection algorithm (FSA) is being applied in order to determine ROIs that enable an optimum discrimination between patients with and without OA.<p class="...

ba0005p303 | Osteoporosis: evaluation and imaging | ECTS2016

Heel quantitative ultrasound parameters, serum 25-hydroxyvitamin D and parathyroid hormone levels of healthy adult women in Greece

Grigoriou Efi , Kosmidis Christos , Dedousis Georgios , Dontas Ismini , Trovas Georgios

Objective: The objective of this observational cross-sectional study is to identify heel bone properties, specifically broadband ultrasound attenuation (BUA), speed of sound (SOS) and stiffness index (SI), in healthy Greek women, as well the relation of these parameters with age, serum 25-hydroxyvitamin D (25(OH)D) and parathyroid hormone (PTH).Material and Methods: A population of 738 community dwelling women was recruited at the health promotion events...

ba0005p304 | Osteoporosis: evaluation and imaging | ECTS2016

The comparison of bone scan and MRI in osteoporotic compression fractures

Kim Jin Hwan , Jang Bo Hoon , Kim Jung Hoon

Study Design: Retrospective study.Purpose: To estimate the usefulness of bone scan and magnetic resonance imaging (MRI) for the diagnosis of new fracture in osteoporotic vertebral fractures.Overview of Literature: The diagnosis of new fracture in osteoporotic vertebral fractures requires simple X-ray and supplementary studies.Methods: We analyzed 87 vertebrae in 44 patients, who diagnosed with osteoporotic ve...

ba0005p305 | Osteoporosis: evaluation and imaging | ECTS2016

The effect of cemented and uncemented implants on the measurement of proximal femur BMD by DEXA

Ding Yue , Fu Guangtao , Wang Kun , Zheng Qiujian , Lin Lijun , Sheng Puyi , Shen Huiyong , Liu Sheng , Liang Jiugen

Objective: To test the hypothesis that the cemented and uncemented implants had effect on the measurement of proximal femur BMD by DEXA.Methods: 40 patients underwent unilateral THA using cemented (n=20) and uncemented (n=20) implants due to developmental dysplasia of the hip, femoral neck fracture or femoral head necrosis from January 2015 to July 2015 were included. Preoperative DEXA scans were acquired for the BMD of the posteroanter...

ba0005p306 | Osteoporosis: evaluation and imaging | ECTS2016

To measure or not to measure? Vitamin D and parathyroid hormone in patients with clinical risk factors for osteoporosis

Bock Oliver , Pyttel Susanne , Dostmann Ute

Background: Despite the large amount of studies published on the association of vitamin D deficiency with higher incidence of falls and fractures, the threshold for a sufficient serum 25(OH)D concentration remains subject to a considerable debate. There has also been no clear consensus on the assessment and treatment of vitamin D deficiency.Objective: To examine the prevalence of vitamin D deficiency and/or insufficiency and its impact on calcium/phospha...

ba0005p307 | Osteoporosis: evaluation and imaging | ECTS2016

Bone mineral density and trabecular bone score in ukrainian women with obesity

Povoroznyuk Vladyslav , Dzerovych Nataliia , Martynyuk Larysa , Kovtun Tetiana

The aim of this study was to evaluate the bone mineral density (BMD), trabecular bone score (TBS) in the Ukrainian women with obesity.Materials and methods: 1025 women aged 40–89 years (mean age – 62.7±9.7 yrs; mean height – 161.4±6.2 cm; mean weight – 73.9±13.8 kg, body mass index – 28.4±5.1 kg/m2) were examined. The women were divided into the following groups depending on their body mass index: A...

ba0005p308 | Osteoporosis: evaluation and imaging | ECTS2016

The use of calcaneal quantitative ultrasound (QUS) combined with Asian osteoporosis self assessment tools (OSTA) in screening osteoporosis among postmenopausal women

Ding Yue , Zhang Yan , Shen Huiyong , Liu Heju , Liu Chunhai , Chen Qingyu , Zhang Chi , Fu Guangtao

Background: WHO recommends diagnostic criteria of osteoporosis can be based on double energy absorption of x-ray bone densitometry (DXA), but the DXA method has some limitations such as relatively higher cost, relatively longer detection time, inconvenience in equipment transportation and so on. Quantitative Ultrasound (QUS) method has the potential to diagnose osteoporosis and it is convenient to carry around and low-cost. Asian osteoporosis self-assessment tool (OSTA) is an ...

ba0005p309 | Osteoporosis: evaluation and imaging | ECTS2016

Tbs and calcaneal ultrasonography in people with down syndrome

Garcia Hoyos Marta , de Lamadrid Carmen Valero Diaz , Unzueta Carmen Garcia , L Lamosas Sheila Ruiz , Setien Isabel Sierra , Moral Jose Antonio Riancho

Individuals with Down syndrome (DS) have a number of phenotypic features, including a short stature. It has been reported that people with DS have lower areal BMD than the general population, but this may be a biased result due to the smaller size of the skeleton, and it is unclear if individuals with DS have fragile bones. Thus, the objective of this study was to explore the skeleton of DS using two techniques, TBS and calcaneal ultrasound, which are not influenced by bone si...

ba0005p310 | Osteoporosis: evaluation and imaging | ECTS2016

Hormone and hormone responsive stress-related molecules involved in osteoporosis in post-menopausal women

Dera Ayed , Barraclough Roger , Ranganath Lakshminarayan , Barraclough Dong

Osteoporosis is a metabolic disorder of the bones that shows increased incidence in post-menopausal women where estrogen deficiency plays a significant role in its development. Estrogen also decreases endoplasmic reticulum stress by decreasing the expression of ER stress markers.Using a combination of subtractive cDNA libraries and microarray analysis, a panel of estrogen dependent mRNAs/proteins was identified, including transcription factor, XBP1/1S; p...

ba0005p311 | Osteoporosis: evaluation and imaging | ECTS2016

Increased body weight as a risk factor of intertrochanteric fracture severity in elderly women

Ji Hyung-Min , Han Jun , Won Ye-Yeon

Purpose: Risk factors for intertrochanteric fracture (IF) severity were not studied thoroughly despite the high failure rate of osteosynthesis. The purpose of this study was to identify the risk factor for each fracture type using AO/OTA classification in elderly female patients who experienced IF.Materials and methods: This retrospective study identified 240 women over 50 years old with an incident IF in whom dual-energy x-ray absorptiometry (DEXA) was ...

ba0005p312 | Osteoporosis: evaluation and imaging | ECTS2016

Manganese distribution in bone tissue by SR-μXRF

Turyanskaya Anna , Rauwolf Mirjam , Roschger Andreas , Prost Josef , Pemmer Bernhard , Simon Rolf , Roschger Paul , Hofstaetter Jochen G. , Landete-Castillejos Tomas , Wobrauschek Peter , Streli Christina

Contemporary elemental imaging techniques are greatly contributing into the bone research. Synchrotron radiation induced confocal micro x-ray fluorescence technique (SR-μXRF) was employed for the analysis, being the most powerful and sufficient tool in detection and characterization of trace element distributions in bone tissue. Manganese (Mn), as a potential contributor into the mechanisms of calcium incorporation into bone tissue is in the spotlight of research. Further...

ba0005p313 | Osteoporosis: evaluation and imaging | ECTS2016

Changes of trabecular bone score in Asian females: comparison of 1990s and 2010s

Kim Young-Seong , Koh Miwon , Seok Choi Han , Hwan Kim Jin , Lee Taeyong

The purpose of this study is to understand the changes of TBS scores in Asian females by comparing 1990’s and 2010’s DXA images.We have compared the DXA images of 3774 Korean females (age: 20–79) to Japanese (age: 20–79). While Korean DXA images were obtained in 2014 and 2015, Japanese data were obtained in 1996. Participants who have abnormal DXA images or lumbar disease were excluded. TBSiNsight® software (v. 2.1.1, ...

ba0005p314 | Osteoporosis: evaluation and imaging | ECTS2016

Inducing osteoporosis in a large animal model: influence of ovariectomy, diet and corticoid therapy

Sender Jonas , El Khassawna Thaqif , Erdmann Georg , Bocker Wolfgang , Krombach Gabriele A. , Langheinrich Alexander C. , Kampschulte Marian

Purpose: The aim of our study is a micro-CT-based, longitudinal characterisation of ovariectomy, multideficient diet and corticoid therapy impact on the ossal microarchitecture.Materials and methods: Four randomized groups were formed out of 32 adult female merino land sheep:1. control2. ovariectomized (OVX)3. OVX+multideficient diet (OVX-D)4. OVX-D+320 mg methylp...

ba0005p315 | Osteoporosis: evaluation and imaging | ECTS2016

MRI analysis of the spine in 17 adults with WNT1 osteoporosis

Makitie Riikka , Niinimaki Tuukka , Nieminen Miika , Niinimaki Jaakko , Makitie Outi

Objectives: A heterozygous missense mutation p. C218G in WNT1 was recently identified as the cause of severe primary osteoporosis (Laine et al., New engl J Med 2013). The mutation has thus far been identified in two large Finnish families presenting with dominantly inherited, early-onset osteoporosis, with affected adult patients showing reduced bone mineral density (BMD), vertebral compression fractures, kyphosis and height loss. This study examined characte...

ba0005p316 | Osteoporosis: evaluation and imaging | ECTS2016

Correlations between trabecular bone score (TBS), sex, age, height, weight and bone mineral density (BMD): a study of the Korean population

Kim Young-Seong , Koh Miwon , Choi Han Seok , Kim Jin Hwan , Lee Taeyong

The purpose of this study is to assess the correlation of trabecular bone score (TBS) to variable factors, i.e. sex, age, body size and BMD. Moreover, we want to find variables of correlation coefficient change with aging.We randomly selected 2,906 subjects (1726 female and 1180 male, age range 20’s to 70’s) from several hospitals in Korea. Participants who have abnormal Dual Energy X-ray Absorptiometry (DXA) images or lumbar disease were exclu...

ba0005p317 | Osteoporosis: evaluation and imaging | ECTS2016

Cellular and extracellular investigations of healing parameters in a sheep model of osteoporosis

Schaefer Annemarie , Rosch Sebastian , Weisweiler David , Boecker Wolfgang , Lips Katrin S , Heiss Christian , Malhan Deeksha , Khassawna Thaqif El

Due to its huge socio-economic impact a better understating of osteoporotic fracture healing is crucial.Thirty-one female merino land sheep were randomly divided into four groups. (i) Untreated control-group (C, n=8); (ii) bilateral ovariectomy (OVX, n=7); (iii) OVX and calcium-deficient diet (OVXD, n=8); and (iv) OVXD and additional biweekly corticosteroid injections (OVXDS, n=8). Drill-hole defects (7.5 mm in diamete...

ba0005p318 | Osteoporosis: evaluation and imaging | ECTS2016

Circulating microRNA in metabolic bone diseases-osteoporosis

Mandourah Abdullah , Hof Rob Van' T , Ranganath Lakshminarayan , Barraclough Roger , Barraclough Dong

Osteoporosis is the commonest worldwide age-related bone disease. It is clinically symptomless until the first fracture happens. Circulating microRNAs can be used as novel biomarkers to assess health status and progression of complex diseases. A recent review highlighted the involvement of microRNAs in the control of bone formation and remodeling. Most of these studies have been done on animal models, but few on human blood samples.This research aims to ...

ba0005p319 | Osteoporosis: evaluation and imaging | ECTS2016

CORTEX; catching osteoporosis on routine tomography as an added EXtra

Barnes Polly , Blesic Karen , Johannesdottir Fjola , Skingle Linda , Poole Ken

Risk factors for osteoporosis are often present among patients referred for diagnostic CT scans. Recent UK Clinical Guidelines (NICE-CG146) promote the initial use of FRAX in the majority of patients at risk of osteoporotic fracture, in any health setting. We gained approval and NHS Innovation funding for a pilot service whereby patients undergoing a routine clinical CT scan of the abdomen or pelvis could be screened by estimating their 10-year fracture risk. Patient and radio...

ba0005p320 | Osteoporosis: evaluation and imaging | ECTS2016

Age and sex features of femoral geometry in patients with hip fractures

Grygorieva Nataliia , Zubach O

According to the literature data, some parameters of the femur (length of axis, length of femoral neck) are independent predictors of hip fractures, but such studies among Ukrainian patients are absent. The purpose of this study was to study age and gender features of some geometric parameters of the upper third of the hip in patients with intra- and extra-articular fractures of the femur.One hundred and seventy-four survey radiographs of the hip joints ...

ba0005p321 | Osteoporosis: evaluation and imaging | ECTS2016

The T-score standard in osteoporotic sheep model: insight into independent reference group

Khassawna Thaqif El , Engelhardt Markus , Weisweiler David , Bocker Wolfgang , Schmitt Jakob , Heiss Christian

FDA guidelines recommend the sheep as large animal model for osteoporosis. Studies of osteoporosis induction use dual energy x-ray absorptiometry (DEXA) to evaluate bone status. Experimentally, the T-score is calculated based on reference bone mineral density (BMD) values of animals before treatment (0 M). Whereas clinically the reference BMD represents values of an independent group of patients around 30 years old. The study hypothesize that the use of additional ind...

ba0005p322 | Osteoporosis: evaluation and imaging | ECTS2016

The essential role of bone biochemistry in the treatment of osteoporosis with rPTH therapy: a large study of over 450 patients

Casey Miriam , Healy Martin , McCarroll Kevin , Sidique Najia , Mahon James , Fallon Nessa , Walsh Bernard , Lannon Rosaleen

The effect of recombinant parathyroid hormone therapy as an anabolic agent has delivered great success in the treatment of osteoporosis. Although a treatment response is still defined in DXA terms, initial scans can fail to detect an increase in BMD since the collagen deposited in bone may not yet have mineralized. It is key therefore that an early response is detected biochemically and the physician can be reassured that the bone is not adynamic, the patient is compliant and ...

ba0005p323 | Osteoporosis: evaluation and imaging | ECTS2016

Trabecular bone score (TBS) and body composition analysis in liver transplantation patients at risk of new-onset diabetes (NODAT)

Martinez-Diaz-Guerra Guillermo , Librizzi Soledad , Guadalix Sonsoles , Allo Gonzalo , Jimenez Carlos , Hawkins Federico

Background: Previous TBS studies in type 2 diabetes have suggested a deterioration of bone microarquitecture that could be related to a higher risk of fractures. However, there are no information in liver transplantation (LT) patients with new-onset diabetes after transplantation (NODAT).Our aim was to investigate TBS in LT patients and the influence of NODAT in these patients. Also, we investigated the relationship between TBS and body composition param...