Bone Abstracts

After many years of study, researchers show that obesity can harm the bones. It is not known whether the increased fat mass can accelerate the process of bone loss. The aim of this study was to evaluate whether high-fat diet accelerates the process of bone loss in ovariectomized rats. This study was approved by the Ethics Committee of our Institution (188/2013). 40 female wistars rats with body mass of 60 g were used in this study. They were equally divided into four experimental groups which HFD45: ovariectomized rats fed with high-fat diet, they were killed 45 days after ovariectomy; HFD90: ovariectomized rats fed with high-fat diet, they were killed 90 days after ovariectomy; SD45: ovariectomized rats fed a standard diet, they were killed 45 days after ovariectomy; SD90: ovariectomized rats fed a standard diet, they were killed 90 days after ovariectomy. After the corresponding trial each group the rats were killed by overdose of anesthesia. The tibiae were evaluated when the BMD, Maximal Load. Statistical analysis was performed using SPSS. For BMD, the variable of diet was not influence (P=0.896) as well as the time variable (P=0.986). However, to Maximum Load the diet variable was not influent (P=0.146), but time was influential (P=0.015) and the interaction diet*time was influential (P=0.046). In conclusion, the high-fat diet does not accelerate the process of reduction in BMD, but accelerates the process of bone fragility in ovariectomized rats.