Bone Abstracts

Background: There have been many studies on the association between vitamin D and testosterone in the world. But it has not been fully clarified. Furthermore, data in Korean men is limited. This study aimed to determine the association between vitamin D and testosterone levels in korean men.

Methods: This cross sectional study analyzed serum 25-hydroxyvitamin D (25(OH)D) and total testosterone in 365 Korean men over 25 years of age who visited a local university hospital. To measure the level of serum 25(OH)D and total testosterone, venous blood samples were collected from the male subjects after a 12 hours overnight fasting. The association between serum 25(OH)D and total testosterone levels was analyzed using multiple regression analysis and partial correlation analysis.

Results: The subjects were divided into four groups according to serum 25(OH)D levels. The average age was 52.45±10.71 years, and the mean serum 25(OH)D and total testosterone levels were 19.42±8.73 ng ml⁻¹ and 5.09±1.81 ng ml⁻¹. Using multiple regression analysis, after fully adjusting for several factors (age, season, body mass index, waist circumference, skeletal muscle mass, body fat, systolic blood pressure, diastolic blood pressure, hypertension, diabetes mellitus, dyslipidemia, smoker, alcohol drinking, exercise, total cholesterol, fasting plasma glucose, prostate specific antigen, HbA1c, Calcium and Phosphate), 25(OH)D is not significantly associated with testosterone. (P=0.084). Also, in the partial correlation analysis 25(OH)D and total testosterone showed similar outcome after adjustments for confounders (P=0.05).

Conclusion: In conclusion, we demonstrated no association between serum 25(OH)D and total testosterone.

Keywords: 25-hydroxyvitamin D, total testosterone, Korean men