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Bone Abstracts (2016) 5 P284 | DOI: 10.1530/boneabs.5.P284

ECTS2016 Poster Presentations Nutrition (13 abstracts)

Is bone equally responsive to calcium and vitamin D intake from food vs supplements? Use of 41Calcium tracer kinetic model

Marta Van Loan 1 , Darren Hillegonds 3 , Tara Rogers 2 , Marjorie Garrod 2 , Janet Peerson 2 , Erik Gertz 1 , Elieke Demmer 2 & Bruce Buchholz 3

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1USDA, ARS, Western Human Nutrition Research Center, Davis, California, USA; 2University of California, Davis, California, USA; 3Lawrence Livermore National Laboratory, Livermore, California, USA


Few interventions directly compare equivalent calcium and vitamin D from dairy vs supplements on the same bone outcomes.

Objectives and Methods: Using 41Ca tracer techniques, determine if 4 servings/d of dairy foods reduces Ca excretion more than an equivalent amount of Ca and vitamin D from supplements. Secondary objective was to evaluate the time course for change in Ca excretion.

Design: In this crossover trial, postmenopausal women (n=12) were dosed orally with 100nCi of 41Ca and received dairy (4 servings/d dairy foods; ~1300 mg Ca, 400 IU vitamin D3/d) or supplements (1200 mg Ca carbonate/d, 400 IU vitamin D3/d) in random order. Treatments lasted 6 weeks separated by a 6 week washout (WO). Ca was extracted from weekly 24 h urine collections; accelerator mass spectrometry (AMS) was used to determine the urinary 41/40Ca ratio.

Results: Urinary 41/40Ca ratio decreased significantly with treatment, but there was no difference between treatments. The reduction in 41Ca excretion was observed in 1–2 weeks (P=0.0007 and P<0.001 for dairy and supplements, respectively). Return to pre-treatment excretion levels was observed within 1–2 weeks WO (P=0.0024).

Conclusion: These data suggest that changes in urinary Ca excretion with increases or decreases in Ca intake occur within 1–2 weeks; most likely via the miscible pool to maintain Ca homeostasis.

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Volume 5

43rd Annual European Calcified Tissue Society Congress

Rome, Italy
14 May 2016 - 17 May 2016

European Calcified Tissue Society 

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