Bone Abstracts

Purpose: Osteoporosis is a progressive bone disease that is characterized by a decrease in bone mass, density and destruction of microstructure, which can lead to an increased risk of fracture. Although many studies have been published about relationship between end-stage renal disease and osteoporosis, but research on the relationship between proteinuria and the prevalence of osteoporosis is still lacking.

Methods: We assessed 91 postmenopausal women with type 2 diabetes who visited our hospital from January 2009 to January 2012.

Results: Among 91 patients, prevalence of osteoporosis and osteopenia was 35.2% (32 cases) and 33% (30 cases) according bone mineral density. The patients with microalbuminuria and macroalbuminuria (ACR≥30) have a significantly higher incidence of osteoporosis compared to subject with normoalbuminuria (P<0.05).

Conclusion: This study indicates that urine ACR may be useful biomarkers for increased risk of osteoporosis in postmenopausal women with type 2 diabetes who has been linked to higher urine ACR levels.