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Bone Abstracts (2016) 5 P394 | DOI: 10.1530/boneabs.5.P394

ECTS2016 Poster Presentations Osteoporosis: treatment (40 abstracts)

Inhibitory effects of nanopartical calcium administration on dexamethasone-induced osteoporosis development in axial skeleton of pigs

Barbara Tymczyna 1 , Marcin Tatara 2 , Monika Tymczyna-Sobotka 3 , Witold Krupski 4 & Anna Szabelska 5

1Department of Conservative Dentistry and Endodontics, Medical University of Lublin, Karmelicka 7, Lublin, Poland; 2Department of Animal Physiology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, ul. Akademicka 12, Lublin, Poland; 3Department of Jaw Orthopaedics, Medical University of Lublin, Karmelicka 7, Lublin, Poland; 4II Department of Radiology, Medical University of Lublin, ul. Staszica 16, Lublin, Poland; 5Department of Prosthetic Dentistry, Medical University in Lublin, ul. Karmelicka 7, Lublin, Poland.

The aim of the study was to evaluate effects of 6-month-long administration with nanopartical calcium on morphological and densitometric properties of axial skeleton in pigs subjected to osteoporosis induction with dexamethasone. Male newborn piglets (N=28) were divided after birth into four equal groups (control group receiving placebo, Dex group receiving dexamethasone, NanoCa group receiving orally nanopartical calcium and NanoCa/Dex group) receiving simultaneously dexamethasone and nanopartical calcium. At the age of 6 months of life all pigs were sacrificed to obtain the second lumbar vertebra (L2) for analyses. Bone mineral density (BMD) and bone mineral content (BMC) were evaluated with the use of dual-energy X-ray densitometry (DEXA) method and Norland XR-46 apparatus, supplied with Research Scan software (Norland, Fort Atkinson, WI, USA), immediately after record of vertebral weight and vertebral body length (VBL). Statistical analysis of data was performed using one-way ANOVA and multiple comparison post hoc Duncan test. P<0.05 was considered as statistically significant. Dexamethasone administration significantly decreased VBL, BMD and BMC of L2 (P<0.05). Bone weight, VBL and BMC were significantly decreased in NanoCa Group when compared to the controls (P<0.05). Nanopartical calcium administration was effective to increase BMD and BMC of L2 in pigs receiving dexamethasone simultaneously (P=0.02 and P=0.01).

In conclusion, this study has shown positive effects of nanopartical calcium administration on densitometric properties of axial skeleton in pigs long-term treated with dexamethasone. The obtained results indicate that naopartical calcium administration may be effective for prevention and treatment of steroid-induced osteoporosis.

Volume 5

43rd Annual European Calcified Tissue Society Congress

Rome, Italy
14 May 2016 - 17 May 2016

European Calcified Tissue Society 

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