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Bone Abstracts (2017) 6 LB7 | DOI: 10.1530/boneabs.6.LB7

1Department of Pediatrics, Second Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czech Republic; 2Department of Probability and Mathematical Statistics, Faculty of Mathematics and Physics, Charles University in Prague, Prague, Czech Republic.

Background: Sarcopenia and osteoporosis are among the late complications of type 1 diabetes (T1D) in adults. Whether and to what extent musculoskeletal impairment is present in childhood and adolescence has yet to be determined. The aim of this study was to assess volumetric bone mineral density (BMD) and dynamic muscle function in adolescents with T1D and to assess the clinical and biochemical predictors of their musculoskeletal system.

Methods: Ninety-five children and adolescents (59 boys and 36 girls, mean age 16.2±1.2 years) with T1D were included in this cross-sectional study. Study participants were divided into two groups according to the duration of the disease (less than 6 years and more than 9 years, respectively). Volumetric BMD of the non-dominant tibia was assessed using peripheral quantitative computed tomography. Dynamic muscle function was evaluated using jumping mechanography. Gender- and height-specific Z-scores were calculated using published reference data. HbA1c was evaluated retrospectively as an average over the past 5 years.

Results: Relative muscle power (Pmax/mass) and force (Fmax/body weight) were significantly decreased in T1D subjects (mean Z-scores −0.4±1.0; P<0.001, and −0.3±1.1; P<0.01, respectively). The duration of T1D negatively affected Pmax/mass (P<0.01) but not Fmax/body weight (P=0.54). Trabecular BMD and the Strength-Strain Index were significantly lower in subjects with T1D (mean Z-scores −0.78±1.3 and −0.49±0.84, respectively, both P<0.001). Cortical BMD was significantly increased when compared to controls (Z-scores 1.2±0.90, P<0.001). No association was observed between the HbA1c and 25-hydroxyvitamin D levels, bone or muscle parameters.

Conclusion: T1D influences the musculoskeletal system in adolescence. Decreased muscle function could contribute to the osteoporosis reported in adult diabetic patients.

Disclosure: The authors declared no competing interests.

Volume 6

8th International Conference on Children's Bone Health


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