Searchable abstracts of presentations at key conferences on calcified tissues

Bone Abstracts

Published by BioScientifica
Previous issue | Volume 7 | ICCBH2019

9th International Conference on Children's Bone Health

Late Breaking Abstracts

(1)

Table of contents

ba0007lb1 | (1) | ICCBH2019

Genetic inactivation of osteocalcin in Col1a1Jrt/+ mice, a model of dominant osteogenesis imperfecta, restores glucose metabolism to wild-type levels

Tauer Josephine T , Komarova Svetlana V

Objective: Osteocalcin, an osteoblast-derived hormone, is among the most abundant proteins in bone and is involved in the regulation of whole-body metabolism, muscle adaptation, and reproduction. High bone turnover and low bone mass are clinical hallmarks of Osteogenesis Imperfecta (OI), a bone disease mainly caused by mutations in the collagen-I gene. Recently, we have shown that growing mice with a severe dominant form of OI, Col1a1Jrt/+ mice, displayed significantly elevate...
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ba0007lb2 | (1) | ICCBH2019

Lumbar spine quantitative computed tomography (QCT) is a better predictor of vertebral fracture in boys with Duchenne muscular dystrophy (DMD) than either DXA or peripheral QCT

Crabtree Nicola , Machin Michael , Padidela Raja , Kariki Eleni , Hughes Imelda , Shaw Nick , Mughal Zulf

Objectives: Vertebral fractures are common in boys with DMD taking daily corticosteroids. Treatment is usually initiated when vertebral fractures have been identified. However, prophylactic treatment may be possible if reliable risk factors for vertebral fracture can be identified. The aim of this work was to compare the diagnostic accuracy of three different bone strength assessment techniques in a cohort of DMD boys.Methods: Thirty-three boys with DMD ...
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ba0007lb3 | (1) | ICCBH2019

CD64: An adjunct to Kocher's criteria to differentiate septic arthritis and transient synovitis in children

Singh Ajai , Ali Sabir , Singh Satyendra

Objectives: To make a prediction model for septic arthritis on the basis to analyze CRP versus CD64 on neutrophils (nCD64) as an adjunct parameter to Kocher’s criteria to differentiate septic arthritis from transient synovitis.Methods: In this open ended prospective study, children (n=34) below 18 years of either gender (M=22/F=12) below 18 years presenting with acute, new onset, non – traumatic limp or joint pain were enrolled as case...
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ba0007lb4 | (1) | ICCBH2019

Impact of pubertal suppression on body composition and bone density in adolescents with gender dysphoria

Shepherd Sheila , Dewantoro Dixon , Ahmed Syed Faisal , Gerasimidis Kostas , Mason Avril , Shaikh Guftar , Wong SC , Kyriakou Andreas

Introduction: Pubertal suppression with gonadotrophin releasing hormone (GnRH) analogue is introduced after onset of puberty in adolescents with gender dysphoria (GD). As puberty is a critical period for bone accrual and changes in body composition, alterations in body composition and bone mass may be observed during treatment.Methods: Thirty-eight adolescents (32/38 assigned females at birth) with GD had dual energy X-ray absorptiometry (DXA) prior to s...
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ba0007lb5 | (1) | ICCBH2019

Chronic recurrent multifocal osteomyelitis in children with hypophosphatasia explained by anti-inflammatory nucleotidase activity of tissue nonspecific alkaline phosphatase in mesenchymal and hematopoietic cells

Bessueille Laurence , Briolay Anne , Como Juna , Mansouri Cylia , Gleizes Marie , El Jamal Alaeddine , Buchet Rene , Dumontet Charles , Matera Eva-Laure , Mornet Etienne , Millan Jose Luis , Fonta Caroline , Magne David

Deficiency in tissue nonspecific alkaline phosphatase (TNAP) causes hypophosphatasia (HPP), which is mainly characterized by skeletal hypomineralization. TNAP promotes mineralization by dephosphorylating the mineralization inhibitor inorganic pyrophosphate (PPi), which is generated from adenosine triphosphate (ATP) by ectonucleotide pyrophosphatase phosphodiesterase 1 (NPP1). Chronic recurrent multifocal osteomyelitis (CRMO), a sterile bone auto-inflammatory disease, has been ...
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ba0007lb6 | (1) | ICCBH2019

Abstract withdrawn....
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ba0007lb7 | (1) | ICCBH2019

Validation study of automated bone age assessment in 1285 children and adolescents aged 5 to 16 years

Maratova Klara , Zemkova Dana , Lebl Jan , Soucek Ondrej , Pruhova Stepanka , Kolouskova Stanislava , Snajderova Marta , Krasnicanova Hana , Sumnik Zdenek

Background: Skeletal maturation is the most reliable indicator of biological age in children and adolescents. The evaluation of hand and wrist X-Ray according to Tanner-Whitehouse (TW3) or Greulich-Pyle (GP) are the most commonly used methods for biological age assessment. Automated bone age assessment has recently become increasingly popular, however a large independent study comparing automated and manual evaluation of bone age is still missing. The aim of this study was to ...
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ba0007lb8 | (1) | ICCBH2019

Abstract withdrawn....
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ba0007lb9 | (1) | ICCBH2019

Monitoring skull base abnormalities in children with osteogenesis imperfecta

Wadanamby Shavinthi , Connolly Daniel , Arundel Paul , Bishop Nick J , Offiah Amaka

Objectives: In the context of a lack of national consensus, the aim of this study was to identify the clinical impact of skull base imaging in children with osteogenesis imperfecta (OI).Methods: A retrospective review was conducted of case-notes and radiological images of children with severe, complex and atypical OI at a designated specialist centre, between 01/2012 and 08/2018. Patient demographics, clinical features at time of imaging and radiological...
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ba0007lb10 | (1) | ICCBH2019

Foramen magnum stenosis (FMS): neuroradiological aspects before and after cervical decompression in paediatric patients with achondroplasia (ACH)

Allegri Anna Elsa Maria , Di Iorgi Natascia , Severino Mariasavina , Patti Giuseppa , Siri Giulia , Piatelli Gianluca , Fava Daniela , Napoli Flavia , Michelis Beatrice , Maghnie Mohamad

The identification of markers indicative of pathological FMS plays a pivotal role in the prevention of ACH complications.Objective: Identify key cranio-cervical junction neuroradiological features for the surgical choice and for the decompression outcome.Methods: Out of 191 ACH patients, we selected 24 patients before 4 years of age, who performed a first brain MRI and/or CT. Patients were divided into 2 groups: surgically treated ...
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Bone Abstracts
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