(1)

Abstract unavailable

ba0007p1

Treatment of partial growth arrest using cylindrical costal osteochondral graft

Orito Ryo

Orthopaedic Surgery Osaka University Graduate School of Medicine, Suita, Japan.

ba0007p2

Abstract unavailable

ba0007p3

Applicability of the Tanner-Whitehouse 3 method to United Kingdom children born in the 21st century

Alshamrani Khalaf Offiah Amaka

University of Sheffield, Sheffield, United Kingdom.

ba0007p4

Response of bone to mechanical stimulation in the offspring of MAVIDOS study mothers in a single centre; the effect of antenatal vitamin D supplementation

Gopal Sujatha Rigby Alan Moon Rebecca Cooper Cyrus Harvey Nick Harrison Rachel Bishop Nick

¹University of Sheffield, Sheffield, UK; ²Hull York Medical School, Hull University, Hull, UK; ³Department of Paediatric Endocrinology, University Hospital Southampton, Southampton, UK; ⁴MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; ⁵NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK; ⁶NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford; ⁷Sheffield Children’s NHS FT, Sheffield, UK.

ba0007p5

Pseudohypoparathyroidism type Ib initially masquerading as epileptic seizures due to Fahr's disease

Kutilek Stepan Plasilova Ivana

¹Department of Pediatrics, Klatovy Hospital, Klatovy, Czech Republic; ²Department of Pediatrics, Pardubice Hospital, Pardubice, Czech Republic; ³Department of Pediatrics, Faculty of Medicine and Faculty Hospital, Hradec Kralove, Czech Republic.

ba0007p6

Bone morphology patterns in children with osteogenesis imperfecta

Citron Kate Yonko Elizabeth Khan Sobiah Carter Erin Jepsen Karl Raggio Cathleen

¹Hospital for Special Surgery, New York, USA; ²University of Michigan, Ann Arbor, USA.

ba0007p7

Polyhydramnios: sole risk factor for non-traumatic fractures in two infants

Nadeau Genevieve Olivier Patricia Fiscaletti Melissa Campeau Philippe Alos Nathalie

CHU Sainte-Justine - University of Montreal, Montreal, Canada.

ba0007p8

Do lifestyle factors play a role on bone health in boys diagnosed with Autism Spectrum Disorder? Preliminary data from the Promoting bone and gut health in our children (PROUD) study

Duckham Rachel L Hyde Natalie K Brennan-Olsen Sharon L Hesketh Kylie Teo Wei-Peng Rodda Christine Walsh Adam Laing Emma M Lewis Richard D

¹Institute for Physical Activity and Nutrtion, Deakin University, Geelong, Australia; ²Australian Institute for Musculoskeletal Sciences (AIMSS), Western Health, St Albans, Australia; ³Epi-Centre for Healthy Ageing, Deakin University, Geelong, Australia; ⁴Department of Foods and Nutrition, The University of Georgia, Athens, USA.

ba0007p9

Radiographic evidence of zoledronic acid given during pregnancy - a case report

Peacock Amanda Offiah AC Balasubramanian Meena Bishop Nick Arundel Paul

¹Sheffield Children’s Hospital, Sheffield, UK; ²The University of Sheffield, Sheffield, UK.

ba0007p10

Reference values of cortical thickness, bone width, and Bone Health Index in metacarpals of children from age 0 y, as determined with an extension of the fully automated BoneXpert bone age method

Thodberg Hans Henrik Thrane Peter Martin David D.

¹Visiana Aps, Hørsholm, Denmark; ²Witten/Herdecke University, Germany; ³Tübingen University, Tübingen, Germany.

ba0007p11

Abstract unavailable

ba0007p12

Clinical implications of modeling the maturational spurt

Boeyer Melanie Leary Emily Sherwood Richard Duren Dana

¹University of Missouri, Department of Orthopaedic Surgery, Columbia, SC, USA; ²University of Missouri, Department of Pathology and Anatomical Sciences, Columbia, SC, USA.

ba0007p13

Bone health in children with congenital heart disease

Erlandson Marta Baril Chantelle Runalls Shonnah Lahti Dana Wright Kristi Pockett Chrissa Bradley Tim Kakadekar Ashok Pharis Scott Tomczak Corey

¹University of Saskatchewan, Saskatoon, Canada; ²Unviersity of Regina, Regina, Canada.

ba0007p14

TA-46 prevents premature synchondrosis and restores foramen magnum size in a mouse model of achondroplasia

Garcia Stephanie Rignol Guylene Goncalves Diogo Dellugat Pierre Tosello Lionel Marsault Raphael Stavenhagen Jeff Santarelli Luca Gouze Elvire

¹INSERM, Nice, France; ²Therachon SAS, Nice, France; ³Therachon AG, Basel, Switzerland.

ba0007p15

Higher neonatal bone mineral content and lower IL-6 levels in offspring of overweight/obese women following antenatal exercise: The IMPROVE randomized controlled trial (RCT)

Seneviratne SN Derraik JGB Jiang Yannan Gusso Silmara Rodrigues RO Peres Geovana Biggs Janene Craigie Susan McCowan Lesley Parry Graham Ekeroma Alec Cutfield WS Hofman PL

¹Department of Paediatrics, Faculty of Medicine, University of Colombo, Sri Lanka; ²Liggins Institute, University of Auckland, New Zealand; ³Department of Obstetrics and Gynacology, University of Auckland, New Zealand.

ba0007p16

Sex and maturation effects on trabecular and cortical microarchitecture in children and young adults

Aye Tandy Long Jin Kent Kyla Whalen Jessica Strickland Ariana Burghardt Andrew Leonard Mary B

¹Stanford School of Medicine Pediatrics, Palo Alto, CA, USA; ²UCSF, San Francisco, CA, USA.

ba0007p17

Bone mass and fracture prevalence in childhood brain cancer survivors (CBCS) 2 or 5 years after off therapy

Di Iorgi Natascia Gallizia Annalisa Mauro Vera Crocco Marco Garre Maria Luisa Maghnie Mohamad

¹Department of Pediatrics, Giannina Gaslini Hospital, Italy, Genova, Italy; ²University of Genova, Genova, IT; ³Department of Neuro-Oncology, Giannina Gaslini Hospital, Italy, Genova, IT.

ba0007p18

Progresive-deforming form of osteogenesis imperfecta in neonates - own experience

Jakubowska-Pietkiewicz Elżbieta Rusińska Agnieszka Michałus Izabela Chlebna-Sokoł Danuta Bartosik Paulina Woźniak Elżbieta Haładaj Katarzyna

Department of Pediatrics, Neonatal Pathology and Bone Metabolic Diseases, Łódź, Poland.

ba0007p19

Abstract unavailable

ba0007p20

Efficacy and safety of intravenous infusion of ibandronic acid in children with osteogenesis imperfecta

Awadalla Shokery

Pediatric Endocrinology, Bogota, Colombia.

ba0007p21

Tibia microarchitecture in children with recent fractures

Moon Rebecca Gillespie Tom Quiney Naomi Cooper Cyrus Harvey Nicholas Davies Justin

¹MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; ²Paediatric Endocrinology, University Hospital Southampton NHS Foundation Trust, Southampton, UK.

ba0007p22

What happens to the skeleton at the time of diagnosis of paediatric cancer?

Doulgeraki Artemis Nikita Maria Kanaka-Gantenbein Christina Baka Margarita Karavanaki Kyriaki Athanasopoulou Helen Polyzois George Tsentidis Charalampos Kossiva Lydia

¹Department of Bone and Mineral Metabolism, Institute of Child Health, Athens, Greece; ²Oncology Department, ‘P.&A. Kyriakou’ Children’s Hospital, Athens, Greece; ³Division of Endocrinology, Diabetes and Metabolism, 1st Department of Paediatrics, Medical School, National and Kapodistrian University of Athens, ‘Aghia Sophia’ Children’s Hospital, Athens, Greece; ⁴2nd Department of Paediatrics, Medical School, National and Kapodistrian University of Athens, ‘P.&A. Kyriakou’ Children’s Hospital, Athens, Greece; ⁵Department of Endocrinology, Metabolism and Diabetes Mellitus, Nikaea-Piraeus General Hospital ‘Agios Panteleimon’, Greece.

ba0007p23

The role of the RACK1-c-Src axis in regulation of osteoclast function

Park Jin Hee Jeong Eutteum Lee Soo Young

Department of Life Science, Ewha Womans University, Seolu, South Korea.

ba0007p24

Short term mechanical stimulation using whole body vibration identifies differences in bone response between prepubertal boys with and without prior fracture

Harrison Rachel Ward Kate Rigby Alan Gossiel Fatma Bishop Nick

¹University of Sheffield, Sheffield, UK; ²Sheffield Children’s NHS FT, Sheffield, UK; ³MRC Lifecourse Epidemiology Resource Unit, University of Southampton, Southampton, UK; ⁴University of Hull Medical School, Hull, UK.

ba0007p25

Parathyroid hormone is higher in infants with fracture as opposed to without fracture undergoing skeletal survey for suspected non-accidental injury, and is inversely associated with mean corpuscular haemoglobin content

Lewis Lindsay Alison Lilias Hardisty Hannah Parry-Okeden Sophie Bishop Nick

¹Sheffield Children’s NHS FT, Sheffield, UK; ²Chesterfield Royal Hospital, Chesterfield, UK; ³Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.

ba0007p26

Response to mechanical stimulation of bone in children with osteogenesis imperfecta and the effect of bisphosphonate therapy

Sithambaran Sivagamy Gopal Sujatha Harrison Rachel Gossiel Fatma Rigby Alan Bishop Nick

¹University of Sheffield, Sheffield, UK; ²Sheffield Children’s NHS FT, Sheffield, UK; ³Hull York Medical School, Hull University, Hull, UK.

ba0007p27

Duchenne muscular dystrophy: preliminary results of the Risbo-DMD study

Broggi Francesca Vai Silvia Baranello Giovanni Sansone Valeria Sansone D'Angelo Grazia Pane Marika Vita Gianluca Bianchi Maria Luisa

¹Experimental Laboratory for Children’s Bone Metabolism Research, Bone Metabolism Unit, Istituto Auxologico Italiano IRCCS, Milano, Italy; ²Unità Operativa Malattie Neuromuscolari, Fondazione Istituto Neurologico C. Besta IRCCS, Milano, Italy; ³Centro Clinico Nemo, Ospedale Niguarda, Milano, Italy; ⁴Istituto Medea IRCCS, La Nostra Famiglia, Bosisio Parini, Lecco, Italy; ⁵Dipartimento Neurologia Pediatrica, Policlinico Universitario Agostino Gemelli, Università Cattolica, Roma, Italy; ⁶UOC Neurologia e Malattie Neuromuscolari, Policlinico di Messina, Messina, Italy.

ba0007p28

Rib cage anomalies in a cohort of osteogenesis imperfecta patients

Zhytnik Lidiia Maasalu Katre Duy Binh Ho Prans Ele Reimann Ene Koks Sulev Martson Aare

¹Department of Traumatology and Orthopedics, University of Tartu, Tartu, Estonia; ²Clinic of Traumatology and Orthopedics, Tartu University Hospital, Department of Traumatology and Orthopedics, University of Tartu, Tartu, Estonia; ³Hue University of Medicine and Pharmacy, Hue University, Hue, Vietnam; ⁴Department of Pathophysiology, University of Tartu, Tartu, Estonia; ⁵Centre of Translational Medicine, University of Tartu, Tartu, Estonia; ⁶Perron Institute for Neurological and Translational Science, QEII Medical Centre, Nedlands, Australia.

ba0007p29

Bone mass, sclerostin and body composition in women with anorexia nervosa: a 3-year follow-up after weight gain therapy

Svedlund Anna Tubic Bojan Pettersson Cecilia Elfvin Anders Ellegard Lars Magnusson Per Swolin-Eide Diana

¹Department of Pediatrics, Institute for Clinical Sciences, The Queen Silvia Children’s Hospital, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden; ²Department of Orthopaedics, Institute of Clinical Sciences, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden; ³Anorexia-Bulimia Unit, The Queen Silvia Children’s Hospital, Sahlgrenska University Hospital, Gothenburg, Sweden; ⁴Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, The Sahlgrenska Academy at the University of Gothenburg, Sweden; ⁵Department of Clinical Chemistry, Linköping University, Linköping, Sweden.

ba0007p30

Determinants of survival in osteogenesis imperfecta (OI) Type II

Nadar Ruchi Saraff Vrinda Hogler Wolfgang Desai Maya Shaw Nick

¹Birmingham Children’s Hospital, Birmingham, UK; ²Johannes Kepler University, Linz, Austria.

ba0007p31

Successful use of oral acetazolamide in symptomatic subcutaneous calcifications in hyperphosphatemic tumoral calcinosis

Nadar Ruchi Saraff Vrinda Randell Tabitha Ryan Fiona Shaw Nick Hogler Wolfgang

¹Birmingham Children’s Hospital, Birmingham, UK; ²Nottingham University Hospital NHS Trust, Nottingham, UK; ³John Radcliffe Hospital, UK; ⁴Johannes Keppler University, Linz, Austia.

ba0007p32

Unusual case of severe hypophosphataemic rickets and renal stones associated with valproate use

Pintus Donatella Bhowmik Sudeshna Ramakrishnan Renuka

¹Alder Hey Children’s Hospital, Liverpool, UK; ²Arrowe Park Hospital, Upton Wirral, UK.

ba0007p33

Bone metabolism and bone mineral density in Duchenne muscular dystrophy

Bautembach-Minkowska Joanna Śledzińska Karolina Wierzba Jolanta Myśliwiec Małgorzata

Medical University of Gdańsk, Gdańsk, Poland.

ba0007p34

Atypical fractures in pediatric patients with osteogenesis imperfect treated with zoledronic acid

Lucia Bremer Alheli Clark Patricia

Hospital Infantil De Mexico Federico Gómez, Mexico City, Mexico.

ba0007p35

ALPL gene mutation in a family

Vai Silvia Broggi Francesca Luisa Bianchi Maria Ponti Emanuela Mihalich Alessandra Maria Di Blasio Anna

Istituto Auxologico Italiano, IRCCS, Milano, Italy.

ba0007p36

Generation of osteogenesis imperfecta type XIV zebrafish models

Leoni Laura Tonelli Francesca Cotti Silvia Giannini Gabriella Daponte Valentina Gioia Roberta Besio Roberta Garibaldi Nadia Rossi Antonio Forlino Antonella

University of Pavia, Pavia, Italy.

ba0007p37

Clinical features and approach to treatment in pediatric patients with McCune-Albright syndrome: monocentric experience

Makazan Nadezhda Orlova Elizaveta Kareva Maria Kolodkina Anna Kalinchenko Natalia Petrov Michael Zubkova Natalia Peterkova Valentina

Endocrinology Research Centre, Moscow, Russian Federation.

ba0007p38

Bone health outcomes in children with Duchenne Muscular Dystrophy

Chua Verene Munns Craig Biggin Andrew

¹The University of Sydney Children’s Hospital Westmead Clinical School, Sydney, Australia; ²The Children’s Hospital at Westmead, Westmead, Australia.

ba0007p39

Stature and body weight more than age explain functionality level in children with Osteogenesis Imperfecta

Claudio de Castro Luiz De David Ana Coelho Giovana Coccato Livia

University of Brasilia, Brasília, Brazil.

ba0007p40

Increased prevalence of fractures in poorly chelated children with beta thalassemia

Palande Sonal Ekbote Veena Padidela Raja Mughal Zulf Khadilkar Anuradha Khadilkar Vaman Kariki Eleni Crabtree Nicola

¹Hirabai Cowasji Jehangir Medical Research Institute, Pune, India; ²Department of Paediatric Endocrinology, Royal Manchester Children’s Hospital Manchester University NHS Foundation Trust, Oxford Road, Manchester, UK; ³Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Oxford Road, Manchester, UK; ⁴Department of Diabetes and Endocrinology, Birmingham Women’s and Children’s NHS Foundation Trust, Steelhouse Lane, Birmingham, UK.

ba0007p41

FGF 23 measurements in children with fibrous dysplasia: useful or not?

Huma Zilla Mackinnon Natasha Aston Will Pollock Rob

Royal National Orthopaedic Hospital, London, UK.

ba0007p42

Bone health is compromised in adult patients with childhood-onset autoimmune-polyendocrinopathy-candiadis-ectodermal dystrophy (APECED)

Laakso Saila Borchers Joonatan Toiviainen-Salo Sanna Makitie Outi

¹Helsinki University Hospital, Helsinki, Finland; ²University of Helsinki, Helsinki, Finland; ³Folkhälsan Research Center, Helsinki, Finland.

ba0007p43

Bone mass and vertebral fractures in South African (SA) children on prolonged oral glucocorticoids (GCs) for chronic non-malignant illnesses

Thandrayen Kebashni Petersen Karen Kala Udai Lala Nilesh Ambaram Priya Mistry Bhadrish Hauptfleisch Marc Hajinicolaou Christina Okudu Grace Verwey Charl Moosa Fatima Parbhoo Kiran Pettifor John M

Department of Paediatrics, Faculty of Health Sciences, C.H Baragwanath Academic Hospital, University of the Witwatersrand, Johannesburg, South Africa.

ba0007p44

Osteogenesis imperfecta type 15 with neurological phenotype associated with homozygous WNT1 mutation and uniparental isodisomy for chromosome 12

Crowe Belinda Heathfield Mark Edwards Karen Clark Chris Hupin Emilie Bultitude Alex Calder Alistair Lees Melissa Liesner Ri Allgrove Jeremy DeVile Catherine

¹Highly Specialised Osteogenesis Imperfecta Service, The Wolfson Neurodisability Service, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK; ²Department of Paediatric Radiology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK; ³Clinical Genetics Unit, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK; ⁴Haemophilia Comprehensive Care Centre, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.

ba0007p45

Vertebral fractures are more prevalent than long bone fractures in boys with glucocorticoid-treated Duchenne Muscular Dystrophy: Results of a prospective observational study

Jackowski Stefan A McAdam Laura C Ma Jinhui McMillan Hugh J Konji Victor N Matzinger Mary Ann Shenouda Nazih Jaremko Jacob L Koujok Khaldoun Khan Nasrin Khatchadourian Karine Robinson Marie-Eve MacLeay Lynn Saleh David S Siminoski Kerry Rauch Frank Ward Leanne M

¹Children’s Hospital of Eastern Ontario Research Institute, University of Ottawa, Ottawa, Canada; ²Department of Pediatrics, University of Toronto, Toronto, Canada; ³Department of Health Research Methods, Evidence, and Impact McMaster University, Hamilton, Canada; ⁴Department of Pediatrics, University of Ottawa, Ottawa, Canada; ⁵Department of Medical Imaging, University of Ottawa, Ottawa, Canada; ⁶Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, Canada; ⁷Department of Pediatrics, McGill University, Montreal, Canada; ⁸Department of Pediatrics, Queen’s University, Kingston, Canada; ⁹Department of Medicine, University of Alberta, Edmonton, Canada.

ba0007p46

Anorexia nervosa: weighing in on bone health surveillance: When should it be performed?

Ayya Mekhala Crabtree Nicola Shaw Nicholas

Birmingham Chidlrens Hospital, Birmingham, UK.

ba0007p47

Does improved genetic screening make it more difficult to diagnose Osteogenesis Imperfecta?

Burke Eleanor ODonnell Gillian McCarron Laura McDonnell Ciara

¹Temple Street Children’s University Hospital, Dublin, Ireland; ²Discipline of Paediatrics, University of Dublin, Trinity College, Dublin, Ireland.

ba0007p48

Bone mineral density and vitamin D status in children with chronic neurological syndromes - clinical observations

Jakubowska-Pietkiewicz Elzbieta Porczynski Maciej Rychlowska Ewa Albinska Paulina Wozniak Elzbieta Toporowska-Kowalska Ewa

¹Department of Paediatric Propedeutics and Bone Metabolism Diseases, Medical University of Lodz, Lodz, Poland; ²Department of Paediatric Allergology, Gastroenterology and Nutrition, Medical University of Lodz, Lodz, Poland.

ba0007p49

Treatment with asfotase alfa for patients with infantile hypophosphatasia and screening plan of hypophosphatasia by low ALP level and dental findings in Korea

Cho Sungyoon Jin Dong-Kyu

Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

ba0007p50

Higher dose of burosumab is needed for treatment of children with severe forms of X-linked hypophosphatemia

Zhukouskaya Volha V Audrain Christelle Lambert Anne-Sophie Colao Annamaria Kamenicky Peter Adamsbaum Catherine Nevoux Jerome Chaussain Catherine Wicart Philippe Briot Karine Di Rocco Federico Trabado Severine Prie Dominique Rothenbuhler Anya Linglart Agnes

¹APHP, Reference Center for Rare Disorders of the Calcium and Phosphate Metabolism, Filiere OSCAR and Platform of Expertise for Rare Diseases Paris-Sud, Bicêtre Paris-Sud Hospital, Le Kremline Bicetre, France; ²Department of Clinical Medicine and Surgery, Division of Endocrinology, University of Naples Federico II, Naples, Italy; ³Paris Sud – Paris Saclay University, Faculté de Médecine, Le Kremlin- Bicêtre, France; ⁴APHP, Department of Endocrinology and Diabetology for children, Bicêtre Paris Sud Hospital, Le Kremlin- Bicêtre, France; ⁵APHP, Department of Endocrinology and Reproductive Diseases, Bicêtre Paris Sud Hospital, Le Kremlin- Bicêtre, France; ⁶APHP Department of Pediatric Radiology, Bicêtre Paris Sud Hospital, Le Kremlin- Bicêtre, France; ⁷APHP Department of ORL, Bicêtre Paris Sud Hospital, Le Kremlin- Bicêtre, France; ⁸Department of Odontology-Maladies Rares, Hospital Bretonneau, Paris, France; ⁹Université Paris Descartes, Paris, France; ¹⁰Department of Pediatric orthopaedic surgery, Necker - Sick Kids University Hospital, Paris, France; ¹¹APHP, Department of Rheumatology Hospital Cochin, Paris, France; ¹²Pediatric Neurosurgery, Hospital Femme Mere Enfant, Hospices Civiles de Lyon and University Claude Bernard Lyon, Bron Cedex, France; ¹³Reference Center for Craniosynostosis, INSERM 1033, Lyon, France; ¹⁴APHP, Department of Molecular Genetics, Pharmacogenetics and Hormonology, Bice^tre Paris-Sud Hospital, Le Kremlin Bicêtre, France; ¹⁵Université Paris V, Faculté de Médecine, Paris, France; ¹⁶Hôpital Necker Enfants Malades APHP, INSERM U1151, Paris, France.

ba0007p51

Variable familial expression of spondylometaphyseal dysplasia with coxa vara and a novel FN1 mutation

Steichen-Gersdorf Elisabeth Biedermann Rainer Wansch Juergen Witsch-Baumgartner Martina

¹Department of Pediatrics, Innsbruck, Austria; ²Department of Orthopedics, Innsbruck, Austria; ³Department of Orthopedics, Innsbruck, Austria; ⁴Centre of Medical Genetics, Austria.

ba0007p52

Successful treatment with enzyme replacement therapy in a girl with severe infantile Hypophosphatasia

Heldt Katrin L'Allemand Dagmar

Eastern Switzerland Children’s Hospital, St. Gallen, Switzerland.

ba0007p53

Is oral health correlated with skeletal phenotype in primary metabolic bone diseases? A preliminary report of the Greek experience

Doulgeraki Artemis Gatzogianni Margarita Agouropoulos Andreas Athanasopoulou Helen Polyzois Georgios Kavvadia Aikaterini

¹Department of Bone and Mineral Metabolism, Institute of Child Health, Athens, Greece; ²Department of Paediatric Dentistry, National and Kapodistrian University of Athens, Athens, Greece.

ba0007p54

Abstract unavailable

ba0007p55

Unusual cause of abdominal pain in adolescent girl

Kolsky Alexander Libansky Petr Jiskrova Hana Bayer Milan

¹Third Faculty of Medicine, Charles University in Prague, Prague 10, Czech Republic; ²First Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czech Republic; ³First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.

ba0007p56

Effective therapy with growth hormone of an adolescent patient with growth hormone deficiency and osteopetrosis: A case report

Vlachopapadopoulou Elpis Athina Dikaiakou Eirini Samelis Panagiotis Michalacos Stefanos

¹Endocrinology, Growth and Development Department, ‘P. & A. Kyriakou’ Children’s Hospital, Athens, Greece; ²1st Orthopaedic Surgery Department ‘P.&A. Kyriakou’ Children’s Hospital, Athens, Greece.

ba0007p57

The validity of serum alkaline phosphatase to identify nutritional rickets in Nigerian children on a calcium-deprived diet

Thacher Tom Sempos Christopher Durazo-Arvizu Ramon Munns Craig Fischer Philip Pettifor John

¹Mayo Clinic, Rochester, USA; ²Vitamin D Standardization Program LLC, Havre de Grace, USA; ³Loyola University Chicago, Chicago, USA; ⁴The Children’s Hospital at Westmead, Sydney, Australia; ⁵University of the Witwatersrand, Johannesburg, South Africa.

ba0007p58

Effective treatment of a patient with Hypophosphatemic Rickets leading to normal adult height

Vlachopapadopoulou Elpis-Athina Athanasouli Fani Dikaiakou Eirini Samelis Panagiotis Michalacos Stefanos

¹Department of Endocrinology, Growth and Development, ‘P. & A. Kyriakou’ Children’s Hospital, Athens, Greece; ²1st Orthopedic Department, ‘P.&A. Kyriakou’ Children’s Hospital, Greece.

ba0007p59

FGF23-expressing osteocytes are confined to bone packets that completed primary mineralization in patients with chronic kidney disease on dialysis (CKD5D)

Fratzl-Zelman Nadja Pereira Renata C Roschger Paul Salusky Isidro B Klaushofer Klaus Wesseling-Perry Katherine

¹Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGK and AUVA Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital, Vienna, Austria; ²Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, USA.

ba0007p60

Biochemical and genetic analysis in patients with odontohypophosphatasia in Japan

Kubota Takuo Ohata Yasuhisa Ishihara Yasuki Fujiwara Makoto Takeyari Shinji Yamamoto Kenichi Nakano Yukako Miyata Kei Nakayama Hirofumi Kitaoka Taichi Okawa Rena Nakano Kazuhiko Akiyama Tomoyuki Ozono Keiichi

¹Osaka University, Suita, Japan; ²Okayama University, Okayama, Japan.

ba0007p61

Tissue non-specific alkaline phosphatase activity and mineralization capacity of bi-allelic mutations from severe perinatal and asymptomatic hypophosphatasia phenotypes: Results from an in-vitro mutagenesis model

Uday Suma Matsumara Tomohiro Saraff Vrinda Saito Shiho Orimo Hideo Hogler Wolfgang

¹Department of Endocrinology and Diabetes, Birmingham Women’s and Children’s Hospital, Birmingham, UK; ²Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK; ³Department of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo, Japan; ⁴Department of Paediatrics and Adolescent Medicine, Johannes Kepler University, Linz, Austria.

ba0007p62

Bone geometry and microarchitecture deficits in children with Alagille syndrome

Kindler Joseph Mitchell Ellen Piccoli David Grimberg Adda Leonard Mary Loomes Kathleen Zemel Babette

¹The Children’s Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; ²St Christopher’s Hospital for Children and Department of Pediatrics at Drexel University School of Medicine, Philadelphia, PA, USA; ³Stanford School of Medicine, Palo Alto, CA, USA.

ba0007p63

Missense mutations in ENPP1 result in osteoporosis in patients and is recapitulated in the ENPP1 loss of function murine model

Braddock Demetrios Oheim Ralf Zimmerman Kristin Kavanagh Dillon Horowitz Mark Carpenter Thomas

¹Department of Pathology, Yale University Medical School, New Haven, CT, USA; ²Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; ³Department of Orthopædics and Rehabilitation, Yale University School of Medicine, New Haven, CT, USA; ⁴Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA.

ba0007p64

Tumor induced osteomalacia in a 12-year-old girl: Case report

Phatarakijnirund Voraluck Veerapan Puwadon Chotipanich Chanisa Numbenjapon Nawaporn Kongkarnka Chawkaew

¹Department of Pediatrics, Phramongkutklao Hospital and College of Medicine, Bangkok, Thailand; ²Department of Orthopedics, Phramongkutklao Hospital and College of Medicine, Bangkok, Thailand; ³National Cyclotron and PET Centre, Chulabhorn Hospital, Bangkok, Thailand; ⁴Queen Sirikit National Institute of Child Health, Bangkok, Thailand.

ba0007p65

Bone densitometry and body composition in children with hypophosphatasia

Mciver William Whittaker Lucy Crabtree Nicola Hogler Wolfgang Saraff Vrinda

¹Department of Endocrinology and Diabetes, Birmingham Women’s and Children’s Hospital, Birmingham, UK; ²Department of Paediatrics and Adolescent Medicine, Johannes Kepler University, Linz, Austria.

ba0007p66

Bone health outcomes in children and adolescents with neuromuscular disease

Biggin Andrew Chua Verene Wall Christie Pacey Verity Gray Kelly McGee Richard Poon Myra Munns Craig

¹The Children’s Hospital at Westmead, Westmead, Australia; ²The University of Sydney Children’s Hospital Westmead Clinical School, Sydney, Australia; ³Macquarie University, North Ryde, Australia.

ba0007p67

Clinical case of a child with a hereditary vitamin D dependent rickets type 1a, complicated by rachitic lung and oxygen dependence

Polyakova Nina Kakaulina Victoria Zarubina Vera Nagornova Tatiana Petraykina Elena Pechatnikova Natalia

¹Morozov Children’s Municipal Clinical Hospital of the Moscow City Health Department, Moscow, Russian Federation; ²FSBI Research Center for Medical Genetic, Moscow, Russian Federation.

ba0007p68

Experience of implementation and monitoring of burosumab treatment in a multi-disciplinary setting

Marr Caroline Greenacre Gemma Arundel Paul

Sheffield Children’s NHS Foundation Trust, Sheffield, UK.

ba0007p69

Metabolic bone disease of prematurity - comparing neonatal and endocrine approaches using a nationwide survey

Chinoy Amish Mughal Zulf Padidela Raja

Royal Manchester Children’s Hospital, Manchester, UK.

ba0007p70

Necessity of high dose and prolonged duration denosumab post stem cell transplant for TNFRSF11A osteoclast-poor autosomal recessive osteopetrosis

Taylor-Miller Tashunka Doss Hemalatha Weerdenburg Heather Whiting Sam Sivaprakasam Ponni Gassass Adam Smithson Sarah F Steward Colin G Burren Christine P

¹Department of Paediatric Endocrinology, Bristol Royal Hospital for Children, University Hospitals Bristol NHS Foundation Trust Bristol, Bristol, UK; ²Department of Blood and Marrow Transplantation, Bristol Royal Hospital for Children, University Hospitals Bristol NHS Foundation Trust Bristol, Bristol, UK; ³Department of Pharmacy, Bristol Royal Hospital for Children, University Hospitals Bristol NHS Foundation Trust Bristol, Bristol, UK; ⁴Department of Clinical Genetics, St Michaels Hospital, University Hospitals Bristol NHS Foundation Trust Bristol, Bristol, UK; ⁵Bristol Medical School: Translational Health Sciences, University of Bristol, Bristol, UK.

ba0007p71

Burosumab experience in UK X-linked hypophosphataemia children under five years old

Dharmaraj Poonam Burren Christine Cheung Moira S Padidela Raja Mughal Zulf Shaw Nick Saraff Vrinda Nadar Ruchi Randell Tabitha Mushtaq Talat Ramakrishnan Renuka Sennipathan Senthil Sakka Sophia Bath Louise Elleri Daniela Davies Justin H Barton John Tucker Ian Rayner Lauren Arundel Paul Gilbey-Cross Robyn Tothill Alexander M Philip James Sawoky Nadine Connor Paul Mathieson Leigh

¹Alder Hey Children’s Hospital, Liverpool, UK; ²Bristol Royal Hospital for Children, Bristol, UK; ³Evelina Children’s Hospital, London, UK; ⁴Royal Manchester Children’s Hospital, Manchester, UK; ⁵Birmingham Children’s Hospital, Birmingham, UK; ⁶Nottingham Children’s Hospital, Nottingham, UK; ⁷Leeds Teaching Hospital, Leeds, UK; ⁸Royal Hospital for Sick Children, Edinburgh, UK; ⁹Southampton University Hospital, Southampton, UK; ¹⁰Sheffield Children’s Foundation Trust, Sheffield, UK; ¹¹MAP BioPharma, Papworth Everard, Cambridge, UK; ¹²Kyowa Kirin, Galashiels, UK.

ba0007p72

Burosumab initiation in a UK X-linked hypophosphataemia cohort: real-world use resonates with research evidence

Dharmaraj Poonam Burren Christine Cheung Moira S Padidela Raja Mughal Zulf Shaw Nick Saraff Vrinda Nadar Ruchi Randell Tabitha Mushtaq Talat Ramakrishnan Renuka Sennipathan Senthil Sakka Sophia Bath Louise Elleri Daniela Davies Justin H Barton John Tucker Ian Rayner Lauren Arundel Paul Gilbey-Cross Robyn Tothill Alexander M Philip James Sawoky Nadine Connor Paul Mathieson Leigh

¹Alder Hey Children’s Hospital, Liverpool, UK; ²Bristol Royal Hospital for Children, Bristol, UK; ³Evelina Children’s Hospital, London, UK; ⁴Royal Manchester Children’s Hospital, Manchester, UK; ⁵Birmingham Children’s Hospital, Birmingham, UK; ⁶Nottingham Children’s Hospital, Nottingham, UK; ⁷Leeds Teaching Hospital, Nottingham, UK; ⁸Royal Hospital for Sick Children, Edinburgh, UK; ⁹Southampton University Hospital, Southampton, UK; ¹⁰Sheffield Children’s Foundation Trust, Sheffield, UK; ¹¹MAP BioPharma, Papworth Everard, Cambridge, UK; ¹²Kyowa Kirin, Galashiels, UK.

ba0007p73

Burosumab can improve pain and quality of life for children with X-linked hypophosphataemia and their families: a London centre's experience

Gilbey-Cross Robyn Sandy Jessica L Morris Mavali Cocca Alessandra Sakka Sophia D Massey Jill Cheung Moira S

Evelina London Children’s Hospital, London, UK.

ba0007p74

Active vitamin D analogues and oral phosphate for the treatment of X-linked hypophosphataemia in paediatric patients: A systematic literature review and survey of expert opinion on current needs

Ariceta Gema Collantes Carmen de Lucas Jandhyala Ravi Mughal Zulf

¹Hospital Universitario Materno-Infantil Vall d’Hebron, Universitat Autonoma de Barcelona, Barcelona, UK; ²Hospital Niño Jesús, Madrid, Spain; ³Medialis, Banbury, UK;⁴Royal Manchester Children’s Hospital, Manchester, UK.

ba0007p75

Safety profile of asfotase alfa treatment of patients with hypophosphatasia: a pooled analysis

Whyte Michael P Bishop Nick Hasan Jawad Hofmann Christine Hogler Wolfgang Rockman-Greenberg Cheryl Sena Veruska Zhou Shanggen Kishnani Priya S

¹Center for Metabolic Bone Disease and Molecular Research, Shriners Hospital for Children, Saint Louis, USA; ²Department of Oncology and Metabolism, University of Sheffield and Sheffield Children’s NHS FT, Sheffield, UK; ³Alexion Pharmaceuticals, Inc., Boston, USA; ⁴University Children’s Hospital, University of Würzburg, Würzburg, Germany; ⁵Department of Pediatrics and Adolescent Medicine, Johannes Kepler University Linz, Linz, Austria; ⁶University of Manitoba, Rady Faculty of Health Sciences, Max Rady College of Medicine, and Children’s Hospital Research Institute of Manitoba, Winnipeg, Canada; ⁷Covance, Inc., Princeton, USA; ⁸Department of Pediatrics, Duke University Medical Center, Durham, USA.

ba0007p76

Long-term efficacy profile of asfotase alfa in the treatment of patients with hypophosphatasia: a pooled analysis

Hogler Wolfgang Rockman-Greenberg Cheryl Petryk Anna Zhou Shanggen Whyte Michael P Bishop Nick

¹University of Sheffield, Sheffield, UK; ²Department of Pediatrics and Adolescent Medicine, Johannes Kepler University Linz, Linz, Austria; ³University of Manitoba, Rady Faculty of Health Sciences, Max Rady College of Medicine, and Children’s Hospital Research Institute of Manitoba, Winnipeg, Canada; ⁴Alexion Pharmaceuticals, Inc., Boston, USA; ⁵Covance, Inc., Princeton, USA; ⁶Center for Metabolic Bone Disease and Molecular Research, Shriners Hospital for Children-St.Louis, Saint Louis, USA.

ba0007p77

Abstract unavailable

ba0007p78

Novel imaging approaches to the quantification of musculoskeletal alterations in X-linked hypophosphatemic rickets (XLH)

Raimann Adalbert Mehany Sarah N Feil Patricia Weber Michael Boni-Mikats Andrea Klepochova Radka Krssak Martin Pietschmann Peter Haeusler Gabriele Schneider Johannes Raum Kay Patsch Janina

¹University Department of Pediatric and Adolescent Medicine, Division of Pediatric Pulmonology, Allergology and Endocrinology, Medical University of Vienna, Vienna, Austria; ²University Department of Biomedical Imaging and Image-guided Therapy, Division of General and Paediatric Radiology, Vienna, Austria; ³University Department of Surgery, Division of Pediatric Surgery, Medical University of Vienna, Vienna, Austria; ⁴University Department of Biomedical Imaging and Image-guided Therapy, The High Field MR Centre, Vienna, Austria; ⁵University Department of Medicine III, Division of Endocrinology and Metabolism, Medical University of Vienna, Vienna, Austria; ⁶Berlin-Brandenburg Center for Regenerative Therapies, Charité - Universitätsmedizin Berlin, Berlin, Germany; ⁷Institute of Pathophysiology and Allergy Research, Center of Physiology and Pathophysiology, Medical University of Vienna, Vienna, Austria.

ba0007p79

Characterization of pain in patients with fibrous dysplasia

Spencer Tiahna Javaid Kassim Boyce Alison

¹Skeletal Disorders and Mineral Homeostasis Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, USA; ²Botnar Research Centre, Nuffield Department of Orthopaedics, NDORMS, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.

ba0007p80

Bone health in adolescent females with anorexia nervosa may be preserved by high lean mass

Nour Munier Baril Chantelle Kontulainen Saija Kurji Ayisha Baxter-Jones Adam Erlandson Marta

University of Saskatchewan, Saskatoon, Canada.

ba0007p81

Tertiary hyperparathyroidism and post-operative hungry bone syndrome in a patient with X-linked hypophosphatemic rickets

Nour Munier Inman Mark

University of Saskatchewan, Saskatoon, Canada.

ba0007p82

Could digital X-ray radiogrammetry be an alternative for dual energy X-ray absorptiometry

Leijten Alex Hampsink Brieke Janssen Marcel Klein Willemijn Draaisma Jos

¹Radboudumc Amalia Children’s Hospital, department of General Paediatrics, Nijmegen, Netherlands; ²Radboudumc, Department of Radiology and Nuclear Medicine, Nijmegen, Netherlands.

ba0007p83

Abstract unavailable

ba0007p84

Neonatal calcinosis cutis due to a mutation in the GNAS gene

Levy-Shraga Yael Barel Ortal Javasky Elisheva Barzilai Aviv Greenberger Shoshana

¹Pediatric Endocrinology and Diabetes Unit, The Edmond and Lily Safra Children’s Hospital, Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel; ²The Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel; ³The Genomic Unit, Sheba Cancer Research Center, Tel Hashomer, Ramat-Gan, Israel; ⁴Pediatric Dermatology service, The Department of Dermatology, Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel.

ba0007p85

Disease-specific pathological traits of youth at risk of secondary osteoporosis as determined through peripheral Quantitative Computed Tomography

Chivers Paola Jenkins Mark Hart Nicolas Rantalainen Timo McIntyre Fleur Hands Beth Nimphius Sophia Rothacker Karen Beck Belinda Weeks Benjamin Beeson Brendan Siafarikas Aris

¹The University of Notre Dame Australia/Institute for Health Research, Fremantle, Australia; ²Edith Cowan University, Joondalup, Australia; ³University of Jyvaskyla, Jyvaskyla, Finland; ⁴Perth Children’s Hospital, Nedlands, Australia; ⁵Griffith University, Brisbane, Australia.

ba0007p86

Assessment of bone density by DXA in poorly controlled children with β-Thalassemia: Correction for hepatic iron - overloadby manual analysis

Palande Sonal Ekbote Veena Padidela Raja Mughal Zulf Khadilkar Anuradha Khadilkar Vaman Crabtree Nicola

¹Hirabai Cowasji Jehangir Medical Research Institute, Pune, India; ²Department of Paediatric Endocrinology, Royal Manchester Children’s Hospital Manchester University NHS Foundation Trust, Manchester, UK; ³Department of Diabetes and Endocrinology, Birmingham Women’s and Children’s NHS Foundation Trust, Birmingham, UK.

ba0007p87

Diagnostic performance of morphometric vertebral fracture analysis (MXA) in children using a 33-point software programme

Alqahtani Fawaz Crabtree Nicola Bromiley Paul Cootes Timothy Broadley Penny Lang Isla Offiah Amaka C

¹Academic Unit of Child Health, University of Sheffield, Sheffield, UK; ²Department of Radiological Sciences, College of Applied Medical Sciences, Najran University, Najran, Kingdom of Saudi Arabia; ³Department of Endocrinology and Diabetes, Birmingham Women’s and Children’s NHS Foundation Trust, Birmingham, UK; ⁴Imaging Sciences Research Group, University of Manchester, Manchester, UK; ⁵Radiology Department, Sheffield Children’s NHS Foundation Trust, Sheffield, UK.

ba0007p88

Use of DXA and pQCT measurements to screen for fracture risk in 3 to 18 year old poorly chelated thalassaemic children

Palande Sonal Ekbote Veena Chilplonkar Shashi Chauthmal Sujata Khadilkar Vaman Ramanan Vijay Khadilkar Anuradha Padidela Raja Mughal Zulf Crabtree Nicola

¹Hirabai Cowasji Jehangir Medical Research Institute, Pune, India; ²Yashoda Hematology Clinic, Pune, Pune; ³Department of Paediatric Endocrinology, Royal Manchester Children’s Hospital Manchester University NHS Foundation Trust, Mancheste, UK; ⁴Department of Diabetes and Endocrinology, Birmingham Women’s and Children’s NHS Foundation Trust, UK.

ba0007p89

Osteogenesis imperfecta due to FKBP10 mutation- shift from high to low bone turnover

Lenherr-Taube Nina Harrington Jennifer Murphy Anne Filipowski Kornelia Kin On Wong Andy Horward Andrew Sochett Etienne

¹Department of Pediatrics, Division of Endocrinology, Hospital for Sick Children, University of Toronto, Toronto, Canada; ²Department of Pediatric Surgery, Division of Orthopaedics, Hospital for Sick Children, University of Toronto, Toronto, Canada; ³Joint Department of Medical Imaging, Toronto General Research Institute, University Health Network; Department of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.

ba0007p90

Bone health index by hand X-ray compared with bone mineral density by dual-energy X-ray absorptiometry in children with Duchenne muscular dystrophy

Bowden Jonathan J Krishnamurthy Ramkumar Hu Houchun Adler Brent Krishnamurthy Rajesh Bowden Sasigarn A

¹Department of Radiology, Nationwide Children’s Hospital, Columbus, USA; ²Department of Endocrinology, Nationwide Children’s Hospital, Columbus, USA.

ba0007p91

A little girl with bowing of legs, a short mother and a waddling sister: Metaphyseal Chondrodysplasia, Schmid type

Nimali Seneviratne Sumudu Wanniarachchige Harshika Thilakarathna Kanishka Samarasinghe Nayana

¹Faculty of Medicine, University of Colombo, Colombo, Sri Lanka; ²Lady Ridgeway Hospital for Children, Colombo, Sri Lanka.

ba0007p92

Assessing the ability of vibration analysis to differentiate wrist and ankle fractures from sprains in children

Fennimore David Ali Ridita Alboul Lyuba Offiah Amaka

¹University of Sheffield, Sheffield, UK; ²Sheffield Hallam University, Sheffield, UK.

ba0007p93

Characteristics of ultradistal radius bone density during childhood: results from the Bone Mineral Density in Childhood Study

Kindler Joseph Mitchell Jonathan McCormack Shana Cousminer Diana Chesi Alessandra Kelly Andrea Lappe Joan Gilsanz Vicente Oberfield Sharon Shepherd John Winer Karen Kalkwarf Heidi Grant Struan Zemel Babette

¹The Children’s Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA; ²Creighton University, Omaha, Nebraska, USA; ³Children’s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California, USA; ⁴Columbia University, New York, New York, USA; ⁵University of Hawaii, Honolulu, Hawaii, USA; ⁶National Institutes of Health, National Institute of Child Health and Human Development, Bethesda, Maryland, USA; ⁷Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.

ba0007p94

Detection of intact FGF23 using a novel well-characterized ELISA

Wallwitz Jacqueline Gadermaier Elisabeth Bitzer Annegret Himmler Gottfried

¹The Antibody Lab GmbH, Vienna, Austria; ²Biomedica Medizinprodukte GmbH, Vienna, Austria.

ba0007p95

Radiofrequency echographic multispectrometry (REMS): a new approach for osteoporosis diagnosis in adolescents

Caffarelli Carla Pitinca Maria Dea Tomai Nuti Ranuccio Gonnelli Stefano

¹Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy; ²National Council of Research, Institute of Clinical Physiology, Lecce, Italy.

ba0007p96

Association of serum alkaline phosphatase with radiological rickets severity in children with X-linked hypophosphataemia on conventional therapy

Uday Suma Shaw NJ Mughal ZM Randell Tabitha Hogler Wolfgang Santos Rui Padidela Raja

¹Department of Diabetes and Endocrinology, Birmingham Women’s and Children’s Hospital, Birmingham, UK; ²Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK; ³Department of Paediatric Endocrinology, Royal Manchester Children’s Hospital, Manchester, UK; ⁴Department of Paediatric Endocrinology and Diabetes, Nottingham University Hospital, Nottingham, UK; ⁵Department of Paediatric and Adolescent Medicine, Johannes Kepler University, Linz, Austria; ⁶Department of Radiology, Evelina London Children’s Hospital, London, UK.

ba0007p97

The effect of vitamin D on bone health assessed by radiogrammetry: a double-blind placebo-controlled vitamin D supplementation trial in infants

Uday Suma Crowe Francesca Bowie Jessica Mughal Zulf Manaseki-Holland Semira Hogler Wolfgang

¹Department of Diabetes and Endocrinology, Birmingham Women’s and Children’s Hospital, Birmingham, UK; ²Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK; ³Institute of Applied Health Research, University of Birmingham, Birmingham, UK; ⁴College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK; ⁵Department of Paediatric Endocrinology, Manchester Children’s Hospital, Manchester, UK; ⁶Department of Paediatrics and Adolescent Medicine, Johannes Kepler University, Linz, Austria.

ba0007p98

Pre and post-natal achondroplasia, retrospective series of 64 consecutives cases with analyze of the diagnostic methods and timing issues

Baujat Genevieve Borghese Roxana Sonigo Pascale Bacrot Severine Bengoa Joana Michot Caroline Millischer Anne-Elodie Rondeau Sophie Childs Beatrice Attie-Bittach Tania Bessieres Bettina Salomon Laurent Ville Yves Bonnefont Jean-Paul Steffann Julie Cormier-Daire Valerie

¹Department of Medical Genetics, Centre of Reference for Skeletal Dysplasia, Necker-Enfants Malades Hospital (AP-HP), Institut IMAGINE, University Paris Descartes, Paris, France; ²Department of Molecular Genetics, Necker-Enfants Malades Hospital (AP-HP), University Paris Descartes, Paris, France; ³Department of Radiology, Necker-Enfants Malades Hospital (AP-HP), University Paris Descartes, Paris, France; ⁴Department of Foetopathology, Necker-Enfants Malades Hospital (AP-HP), University Paris Descartes, Paris, France; ⁵Department of Obstetrics, Necker-Enfants Malades Hospital (AP-HP), University Paris Descartes, Paris, France.

ba0007p99

High-resolution MRI assessment of the muscle-fat-bone unit in young adults with childhood onset Crohn's disease

Steell Lewis Johnston Blair Ahmed S Faisal Gaya Daniel R MacDonald Jonathan Seenan John Paul Russell Richard K Gray Stuart Wong Jarod

¹Institute of Cardiovascular and Medical Science, University of Glasgow, Glasgow, UK; ²Developmental Endocrinology Research Group, University of Glasgow, Glasgow, UK; ³MRI Physics, Department of Physics & Bioengineering, NHS Greater Glasgow & Clyde, Glasgow, UK; ⁴Department of Gastroenterology, NHS Greater Glasgow & Clyde, Glasgow, UK; ⁵Department of Paediatric Gastroenterology, The Royal Hospital for Children, Glasgow, UK.

ba0007p100

Vitamin D levels among Lebnaese children: Do we need to alter normal level?

El Ali Margo Yaghi Yasser

¹Beirut Arab University, Saida, Lebanon; ²Ain WaZein Medical Village, Ain WaZein, Lebanon.

ba0007p101

Vitamin D deficiency in children in Israel: A cross-sectional study and possible associated factors

Korchia Gerard Korchia Martine

Meuhedet Health Services, Jerusalem, Israel.

ba0007p102

Abstract unavailable

ba0007p103

Vitamin D deficiency nutritional rickets presenting to secondary care in children (<16 Years) - A United Kingdom surveillance study

Shaw Nick Mughal Zulf Julies Priscilla Pall Karina Lynn Richard Leoni Marina Calder Alistair McDonnell Ciara McDevitt Helen Blair Mitch

¹Birmingham Children’s Hospital, Birmingham, UK; ²Royal Manchester Children’s Hospital, Manchester, UK; ³Royal Free London NHS Foundation Trust, London, UK; ⁴Royal College of Paediatrics & Child Health, London, UK; ⁵Great Ormond Street Hospital, London, UK; ⁶Temple Street Children’s Hospital, Dublin, Ireland; ⁷Royal Hospital for Sick Children, Glasgow, UK; ⁸Northwick Park Hospital, London, UK.

ba0007p104

Respiratory health impacts quality of life for adults with OI

Yonko Elizabeth Carter Erin Sandhaus Robert Raggio Cathleen

¹Hospital for Special Surgery, New York, USA; ²Alphanet; National Jewish Health, Littleton, USA.

ba0007p105

Scoliosis and cardiopulmonary outcomes in adults with osteogenesis imperfecta: a pilot study

Khan Sobiah Yonko Elizabeth Carter Erin Sandhaus Robert Raggio Cathleen

¹Hospital for Special Surgery, New York, USA; ²Alphanet; National Jewish Health, Littleton, USA.

ba0007p106

Sex differences in the longitudinal associations between body composition and bone stiffness index in European children and adolescents

Cheng Lan Pohlabeln Hermann Ahrens Wolfgang Russo Paola Veidebaum Toomas Chadjigeorgiou Charalambos Molnar Denes Eiben Gabriele De Henauw Stefaan Moreno Luis Page Angie Hebestreit Antje

¹Leibniz Institute for Prevention Research and Epidemiology–BIPS, Bremen, Germany; ²Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany; ³Institute of Food Sciences, National Research Council, Avellino, Italy; ⁴Department of Chronic Diseases, National Institute for Health Development, Tallinn, Estonia; ⁵Research and Education Institute of Child Health, Strovolos, Cyprus; ⁶National Institute of Health Promotion, University of PeÂcs, PeÂcs, Hungary; ⁷Section for Epidemiology and Social Medicine (EPSO), Department of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; ⁸Department of Public Health, Ghent University, Ghent, Belgium; ⁹GENUD (Growth, Exercise, Nutrition and Development) Research Group, Instituto Agroalimentario de Aragón (IA2), Instituto de Investigación Sanitaria Aragón (IIS Aragón), Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBERObn), University of Zaragoza, Zaragoza, Spain; ¹⁰Centre for Exercise, Nutrition & Health Sciences, University of Bristol, Bristol, UK.

ba0007p107

Abstract unavailable

ba0007p108

Fracture prevalence in children 0-19 years-old in Mexico: A 10-year cross-sectional analysis

Clark Patricia Barbato Annarella Guagnelli Miguel Angel Rascon Jose Alberto Denova Edgar Borja Victor Hugo

¹Hospital Infantil de Mexico Federico Gomez, Mexico; ²Instituto Mexicano del Seguro Social, Mexico; ³Universidad Nacional Autónoma de México, Mexico; ⁴Instituto Nacional de Salud Pública, Mexico.

ba0007p109

Cost-effectiveness of a Vitamin D supplementation programme in pregnant women and children to prevent rickets in the UK

Floreskul Vilius Juma Fatima Daniel Anjali Zamir Imran Mughal Zulf Padidela Raja

¹Royal Manchester University Hospital, Manchester, UK; ²North Manchester General Hospital, Manchester, UK; ³Dolon Ltd, London, UK.

ba0007p110

Vitamin D dependent rickets type 1 caused by CYP27B1 mutation

Kim Chan Jong

Chonnam Natl. Univ. Hospital, Gwangju, South Korea.

ba0007p111

Case report: investigation of an osteolytic lesion leading to the diagnosis of congenital generalized lipodystrophy due to a novel AGPAT2 mutation

Brener Avivit Elkon-Tamir Erella Zeitlin Leonid Lebenthal Yael

¹Pediatric Endocrinology and Diabetes Unit, Dana-Dwek Children’s Hospital, Tel Aviv, Israel; ²Pediatric Orthopedic Department, Dana-Dwek Children’s Hospital, Tel Aviv, Israel; ³Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

ba0007p112

Next-generation sequence and biomarker levels in the patients with early-onset chronic non-bacterial osteomyelitis from North Caucasian region of Russia

Kostik Mikhail Makhova Maria Suspitsin Evgeny Sokolenko Anna Zorin Vyacheslav Isupova Eugenia Magomedova Shamai Kostik Inna Takayanagi Hiroshi Mushkin Alexander Imyanitov Evgeny

¹Saint-Petersburg State Pediatric Medical University, Saint-Petersburg, Saint-Petersburg, Russian Federation; ²N.N. Petrov Institute of Oncology, Saint-Petersburg, Russia; ³Science research Institute of Phthisiopulmonology, Saint-Petersburg, Russia; ⁴Republican Children’s Clinical Hospital, Makhachkala, Russia; ⁵Dagestan State Medical Academy, Makhachkala, Russia; ⁶Children’s Rehabilitation Center Detskye Duny, Saint-Petersburg, Russia; ⁷The University of Tokyo, Tokyo, Japan.

ba0007p113

Hypophosphatasia in Japan: ALPL mutation analysis in 98 patients

Michigami Toshimi Tachikawa Kanako Yamazaki Miwa Kawai Masanobu Kubota Takuo Ozono Keiichi

¹Department of Bone and Mineral Research, Osaka Women’s and Children’s Hospital, Izumi, Japan; ²Department of Pediatrics, Osaka University Graduate School of Medicine, Izumi, Japan.

ba0007p114

Mabry Syndrome is a cause of hyperphosphatasia and mental retardation

Tseretopoulou Xanthippi Mughal Zulf Mushtaq Talat

¹Leeds Teaching Hospitals NHS Trust, Leeds, UK; ²Department of Paediatric Endocrinology, Royal Manchester Childrens’ Hospital, Manchester, UK.

ba0007p115

Molecular genetic diagnosis and genotype-phenotype correlations in children and adolescents with recurrent fractures

Del Gigante Jessica Munns Craig Biggin Andrew

The University of Sydney Children’s Hospital Westmead Clinical School, Westmead, Australia.

ba0007p116

Use of Lego® to explain genetic variations in type 1 collagen - a pilot study

Allgrove Jeremy Heathfield Mark Edwards Karen Clark Chris Hupin Emilie Riddington Megan Bultitude Alex Crowe Belinda DeVile Catherine

¹Great Ormond Street Hospital for Children, Consultant, London, UK; ²Great Ormond Street Hospital for Children, Clinical Nurse Specialist, London, UK; ³Great Ormond Street Hospital for Children, Physiotherapist, London, UK; ⁴Great Ormond Street Hospital for Children, Occupational Therapist, London, UK; ⁵Great Ormond Street Hospital for Children, Clinical Psychologist, London, UK.

ba0007p117

Methyl-CpG-binding protein 2 (MECP2) mutation type is associated with bone disease severity in Rett syndrome

Caffarelli Carla Dea Tomai Pitinca Maria Francolini Valentina Canitano Roberto De felice Claudio Hayek Joussef Gonnelli Stefano

¹Department of Medicine, Surgery and Neuroscience, of Siena, Siena, Italy; ²Paediatrics Neuropsychiatry Unit, Azienda Ospedaliera Universitaria Senese, Siena, Italy.

ba0007p118

A novel mutation in FAM111A gene in child with Kenny-Caffey syndrome type 2 presenting with short statue, medullary stenosis and hypoparathyroidism

Srilanchakon Khomsak Supornsilchai Vichit Suphapeetiporn Kanya

¹Endocrine Unit/Department of Pediatrics/King Chulalongkorn Memorial Hospital, Bangkok, Thailand; ²Excellent Centre of Genetic/Department of Pediatrics/King Chulalongkorn Memorial Hospital, Bangkok, Thailand.

ba0007p119

Mutational and phenotypic spectra in 137 Russian patients with inherited forms of rickets

Kulikova Kristina Kolodkina Anna Vasiliev Evgeny Petrov Vasiliy Tiulpakov Anatoly

Endocrinology Research Centre, Moscow, Russian Federation.

ba0007p120

An Acvr1[R258G] ‘conditional on' mouse model of atypical fibrodysplasia ossificans progressiva (FOP) is Activin A dependent

Huang Lily Schoenherr Chris Wang Lili Wen Xialing McClain Joyce Zhang Qian Nannuru Kalyan Idone Vincent Murphy Andrew Economides Aris Hatsell Sarah

Regeneron Pharmaceuticals, Tarrytown, USA.

ba0007p121

Congenital hyperinsulinism of infancy in a child with autosomal dominant hypocalcaemia type 1 due to an activating calcium sensing receptor mutation

Sastre Ana Shah Pratik Gevers Evelien

¹Royal London Hospital. Barts Health NHS Trust, London, UK; ²Great Ormond Street Hospital, London, UK; ³Centre for Endocrinology, Queen Mary University, London, UK.

ba0007p122

Odontochondrodysplasia in association with a TRIP11 mutation

Sheridan Sabrina McCarron Laura Donnell Gillian O McDonnell Ciara

¹Department of Paediatric Endocrinology, Temple Street Children’s University Hospital, Dublin, Ireland; ²Discipline of Paediatrics, University of Dublin, Trinity College, Dublin, Ireland.

ba0007p123

Heterozygous CDC73 mutation causing parathyroid adenoma in an adolescent girl presenting with mental health issues

Mulvey Ian Ramakrishnan Renuka Dharmaraj Poonam Abernethy Laurence Jones Matthew Senniappan Senthil

Alder Hey Children’s Hospital, Liverpool, UK.

ba0007p124

SCN8a mutations and osteoporosis. Is osteocyte dysfunction the cause or the consequence?

O'Donnell Gillian Halpenny Leah Burke Eleanor McCarron Laura Sheridan Sabrina McDonnell Ciara

¹Department of Paediatric Endocrinology, Temple Street Children’s University Hospital, Dublin, Ireland; ²Discipline of Paediatrics, University of Dublin, Trinity College, Dublin, Ireland; ³Department of Paediatric Neurology, Temple Street Children’s University Hospital, Dublin, Ireland.

ba0007p125

Anemia - novel clinically significant finding during intravenous pamidronate therapy of children diagnosed with osteogenesis imperfecta

Michalus Izabela Nowicka Zuzanna Pietras Wiktoria Nowicka Maja Byrwa Agnieszka Albińska Paulina Jakubowska-Pietkiewicz Elzbieta

¹Medical University of Lodz, Department of Pediatric Propedeutics and Bone Metabolic Diseases, Lodz, Poland; ²Department of Biostatistics and Translational Medicine, Medical University of Lodz, Lodz, Poland; ³Students’ Scientific Association in the Department of Pediatric Propedeutics and Bone Metabolic Diseases, Lodz, Poland.

ba0007p126

Burosumab therapy in pediatric patients with X-linked hypophosphatemia improves body composition

Brener Avivit Cleper Roxana Lebenthal Yael Zeitlin Leonid

¹Pediatric Endocrinology and Diabetes Unit, Dana-Dwek Children’s Hospital, Tel Aviv, Israel; ²Pediatric Nephrology Unit, Dana-Dwek Children’s Hospital, Tel Aviv, Israel; ³Pediatric Orthopedic Department, Dana-Dwek Children’s Hospital, Tel Aviv, Israel; ⁴Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

ba0007p127

Growth hormone effect on bone mineral density in a girl with osteogenesis imperfecta - a case presentation

Leka Sofia Athanasouli Fani Vlachopapadopoulou Elpis Doulgeraki Artemis Petrou Vassilios Fotinou Aspasia Michalacos Stefanos

¹Department of Endocrinology-Growth and Development, ‘P&A Kyriakou’ Children’s Hospital, Athens, Greece; ²Department of Bone and Mineral Metabolism, Institute of Child Health, Athens, Greece; ³Division of Biochemistry-Hormonology, ‘P&A Kyriakou’ Children’s Hospital, Athens, Greece.

ba0007p128

A smartphone-based survey of frequency and severity of adverse effects following bisphosphonate therapy in a Tertiary Paediatric Centre

Blackburn James Price Victoria Ramakrishnan Renuka Dharmaraj Poonam

Alder Hey Children’s Hospital, Liverpool, UK.

ba0007p129

Off label uses of pamidronate in rare pediatric bone diseases (Jansen's Metaphyseal Chondrodysplasia and Generalized Arterial Calcification of Infancy): A four year perspective

Young Kyleen Langman Craig Jueppner Harald

¹Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, USA; ²Feinberg School of Medicine, Chicago, USA; ³MassGeneral Hospital for Children, Boston, USA.

ba0007p130

Use of intravenous pamidronate in pediatric acute lymphoblastic leukemia patients with osteonecrosis (ON) results in reduced pain and improved radiologic outcome of ON lesions: Long- term follow-up over 15-years

Miettunen Paivi Moorani Vijay Haider Seemab Stephenson Seamus Stephenson Chloe Anderson Ronald

ACH and University of Calgary, Calgary, Canada.

ba0007p131

A prospective study of 17 consecutive pediatric patients with chronic non-bacterial osteomyelitis treated with intravenous pamidronate over a 15 year period at a single center reveals excellent clinical and radiologic outcome initially and after flare

Miettunen Paivi Stephenson Chloe Stephenson Seamus Wei Xing-Chang

ACH and University of Calgary, Calgary, Canada.

ba0007p132

Losartan reduces circulating TGFb and CTX and increases vertebral bone mass in the OIM mouse

Bishop Nick Kalajzic Ivo Arshad Fawaz Lefley Diane Gossiel Fatma Ottewell Penny

¹University of Sheffield, Sheffield, UK; ²Sheffield Children’s NHS FT, Sheffield, UK; ³Reconstructive Sciences, University of Connecticut Health Centre, Farmington, CT, USA.

ba0007p133

First report of skin reaction with Zoledronic Acid

Olivier Patricia Fiscaletti Melissa Desroches Anne Alos Nathalie

CHU Sainte-Justine – University of Montreal, Montreal, Canada.

ba0007p134

Oral ibandronate therapy in patients with osteogenesis imperfecta

Kutilek Stepan Skalova Sylva Plasilova Ivana

¹Klatovy Hospital, Klatovy, Czech Republic; ²Department of Pediatrics, Faculty of Medicine and Faculty Hospital, Hradec Kralove, Czech Republic; ³Department of Pediatrics, Pardubice Hospital, Pardubice, Czech Republic.

ba0007p135

Intravenous bisphosphonate treatment in severe infantile hypercalcemia associated with Williams Syndrome

Guarneri Alissa M Patel Nisha Bowden Sasigarn A

Nationwide Children’s Hospital, Columbus, OH, USA.

ba0007p136

Reversion to pamidronate after switch to zoledronic acid in children with bone disease

Peacock Amanda Bishop Nick Platt Carolyn Greenacre Gemma Crossland C Lee E Arundel Paul

¹Sheffield Children’s Hospital, Sheffield, UK; ²The University of Sheffield, Sheffield, UK.

ba0007p137

How early is early enough - Bisphosphonate treatment in Osteogenesis imperfecta

Hoyer-Kuhn Heike Heistermann Johanna Schonau Eckhard Rehberg Mirko Semler Oliver

University of Cologne, Childrens Hospital, Cologne, Germany.

ba0007p138

Growth hormone therapy in a child with severe short stature due to Miller-McKusick-Malvaux (3M) syndrome-2

Seneviratne Sumudu Silva Deepthi de Cottrell Emily Kuruppu Piumi Silva KSH de Storr Helen

¹Faculty of Medicine, University of Colombo, Colombo, Sri Lanka; ²Faculty of Medicine, University of Kelaniya, Sri Lanka; ³William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University, London, UK.

ba0007p139

Safety and effectiveness of stoss therapy in children

Fiscaletti Melissa Tannous Paul Wood Nicholas Gunasekera Hasantha Zurynski Yvonne Biggins Andrew Kilo Tatjana Hayes Evan Munns Craig

¹The Children’s Hospital at Westmead, Westmead, Australia; ²The University of Sydney Children’s Hospital Westmead Clinical School, Sydney, Australia; ³Macquarie University, North Ryde, Australia; ⁴BIOCeuticals, Alexandria, Australia.

ba0007p140

Hypercalcaemia and osteonecrosis of the jaw in association with denosumab use in the paediatric population

Wall Christie-Lee Pacey Verity Gray Kelly McGee Richard Fiscaletti Melissa Poon Myra Biggin Andrew Munns Craig

¹The Children’s Hospital at Westmead, Westmead, Australia; ²Macquarie University, North Ryde, Australia; ³The University of Sydney Children’s Hospital Westmead Clinical School, Sydney, Australia; ⁴Sainte Justine University Hospital Centre, Montreal, Canada; ⁵University of Montreal, Montreal, Canada.

ba0007p141

Protocol: a randomized trial of zoledronate in children with cerebral palsy

Soerensen TH Granild-Jensen Jakob Bie Vestergaard Esben Thyssen Rackauskaite Gija Soendergaard Charlotte Farholt Stense Moller-Madsen Bjarne Langdahl Bente

¹Child and Youth, Randers Regional Hospital, Randers, Denmark; ²Danish Orthopaedic Research, dpor.dk, Aarhus, Denmark; ³Osteoporosis Clinic, Aarhus University Hospital, Aarhus, Denmark; ⁴Child and Youth, Aarhus University Hospital, Aarhus, Denmark; ⁵Child and Youth, Regional Hospital West, Herning, Denmark; ⁶Department of Pediatrics, Aalborg University Hospital, Aalborg, Denmark.

ba0007p142

Intermittent bi-daily sub-cutaneous teriparatide infusion in children with hypoparathyroidism: a single-centre experience

Flammier Sacha Bertholet-Thomas Aurelia Tanne Corentin Bacchetta Justine

¹Reference Center for Rare Diseases of Calcium and Phosphate, Lyon, France; ²Service de Néphrologie et Rhumatologie Pédiatrique-Hôpital Femme Mère Enfant, Bron, France; ³LYOS INSERM U1033 Pathophysiology, Diagnosis and treatments of Bone Diseases, Lyon, France.

ba0007p143

A multi-criteria decision analysis of the value of burosumab for the treatment of paediatric patients with X-linked hypophosphatemia in Portugal

Alves Ines Francisco Telma Pinto Helena Sousa Sergio Connor Paul Amorim Miguel Ramos Diogo Azevedo Sofia Vandewalle Bjorn

¹Associação Nacional de Displasias Ósseas, Évora, Portugal; ²Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal; ³Centro Hospitalar São João, Porto, Portugal; ⁴Centro Hospitalar Universitário Coimbra, Coimbra, Portugal; ⁵Kyowa-Kirin International, Marlow, UK; ⁶Exigo Consultores, Lisbon, Portugal.

ba0007p144

Nine-month follow-up data on biochemical, clinical, radiological and functional parameters in a clinical cohort of children at Evelina London Children's Hospital with X-linked hypophosphataemia treated with Burosumab

Sandy Jessica L Gilbey-Cross Robyn Santos Rui Sakka Sophia D Cocca Alessandra Morris Mavali Cheung Moira S

Evelina London Children’s Hospital, London, UK.

ba0007p145

Does prior bisphosphonate therapy in children and adolescents with cerebral palsy alter surgical outcomes?

Fiscaletti Melissa Loucos Robert Jamil Kamal Abdul Biggins Andrew Munns Craig Pacey Verity

¹Sainte Justine University Hospital Centre, Montreal, Canada; ²University of Montreal, Montreal, Canada; ³The University of Sydney Children’s Hospital Westmead Clinical School, Sydney, Australia; ⁴The Children’s Hospital at Westmead, Westmead, Australia; ⁵Macquarie University, North Ryde, Australia; ⁶Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

ba0007p146

Changes in DXA Z-scores during bisphosphonate (BP) therapy in patients with osteogenesis imperfecta (OI) at a tertiary care hospital in South Africa

Siralarala Akhona Pettifor John Morley Thandrayen Kebashni

C.H Baragwanath Academic Hospital, Department of Paediatrics, Faculty of Health Sciences, University of the Witwatersrand., Johannesburg, South Africa.

ba0007p147

Management of foramen magnum stenosis in patients with achondroplasia: relative merit of clinical and radiological indications for foramen magnum decompression

Almeida Timoteo Singleton William Monsell Fergal Smithson Sarah Edwards Richard Burren Christine

¹Department of Paediatric Neurosurgery, Bristol Royal Hospital for Children, University Hospitals Bristol NHS Foundation Trust, Bristol, UK; ²Department of Paediatric Orthopaedics, Bristol Royal Hospital for Children, University Hospitals Bristol NHS Foundation Trust, Bristol, UK; ³Department of Clinical Genetics, St Michaels Hospital, University Hospitals Bristol NHS Foundation Trust, Bristol, UK; ⁴Department of Paediatric Endocrinology, Bristol Royal Hospital for Children, University Hospitals Bristol NHS Foundation Trust, Bristol, UK.

ba0007p148

Bone mineral changes in 43 children with osteogenesis imperfecta treated by pamidronate

Kostik Mikhail Idrisova Rena Buklaev Dmitry Bergaliev Arthur Isupova Eugenia Chikova Irina Kalashnikova Olga

¹Saint-Petersburg State Pediatric Medical University, Saint-Petersburg, Saint-Petersburg, Russian Federation; ²City Children’s Hospital #1, Saint-Petersburg, Russian Federation; ³The Turner Scientific Research Institute For Children’s Orthopedics, Saint-Petersburg, Russian Federation.

ba0007p149

Osteogenesis imperfecta: skeletal outcomes after bisphosphonates discontinuation at final height

Robinson Marie-Eve Trejo Pamela Palomo Telma Glorieux Francis H Rauch Frank

Shriners Hospital for Children - Canada, McGill University, Montreal, Canada.

ba0007p150

The safety and efficacy of denosumab versus zoledronic acid in the treatment of pediatric osteoporosis: a randomized controlled pilot trial

Robinson Marie-Eve Ma Jinhui Khan Nasrin Khatchadourian Karine Page Marika Konji Victor Ann Matzinger Mary Shenouda Nazih Jaremko Jacob L Zuijdwijk Caroline Jackowski Stefan Saleh David MacLeay Lynn Siminoski Kerry Ward Leanne M

¹Shriners Hospital for Children - Canada, McGill University, Montreal, Canada; ²Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada; ³Children’s Hospital of Eastern Ontario Research Institute, Ottawa, Canada; ⁴Department of Pediatrics, University of Ottawa, Ottawa, Canada; ⁵Department of Medical Imaging, Children’s Hospital of Eastern Ontario and University of Ottawa, Ottawa, Canada; ⁶Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, Canada; ⁷Department of Pediatrics, Queen’s University, Kingston, Canada; ⁸Department of Radiology and Diagnostic Imaging and Department of Medicine, University of Alberta, Edmonton, Canada.

ba0007p151

An evaluation of the rebound phenomenon during denosumab therapy in children with low turnover osteoporosis

Robinson Marie-Eve Ma Jinhui Khan Nasrin Khatchadourian Karine Page Marika Konji Victor Ann Matzinger Mary Shenouda Nazih Jaremko Jacob L Zuijdwijk Caroline Jackowski Stefan Saleh David MacLeay Lynn Siminoski Kerry Ward Leanne M

¹Shriners Hospital for Children - Canada, McGill University, Montreal, Canada; ²Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada; ³Children’s Hospital of Eastern Ontario Research Institute, Ottawa, Canada; ⁴Department of Pediatrics, University of Ottawa, Ottawa, Canada; ⁵Department of Medical Imaging, Children’s Hospital of Eastern Ontario and University of Ottawa, Ottawa, Canada; ⁶Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, Canada; ⁷Department of Pediatrics, Queen’s University, Kingston, Canada; ⁸Department of Radiology and Diagnostic Imaging and Department of Medicine, University of Alberta, Edmonton, Canada.

ba0007p152

Long-term growth hormone treatment alters glucose metabolism in achondroplasia

Harada Daisuke Kashiwagi Hiroko Ueyama Kaoru Oriyama Kyoko Hanioka Yuki Sakamoto Natsuko Kondo Masafumi Izui Kawai Nagamatsu Yuiko Yamada Hiroyuki Seino Yoshiki Namba Noriyuki

Osaka Hospital, Japan Community Healthcare Organization (JCHO), Osaka, Japan.

ba0007p153

Self-reported sedentary time is negatively associated with microarchitecture of the tibia

Moon Rebecca Gillespie Tom Quiney Naomi Cooper Cyrus Harvey Nicholas Davies Justin

¹MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; ²Paediatric Endocrinology, University Hospital Southampton NHS Foundation Trust, Southampton, UK.

ba0007p154

Gender specific paediatric reference data for muscle function parameters assessed using jumping mechanography

Palande Sonal Ekbote Veena Chiplonkar Shashi Padidela Raja Mughal Zulf Vispute Smruti Rawer Rainer Khadilkar Anuradha Khadilkar Vaman

¹Hirabai Cowasji Jehangir Medical Research Institute, Pune, India; ²Department of Paediatric Endocrinology, Royal Manchester Children’s Hospital, Manchester University, Manchester, UK; ³Novotec Medical GmbH, Pforzheim, Germany.

ba0007p155

Patients with nephropatic cystinosis display lower cortical thickness and grip strength

Bechtold-Dalla Pozza Susanne Froschauer Sonja Harms Erik Herzig Nadine Holla Heike Knerr C Koeppel Christian Landthaler I Prilinger C Steidle G Vill Katharina Treikauskas Ulrike Hohenfellner Katharina

¹Interdisciplinary Cystinosis Clinics, iSPZ, Dr. von Haunersche Kinderklinik, LMU Munich, Munich, Germany; ²Cystinose Stiftung, Munich, Germany.

ba0007p156

Gonadotrophin releasing hormone analogues utilised in late and post-pubertal adolescents causes a reduction in bone density in transgender teenagers attending a national gender dysphoria clinic

Tseretopoulou Xanthippi Amin Nadia Sabah Alvi Mushtaq Talat

¹Leeds Teaching Hospitals NHS Trust, Leeds, UK; ²University of Leeds, Department: Leeds Institute of Cancer and Pathology, Leeds, UK.

ba0007p157

Association of grip strength and body composition in Indian boys and girls

Palande Sonal Ekbote Veena Chiplonkar Shashi Vispute Smruti Khadilkar Vaman Khadilkar Anuradha

Hirabai Cowasji Jehangir Medical Research Institute, Pune, India.

ba0007p158

Determinants of muscle function in 6 to 11 year old rural Indian children

Palande Sonal Ekbote Veena Chauthmal Sujata Vispute Smruti Chiplonkar Shashi Khadilkar Vaman Khadilkar Anuradha

Hirabai Cowasji Jehangir Medical Research Institute, Pune, India.

ba0007p159

Assessment of muscle mass and function in Indian children with type 1 diabetes

Palande Sonal Lohiya Nikhil Ekbote Veena Khadilkar Anuradha Khadilkar Vaman Chiplonkar Shashi

Hirabai Cowasji Jehangir Medical Research Institute, Pune, India.

ba0007p160

Endocrinological complications in Czech paediatric patients with Duchenne muscular dystrophy

Sediva Marie Soucek Ondrej Haberlova Jana

¹Department of Paediatric Neurology, 2nd Faculty of Medicine of Charles University in Prague and University Hospital Motol, Prague, Czech Republic; ²Department of Pediatrics, 2nd Faculty of Medicine of Charles University in Prague and University Hospital Motol, Prague, Czech Republic.

ba0007p161

Bone monitoring and morbidity in adults with duchenne muscular dystrophy: Challenges in implementation of standards of care

Harris Anne-Marie Di Marco Marina Raeside David Davidson Scott Gallacher Stephen Farrugia Maria Wong Sze Choong

¹Developmental Endocrinology Research Group, Royal Hospital for Children, Glasgow, UK; ²Scottish Muscle Network, Queen Elizabeth University Hospital, Glasgow, UK; ³Department of Respiratory, Queen Elizabeth University Hospital, Glasgow, UK; ⁴Department of Diabetes and Endocrinology, Queen Elizabeth University Hospital, Glasgow, UK; ⁵Department of Neurology, Queen Elizabeth University Hospital, Glasgow, UK.

ba0007p162

Prenatal oligohydramnios is associated with hip shape in adolescent males

Tobias Jon Frysz Monika Lawlor Debbie Aspden Richard Gregory Jennifer Ireland Alex

¹Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK; ²MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK; ³Population Health Science, Bristol Medical School, Bristol University, Bristol, UK; ⁴Bristol NIHR Biomedical Research Centre, Bristol, UK; ⁵Aberdeen Centre for Arthritis and Musculoskeletal Health, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK; ⁶Musculoskeletal Science and Sports Medicine Research Centre, Manchester Metropolitan University, Manchester, UK.

ba0007p163

Musculoskeletal deficits persist up to two years despite anti-TNF-alpha antibody therapy in children with Crohn's disease: Results of a prospective, observational inception cohort study

Jackowski Stefan A Ma Jinhui Benchimol Eric I Rauch Frank Leonard Mary B Zemel Babette S Matzinger Mary Ann Shenouda Nazih Lentle Brian Jaremko Jacob L Khatchadourian Karine Robinson Marie-Eve Konji Victor N Siminoski Kerry Mack David Ward Leanne M

¹Children’s Hospital of Eastern Ontario Research Institute, University of Ottawa, Ottawa, Canada; ²Department of Health Research Methods, Evidence, and Impact McMaster University, Hamilton, Canada; ³Department of Pediatrics, CHEO IBD Centre, University of Ottawa, Ottawa, Canada; ⁴Department of Pediatrics, University of Ottawa, Ottawa, Canada; ⁵Department of Pediatrics, McGill University, Montreal, Canada; ⁶Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California, USA; ⁷Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA; ⁸Department of Medical Imaging, University of Ottawa, Ottawa, Canada; ⁹Department of Radiology, University of British Columbia, Vancouver, Canada; ¹⁰Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, Canada; ¹¹Department of Medicine, University of Alberta, Edmonton, Canada.

ba0007p164

Fibroblast growth factor-21 (FGF-21) - marker of mineral bone disorder

Ticha Lubica Kovalčikova Alexandra Gaal Čagalova Alžbeta Šebekova Katarina Podracka Ludmila

¹Nationale Institute of Children’s Diseases of Faculty of Medicine, Comenius University, Bratislava, Slovakia; ²Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia.

ba0007p165

The ketogenic diet and bone density: a retrospective longitudinal cohort study

Draaisma Jos Hampsink Brieke Willemsen Michel Linders Miel van Houdt Nicole

Radboudumc Amalia Children’s Hospital, Nijmegen, Netherlands.

ba0007p166

Children's multivitamins do not contain sufficient vitamin D

Moon Rebecca Curtis Elizabeth Cooper Cyrus Davies Justin Harvey Nicholas

¹MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; ²Paediatric Endocrinology, University Hospital Southampton NHS Foundation Trust, Southampton, UK.

ba0007p167

Abstract unavailable

ba0007p168

Rescue diet restores bone matrix mineralization in mice with a non-functioning vitamin D receptor

Misof Barbara Blouin Stephane Hartmann Markus Hofstaetter Jochen Klaushofer Klaus Zwerina Jochen Roschger Paul Erben Reinhold

¹Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital, Wien, Austria; ²Orthopaedic Hospital Vienna Speising, Wien, Austria; ³Department of Biomedical Sciences, University of Veterinary Medicine, Wien, Austria.

ba0007p169

Serum 25-hydroxyvitamin D requirements to prevent rickets in Nigerian children on a calcium-deprived diet

Thacher Tom Sempos Christopher Durazo-Arvizu Ramon Munns Craig Fischer Philip Pettifor John

¹Mayo Clinic, Rochester, USA; ²Vitamin D Standardization Program LLC, Havre de Grace, USA; ³Loyola University Chicago, Chicago, USA; ⁴The Children’s Hospital at Westmead, Sydney, Australia; ⁵University of the Witwatersrand, Johannesburg, South Africa.

ba0007p170

Seasonal variations in vitamin D status in children with haematological malignancies in Sweden

Jackmann Natalja Makitie Outi Harila-Saari Arja Gustafsson Jan Dernroth Dzeneta Nezirevic Frisk Per

¹Department of Women’s and Children’s Health, University Children’s Hospital, Uppsala, Sweden; ²Department of Molecular Medicine and Surgery, Karolinska Institute, and Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden; ³Department of Clinical Chemistry and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

ba0007p171

Cow's milk allergic infants on amino acid-based medical nutrition formula maintain adequate serum concentrations of phosphorus, calcium and magnesium despite the use of acid-suppressive medication

Harvey Bryan M Eussen Simone RBM Helvoort Ardy van Harthoorn Lucien F

¹Children’s Investigational Research Program, LLC (ChiRP), Bentonville, USA; ²Danone Nutricia Research, Nutricia Advanced Medical Nutrition, Utrecht, The Netherlands; ³Maastricht University, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht, The Netherlands.

ba0007p172

Motor and nutritional aspects of individuals with osteogenesis imperfecta assisted in Brazilian midwest region

Castro Luiz Claudio de Coelho Giovana Luiz Livia David Ana Cristina de

Universidade de Brasília, Brasilia, Brazil.

ba0007p173

Supplementation of children with type 1 diabetes with milk or pharmacological calcium for improving bone health - a randomized controlled trial

Palande Sonal Lohiya Nikhil Mughal Zulf Padidela Raja Chiplonkar Shashi Ekbote Veena Khadilkar Anuradha Khadilkar Vaman

¹Hirabai Cowasji Jehangir Medical Research Institute, Pune, India; ²Department of Paediatric Endocrinology, Royal Manchester Children’s Hospital Manchester University NHS Foundation Trust, Manchester, UK.

ba0007p174

Dietary behaviours and compromised nutritional intakes in children with Osteogenesis Imperfecta

Mills Lisa Clark Robert Birch Laura Burren Christine P

¹Department of Paediatric Therapies, Bristol Royal Hospital for Children, University Hospital Bristol NHS Foundation Trust, Bristol, UK; ²Highly Specialised Complex Childhood Osteogenesis Imperfecta Service, Bristol Royal Hospital for Children, University Hospitals Bristol NHS Foundation Trust, Bristol, UK; ³Bristol Medical School, Department of Translational Health Sciences, University of Bristol, Bristol, UK; ⁴Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust, Bristol, UK; ⁵Department of Paediatric Endocrinology and Diabetes, Bristol Royal Hospital for Children, University Hospitals Bristol NHS Foundation Trust, Bristol, UK.

ba0007p175

Prevalence of vitamin D deficiency in newly diagnosed children with cancer

Kecskemethy Heidi Su Annelise Bachrach Steven Fullmer Michell

Nemours/A.I. duPont Hospital for Children, Wilmington, USA.

ba0007p176

Feasibility of a 13-week targeted exercise intervention on tibial bone mineral density in adolescents with Developmental Coordination Disorder

Tan Jocelyn Siafarikas Aris Hands Beth McIntyre Fleur Hart Nicolas Rantalainen Timo Chivers Paola

¹The University of Notre Dame Australia/Institute for Health Research, Fremantle, Australia; ²Perth Children’s Hospital, Nedlands, Australia; ³Edith Cowan University, Joondalup, Australia; ⁴University of Jyvaskyla, Jyvaskyla, Finland.

ba0007p177

The role of hydrotherapy in the management of children with severe Osteogenesis Imperfecta

Hupin Emilie Edwards Karen DeVile Catherine

Great Ormond Street Hospital, London, UK.

ba0007p178

Clinical and radiological characteristics of children's forearm deformations with hereditary multiple exostosis (Clinical observation)

Belousova Ekaterina

The Turner Scientific and Research Institute for Children’s Orthopedics, Saint-petersburg, Russian Federation.

ba0007p179

A retrospective review of modern spine surgery in the skeletal dysplasia population

Lovecchio Francis Shafi Karim Steinhaus Michael Samuel Andre Farmer James Sava Maria Carter Erin Raggio Cathleen

Hospital for Special Surgery, New York, NY, USA.

ba0007p180

Walking quality of children with healed Perthes disease

Jamil Kamal Fuller Joel Li Jamie Bucknell Michael McKay Marney Baldwin Jennifer Burns Joshua Munns Craig Pacey Verity

¹The Children’s Hospital at Westmead, Westmead, Australia; ²The University of Sydney Children’s Hospital at Westmead Clinical School, Sydney, Australia; ³Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia; ⁴Macquarie University, North Ryde, Australia.

ba0007p181

Handgrip strength as functionality and independence indicative in Osteogenesis Imperfecta

Claudio de Castro Luiz Luiz Livia Coelho Giovana Cristina de David Ana

Universidade de Brasília, Brasília, Brazil.

ba0007p182

Functional outcomes of an adult with Osteogenesis Imperfecta after rehabilitation post-bilateral Girdlestone procedure: a case report

Supnet Isabella Abiera Joycie Eulah Alcausin Maria Melanie Liberty Javier Juanito Sumpaico Carlo Emmanuel

Philippine General Hospital, Manila, Philippines.

ba0007p183

Material based on bioactive glass to replace bone defects in children after removal of tumors

Protsenko Volodymyr Abudayeh Audai

¹Institute of Traumatology and Orthopedics of NAMS of Ukraine, Kiev, Ukraine; ²Bogomolets National Medical University, Ministry of Ukraine, Kiev, Ukraine.

ba0007p184

High impact exercise to improve musculoskeletal outcomes in Crohn's disease: a feasibility questionnaire

Steell Lewis Gaya Daniel R Macdonald Jonathan Russell Richard K Seenan John Paul Wong Sze Choong Gray Stuart

¹Institute of Cardiovascular and Medical Science, University of Glasgow, Glasgow, UK; ²Developmental Endocrinology Research Group, University of Glasgow, Glasgow, UK; ³Department of Gastroenterology, NHS Greater Glasgow & Clyde, Glasgow, UK; ⁴Department of Paediatric Gastroenterology, The Royal Hospital for Children, Glasgow, UK.

ba0007p185

Severe osteoporosis with life threatening vertebral fractures in a 15-years-old boy with juvenile idiopathic arthritis: a successful spinal cord decompression and posterior spinal fusion Th2-Th12

Abramowicz Pawel Grabala Pawel Guszczyn Tomasz Stawicki Maciej Konstantynowicz Jerzy

¹Department of Pediatric Rheumatology, Immunology, and Metabolic Bone Diseases, Medical University of Bialystok, Bialystok, Poland; ²Department of Pediatric Orthopedics and Traumatology, Medical University of Bialystok, Bialystok, Poland.

ba0007p186

Increased prevalence of overweight and obesity and its clinical predictors in children affected by X-linked hypophosphatemia

Zhukouskaya Volha V Rothenbuhler Anya Colao Annamaria Di Somma Carolina Kamenicky Peter Trabado Severine Prie Dominique Audrain Christelle Barosi Anna Kyheng Christele Lambert Anne-Sophie Linglart Agnes

¹APHP, Reference Center for Rare Disorders of the Calcium and Phosphate Metabolism, Filiere OSCAR and Platform of expertise for rare diseases Paris-Sud, Bicêtre Paris-Sud Hospital, Le Kremlin-Bicêtre, France; ²Department of Clinical Medicine and Surgery, Division of Endocrinology, University of Naples Federico II, Naples, Italy; ³APHP, Department of Endocrinology and Diabetology for children, Bicêtre Paris Sud Hospital, Le Kremlin-Bicêtre, France; ⁴IRCCS SDN, Naples, Italy; ⁵APHP, Department of Endocrinology and Reproductive Diseases, Bicêtre Paris Sud Hospital, Le Kremlin-Bicêtre, France; ⁶APHP, Department of Molecular Genetics, Pharmacogenetics and Hormonology, Bicêtre Paris-Sud Hospital, Le Kremlin-Bicêtre, France; ⁷Université Paris V, Faculté de Médecine, Paris, France; ⁸Hôpital Necker Enfants Malades APHP, INSERM U1151, Paris, France; ⁹APHP, Department of Adolescent Medicine, Bicêtre Paris Sud Hospital, Le Kremlin-Bicêtre, France; ¹⁰Paris Sud – Paris Saclay University, Faculté de Médecine, Le Kremlin-Bicêtre, France.

ba0007p187

Impact of type 1 diabetes mellitus on skeletal integrity and strength in adolescents aged 12 to 16 years; as assessed by High Resolution peripheral Quantitative Computed Tomography (HRpQCT)

Devaraja Janani Dimitri Paul Paggiosi Margaret Clark Carolyn Jacques Richard Bishop Nick

¹Children Hospital NHS Trust, Sheffield, UK; ²University of Sheffield, Sheffield, UK.

ba0007p188

Cleidocranial dysplasia: a patient with severe dental phenotype

Doulgeraki Artemis Gatzogianni Margarita Gyftodimou Yolanda Polyzois Georgios Athanasopoulou Helen Agouropoulos Andreas

¹Department of Bone and Mineral Metabolism, Institute of Child Health, Athens, Greece; ²Department of Paediatric Dentistry, Dental School, National and Kapodistrian University of Athens, Athens, Greece; ³Department of Genetics, Institute of Child Health, Athens, Greece.

ba0007p189

Cone-shaped epiphyses involving the knees: report of a case and differential diagnosis

Doulgeraki Artemis Lykopoulou Lilia Georgiadou Elissavet Stelianidi Athanasia Dermentzoglou Vasiliki Anastasopoulos John Kanaka-Gantenbein Christina

¹Department of Bone and Mineral Metabolis, Institute of Child Health, Athens, Greece; ²1st Department of Paediatrics, Medical School, National and Kapodistrian University of Athens, ‘Agia Sophia’ Children’s Hospital, Athens, Greece; ³Department of Radiology, ‘Agia Sophia’ Children’s Hospital, Athens, Greece; ⁴Department of Paediatric Orthopaedics, ‘Agia Sophia’ Children’s Hospital, Athens, Greece.

ba0007p190

Supporting the emotional well-being of children living with osteogenesis imperfecta; an upstream health promotion initiative

Seasman Ali

Sheffield Children’s NHS Foundation Trust, Sheffield, UK.

ba0007p191

Developing a high chair to meet the needs of infants with Achondroplasia; a collaboration between Evelina London Children's Hospital and Brunel University

Massey Jill Phillips Kathryn Lawrence Jack Davies Angharad Harris Laura Cocca Alessandra Spinelli Gabriella Garaj Vanja Irving Melita Cheung Moira

¹Guys and St Thomas’ NHS Foundation Trust, London, UK; ²Brunel University, Uxbridge, Middlesex, UK.

ba0007p192

Double trouble: A case of trisomy 21 and achondroplasia

Todd Stacey Mason Avril McDevitt Helen

Royal Hospital for Children, Glasgow, UK.

ba0007p193

Skeletal dysplasia in Saul Wilson syndrome

Ljungberg Merete Buciek Hove Hanne

Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

ba0007p194

Growth velocity measured by biomarker, COLX, in Achondroplasia

Hove Hanne

Center for Rare Diseases, Rigshospitalet, Copenhagen, Denmark.

ba0007p195

Sleep related problems in children with osteogenesis imperfecta

Murphy Kieran Hill Claire Barker Nicki Kingshott Ruth

Sheffield Children’s NHS Foundation Trust, Sheffield, UK.

ba0007p196

A playful type of intervention for infants with osteogenesis imperfecta

Jones Rebecca Ford Davina Marr Caroline Seasman Alison Pickett Clare Team Metabolic Bone

Sheffield Children’s Hospital, Sheffield, UK.

ba0007p197

The multidisciplinary team (MDT) approach: What does it look like and why does it matter? An illustration of a true MDT approach to provide holistic care for a child with severe and complex osteogenesis imperfecta

Jones Rebecca Seasman Alison Marr Caroline Bone Team Metabolic

Sheffield Children’s Hospital, Sheffield, UK.

ba0007p198

Diversity of outcomes in randomised trials of interventions for children with osteogenesis imperfecta

McGee Richard Wall Christie-Lee Biggin Andrew Pacey Verity Poon Myra Munns Craig

¹The Children’s Hospital at Westmead, Westmead, Australia; ²The University of Sydney Children’s Hospital Westmead Clinical School, Sydney, Australia; ³Macquarie University, North Ryde, Australia.

ba0007p199

Whole body vibration training for children and adolescents with congenital myopathy

Hutchence Meghan Pacey Verity North Kathryn Clarke Nigel Rose Kristy Biggin Andrew Briody Julie Munns Craig

¹Macquarie University, North Ryde, Australia; ²The Children’s Hospital at Westmead, Westmead, Australia; ³The University of Sydney Children’s Hospital at Westmead Clinical School, Sydney, Australia; ⁴Murdoch Children’s Research Institute, Melbourne, Australia.

ba0007p200

Juvenile dermatomyositis (JDM) and hypoparathyroidism (HP) in an adolescent girl

Miller Jennifer Zimmerman Donald

Ann & Robert H Lurie Children’s Hospital of Chicago, Northwestern University, Feinberg School of Medicine, Chicago, USA.

ba0007p201

Vibration therapy improves mobility and has no detrimental impact on bone health in adolescents with mild cerebral palsy independent of daily protocol duration (9 minutes/day vs. 15 minutes/day)

Gusso Silmara Mahadevan Renuka Derraik Jose Cutfield Wayne Hofman Paul

¹Liggins Institute, University of Auckland, Auckland, New Zealand; ²Department of Exercise Sciences, University of Auckland, Auckland, New Zealand; ³A Better Start- National Science Challenge, University of Auckland, Auckland, New Zealand; ⁴Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden.

ba0007p202

Side-alternating vibration training improves mobility and has no detrimental impact on bone health in young children with mild-moderate cerebral palsy

Gusso Silmara Mahadevan Renuka Cutfield Wayne Hofman Paul

¹Liggins Institute, University of Auckland, Auckland, New Zealand; ²Department of Exercise Sciences, University of Auckland, Auckland, New Zealand.

ba0007p203

A qualitative analysis of the burden-of-illness associated with X-linked hypophosphataemia (XLH) in children and adolescents

Ferizovic Nermina Mak Catherine Marshall Jade Shaw Nick Mughal Zulf

¹MAP BioPharma, Cambridge, UK; ²Birmingham Children’s Hospital and University of Birmingham, Birmingham, UK; ³Royal Manchester Children’s Hospital, Manchester, UK.

ba0007p204

Bone mineral density in surgical hemivertebrae treatment in a prematurely born child − a case study

Vukliš Dragana Krasnik Rastislava Mikov Aleksandra Demeši Drljan Čila Zvekić Svorcan Jelena Lačokova Krasnikova Jarmila

¹Institute of Child and Youth Health Care of Vojvodina, Novi Sad, Serbia; ²University of Novi Sad, Faculty of Medicine, Novi Sad, Serbia; ³Special Hospital for Rheumatic Diseases, Novi Sad, Serbia; ⁴Health Center Bač, Bač, Serbia.

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Robot-assisted exercises in children with cerebral palsy - a case study

Mikov Aleksandra Vukliš Dragana Borovac Branislav Gnjatović Milan Tasevski Jovica Krasnik Rastislava

¹Institute of Child and Youth Health Care of Vojvodina, Novi Sad, Serbia; ²University of Novi Sad, Faculty of Medicine, Novi Sad, Serbia; ³University of Novi Sad, Faculty of Technical Sciences, Novi Sad, Serbia.

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Group exercises aimed at poor body posture correction assisted by humanoid robot - A case study

Mikov Aleksandra Vukliš Dragana Borovac Branislav Gnjatović Milan Tasevski Jovica Krasnik Rastislava

¹Institute of Child and Youth Health Care of Vojvodina, Novi Sad, Serbia; ²University of Novi Sad, Faculty of Medicine, Novi Sad, Serbia; ³University of Novi Sad, Faculty of Technical Sciences, Novi Sad, Serbia.

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Motor developmental outcomes in 2 babies with very severe osteogenesis imperfecta (type II)

Sweeney Claire O'Sullivan Lizzie Sahota Jaskiran Saraff Vrinda Shaw Nick

Birmingham Women’s and Children’s NHS Foundation Trust, Birmingham, UK.

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Persistently low trabecular bone mineral density and normal bone strength at the radius over 3 years after simultaneous pancreas kidney transplantation

Soucek Ondrej Sumnik Zdenek Kratochvilova Simona Brunova Jana

¹Charles University and Motol University Hospital, Praha 5, Czech Republic; ²Institute for Clinical and Experimental Medicine, Praha 4, Czech Republic.

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Premature physeal closure following 13 -cis - retinoic acid administration in neuroblastoma

Vasanwala Rashida Farhad

KK Women’s & Chidren’s Hospital, Singapore, Singapore.

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Value of osteogenesis imperfecta clinical nurse specialists to families and consultants across five UK centres

Heathfield Mark Tucker Ian Sahota Jaskiran Rayner Lauren Greenacre Gemma

¹Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK; ²Bristol Children’s Hospital, Bristol, UK; ³Birmingham Women’s and Children’s Hospital, Birmingham, UK; ⁴Royal Manchester Children’s Hospital, Manchester, UK; ⁵Sheffield Children’s, Sheffield, UK; ⁶Paediatric Osteogenesis Imperfecta National Team (POINT), UK.

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Genetic loss of heparanase does not inhibit osteochondromas in Ext1 and Ext2 double heterozygous hereditary multiple osteochondroma mouse model

Nannuru Kalyan Jimenez Johanna Brydges Susannah Murphy Andrew Economides Aris Hatsell Sarah

Regeneron Pharmaceuticals Inc, Tarrrytown, USA.

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Evaluating a therapy-led school and nursery outreach service for children with Osteogenesis Imperfecta

Bultitude Alex Hupin Emilie DeVile Catherine

Great Ormond Street Hospital, London, UK.

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Assessment of multidisciplinary care of children with osteogenesis imperfecta at The Royal Manchester Children's Hospital

Galloway Paula Nixon Anna Rayner Lauren Panchbhaya Nicola Collins Helen Skae Mars Mughal Zulf Padidela Raja

Royal Manchester Children’s Hospital, Manchester, UK.

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Evaluating the natural history of subcutaneous fat necrosis

Lautatzis Maria-Elena Harrington Jennifer

The Hospital for Sick Children, Toronto, Canada.

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Dual diagnosis of autism and osteogenesis imperfecta: Case examples to illustrate the implications of dual diagnosis for enhanced outcomes for child and family

Jones Rebecca Seasman Alison Marr Caroline Bishop Nicholas Arundel Paul Balasubramanian Meena Team Metabolic Bone

Sheffield Children’s Hospital, Sheffield, UK.

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Abstract unavailable

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Hypercalcemia and parathyroid hormone-related peptide expression in a 3 months old boy with Colon Hemangioendothelioma

Maury Kelly Martin Maria Julia Figueroa Veronica Yogui Analia Gentili Claudia Brunetto Oscar

¹Pedro Elizalde Hospital, Buenos Aires, Argentina; ²Universidad Nacional del sur, Bahia Blanca, Argentina.

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Comparison of cell separation methods, using relative expression of specific growth plate zone markers in a pig model

Javanmardi Alireza Raimann Adalbert Egerbacher Monika Sagmeister Susanne Gleiss Andreas Haeusler Gabriele

¹University Clinic of Pediatrics and Adolescent Medicine, Medical University of Vienna, Währinger Gürtel 18-20 1090, Vienna, Austria; ²Histology and Embryology, Department of Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria; ³Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, Vienna, Austria.

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New perspectives in diagnosis and management of optic neuropathy in fibrous dysplasia: utility of optical coherence tomography and computed tomography measurements

Pan Kristen FitzGibbon Edmond Lee Janice Collins Michael Boyce Alison

¹Skeletal Disorders and Mineral Homeostasis Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA; ²Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA; ³Craniofacial Anomalies and Regeneration Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA.

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Speech and hearing impairment and respiratory complications in a large cohort of patients with Achondroplasia

Cocca Alessandra Irving Melita Gringras Paul Turcu Simona Cheung Moira S

Evelina London Children’s Hospital, Guy’s and St Thomas’ NHS Foundation Trust, London, UK.

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Long-term clinical outcome in chronic recurrent multifocal osteomyelitis (CRMO): the Leiden cohort

Ramautar Ashna IE Hamdy Neveen AT Hissink-Muller Petra CE Cate Rebecca ten Appelman-Dijkstra Natasha M

Leiden University Medical Center, Leiden, The Netherlands.

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A preliminary data of a prospective study on Iranian patients with osteogenesis imperfecta

Hoseinbeyki Moslem Moradifard Shirin Mirkhani Fatemeh Ehsani Parastoo Saghiri Reza Karimipoor Morteza Alaei Mohammareza Ebrahimi-Rad Mina

¹Biochemistry Department, Pasteur Institute of Iran, Tehran, Iran (Islamic Republic of); ²Molecular Biology Department, Pasteur Institute of Iran, Tehran, Iran; ³Molecular Medicine Department, Pasteur Institute of Iran, Tehran, Iran; ⁴Mofid Children Hospital, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran.

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A teenager with recurrent fractures and multiple bone lesions: a diagnostic challenge

Seneviratne Sumudu Nimali Kuruppu Piumi

Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.

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A short girl with severe scoliosis and osteoporosis

Seneviratne Sumudu Nimali Kuruppu Piumi

Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.

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The experience of canakinumab in 2 patients with primary tumor (tumoral) calcinosis

Kostik M Petukhova V Pigareva T Likhacheva T Idrisova R Snegireva L Krasnogorskaya O Suspisin E

¹Saint-Petersburg State Pediatric Medical University, Saint-Petersburg, Russia; ²Smolensk Children’s Clinical Hospital, Saint-Petersburg, Russia; ³City’s Children’s Hospital#1, Saint-Petersburg, Russia; ⁴Center of Oncology named after N.N. Petrova of Ministry of Health of Russia, Saint-Petersburg, Russia.

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Bone Abstracts

9th International Conference on Children's Bone Health

Poster Presentations

BiosciAbstracts