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Bone Abstracts (2019) 7 OC5 | DOI: 10.1530/boneabs.7.OC5

ICCBH2019 Oral Communications (1) (27 abstracts)

Low birthweight is associated with poorer limb muscle mass and grip strength in middle age: findings from the UK Biobank Imaging Enhancement

Elizabeth Curtis 1 , Justin Liu 1 , Kate Ward 1 , Karen Jameson 1 , Zahra Raisi-Estabragh 2 , Jimmy Bell 3 , Steffen Petersen 2 , Cyrus Cooper 1, & Nicholas Harvey 1,

1MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; 2NIHR Advanced Imaging, NIHR Barts Biomedical Research Centre (BRC), Queen Mary University of London, London, UK; 3Research Centre for Optimal Health, Department of Life Sciences, University of Westminster, London, UK; 4NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK; 5NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.

Objectives: Low birthweight has been shown to be associated with poorer musculoskeletal health in later life in a variety of epidemiological studies. We investigated relationships between birthweight, and grip strength or magnetic resonance imaging (MRI) measures of muscle volume in UK Biobank.

Methods: UK Biobank is a large prospective cohort of men and women aged 40–69 years, including a detailed baseline assessment in which birthweight was collected by self-report. A subset underwent MRI examination with the dual-echo Dixon Vibe protocol, from neck to knees. Automated body composition analysis was performed using the AMRA Profiler™ system, to segment and quantify total thigh muscle volume. Grip strength was assessed using a Jamar hydraulic hand dynamometer. Associations between birthweight, and thigh muscle volume or grip strength (expressed as Fisher-Yates z-scores) were investigated using multivariate linear regression analysis. This study was conducted under generic ethics approval (NRES:11/NW/0382).

Results: 3699 participants [1513 men, mean (S.D.) age 61.0 (7.6) years and 2186 women, age 60.1 (7.4) years] were able to recall their birthweight and had their grip strength assessed or underwent MRI body composition analysis. In both men and women, higher birthweight was associated with greater thigh muscle volume (adjusted for age and body mass index (BMI)): men, β (95% CI): 0.229 (0.156, 0.301) S.D./kg, P<0.001; women, β (95% CI): 0.284 (0.221, 0.346) S.D./kg, P<0.001. Higher birthweight was also associated with higher grip strength (adjusted for age and height); men, β (95% CI): 0.123 (0.051, 0.195) S.D./kg, P=0.001; women, β (95% CI): 0.070 (0.007, 0.134) S.D./kg, P=0.031. Apart from the association with grip strength in women, these associations persisted after additional adjustment for current smoking and physical activity.

Conclusion: Birthweight was positively associated with MRI measures of thigh muscle volume and grip strength in a population of middle-aged UK adults. These findings provide novel evidence in support of the developmental programming hypothesis and suggest that interventions to optimise birthweight may help to prevent sarcopenia and reduce the risk of falls in future generations.

(Project 3593)

Disclosure: The authors declared no competing interests.

Volume 7

9th International Conference on Children's Bone Health


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