Searchable abstracts of presentations at key conferences on calcified tissues

ba0006p151 | (1) | ICCBH2017

Characterisation of skeletal developmental in mouse models of Duchenne Muscular Dystrophy

Wood Claire , Wong Sze C , Straub Volker , Ahmed S Faisal , Farquharson Colin

Short stature and osteoporosis are common in DMD. Disease progression can be slowed by glucocorticoids but these are associated with further growth retardation and skeletal fragility. The defect in growth and skeletal development in children with DMD is probably multifactorial and not solely dependent on glucocorticoid exposure. The muscular dystrophy x-linked (mdx) mouse is the most commonly used animal model of DMD. However, its growth phenotype has not been studied...

ba0007p100 | (1) | ICCBH2019

High-resolution MRI assessment of the muscle-fat-bone unit in young adults with childhood onset Crohn's disease

Steell Lewis , Johnston Blair , Ahmed S Faisal , Gaya Daniel R , MacDonald Jonathan , Seenan John Paul , Russell Richard K , Gray Stuart , Wong Jarod

Objective: Childhood onset CrohnÂ’s disease (CO-CD) is associated with musculoskeletal deficits. However, there are limited data regarding muscle-bone outcomes in adults with CO-CD. The current study aimed to comprehensively assess the muscle-fat-bone unit in young adults with CO-CD, using novel methods of MRI, in comparison with healthy controls.Methods: Trabecular microarchitecture and cortical geometry of the distal femur were assessed using 3T mi...