Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp143 | Cancer and bone: basic, translational and clinical | ECTS2013

Bone remodelling in patients with an IgM monoclonal gammopathy (Waldenstrom disease – MGUS)

Chappard Daniel , Bouvard Beatrice , Royer Mathieu , Hoppe Emmanuel , Legrand Erick , Ifrah Norbert , Audran Maurice

An IgM monoclonal gammopathy (MGUS) is often the first sign of a lymphomonocytic B-lymphoma (Waldenström macroglobulinemia-WD). Osteolytic lesions can occur in B cell malignancies (WD, hairy cell leukemia, LLC\..) but are less frequent than in myeloma. In addition, bone remodeling in WD is poorly understood. However, an osteoporosis is often observed in MGUS patients. We studied a series of bone biopsies performed in patients with an IgM gammopathy by histomorphometry, mi...

ba0003pp100 | Cancer and bone: basic, translational and clinical | ECTS2014

Bone quality of metaplastic woven bone of mixed metastases: a FTIRI analysis

Chappard Daniel , Bouvard Beatrice , Masson Charles , Legrand Erick , Audran Maurice , Mabilleau Guillaume , Mieczkowska Aleksandra

Objectives: Most osteolytic tumors are in fact mixed and contain an osteoblastic component associated with the predominant osteolytic areas. This metaplastic woven bone can be evidenced on X-rays as blurred white areas but is always evidenced by histological analysis even in the absence of radiological expression. Metaplastic bone formation reflects the activation of new osteoblasts, the stimulation of the dormant lining cells due to the release of growth factors buried in the...