Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p46 | Bone development/growth and fracture repair | ECTS2016

Bone regeneration using transcript-activated matrices for sustained messenger RNA delivery

Badieyan Zohreh Sadat , Aneja Manish , Berezhanskyy Taras , Rudolph Carsten , Plank Christian

Transcript therapies, using chemically modified messenger RNAs (cmRNAs), are emerging as safer yet promising substitutes for gene and recombinant protein therapies. However, their applications have been limited due to transient translation and relative low stability of cmRNAs, compared to DNAs. Here we showed that vacuum-dried cmRNA-loaded collagen sponges, so called Transcript-Activated Matrices (TAMs), could serve as depots for sustained cmRNA delivery, providing steady stat...