Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p83 | Bone Matrix | ECTS2016

Cortical bone matrix mineralisation is decreased in TRPV4 deficient male, but not in female mice

Roschger Paul , Misof Barbara , Fratzl-Zelman Nadja , Hoenderop Joost , Bindels Rene , van Leeuwen Johannes , Klaushofer Klaus , van der Eerden Bram

Transient receptor potential vanilloid channels (TRPVs) have been implicated in Ca2+ homeostasis and bone metabolism. In particular, TRPV4 deficiency was shown to cause sexual dimorphism in bone metabolism and osteoporotic fracture risk. Cortical bone structure was reported to be altered in male TRPV4 knock-out (TRPV4−/−) mice but not in female TRPV−/− mice compared to sex-matched wildtype (TRPV4+/+) animals.To gain knowledge on t...